Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection
Summa, Vincenzo, Petrocchi, Alessia, Bonelli, Fabio, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Fiore, Fabrizio, Gardelli, Cristina, Gonzalez Paz, Odalys, Hazuda, Daria J, Jones, Philip, Kinzel, Olaf, Laufer, Ralph, Monteagudo, Edith, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Scarpelli, Rita, Stillmock, Kara, Witmer, Marc V, Rowley, Michael
Published in Journal of medicinal chemistry (25.09.2008)
Published in Journal of medicinal chemistry (25.09.2008)
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Journal Article
Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production
Guidi, Alessandra, Lalli, Cristiana, Gimmelli, Roberto, Nizi, Emanuela, Andreini, Matteo, Gennari, Nadia, Saccoccia, Fulvio, Harper, Steven, Bresciani, Alberto, Ruberti, Giovina
Published in PLoS neglected tropical diseases (06.10.2017)
Published in PLoS neglected tropical diseases (06.10.2017)
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Journal Article
Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production
Guidi, Alessandra, Saccoccia, Fulvio, Gennari, Nadia, Gimmelli, Roberto, Nizi, Emanuela, Lalli, Cristiana, Paonessa, Giacomo, Papoff, Giuliana, Bresciani, Alberto, Ruberti, Giovina
Published in Parasites & vectors (27.12.2018)
Published in Parasites & vectors (27.12.2018)
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Journal Article
Synthesis of a hexahydropyrimido[1,2- a]azepine-2-carboxamide derivative useful as an HIV integrase inhibitor
Ferrara, Marco, Crescenzi, Benedetta, Donghi, Monica, Muraglia, Ester, Nizi, Emanuela, Pesci, Silvia, Summa, Vincenzo, Gardelli, Cristina
Published in Tetrahedron letters (19.11.2007)
Published in Tetrahedron letters (19.11.2007)
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Journal Article
Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors
Ponzi, Simona, Bresciani, Alberto, Kaiser, Marcel, Nardi, Valentina, Nizi, Emanuela, Ontoria, Jesus M., Pace, Paola, Paonessa, Giacomo, Summa, Vincenzo, Harper, Steven
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
Published in Bioorganic & medicinal chemistry letters (15.04.2020)
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Journal Article
Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins
Nizi, Emanuela, Sferrazza, Alessio, Fabbrini, Danilo, Nardi, Valentina, Andreini, Matteo, Graziani, Rita, Gennari, Nadia, Bresciani, Alberto, Paonessa, Giacomo, Harper, Steven
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
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Journal Article
Development of Peptidomimetics with a Vinyl Sulfone Warhead as Irreversible Falcipain-2 Inhibitors
Ettari, Roberta, Nizi, Emanuela, Di Francesco, Maria Emilia, Dude, Marie-Adrienne, Pradel, Gabriele, Vičík, Radim, Schirmeister, Tanja, Micale, Nicola, Grasso, Silvana, Zappalà, Maria
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
Improved Selective Class I HDAC and Novel Selective HDAC3 Inhibitors: Beyond Hydroxamic Acids and Benzamides
Bresciani, Alberto, Ontoria, Jesus M, Biancofiore, Ilaria, Cellucci, Antonella, Ciammaichella, Alina, Di Marco, Annalise, Ferrigno, Federica, Francone, Alessandra, Malancona, Savina, Monteagudo, Edith, Nizi, Emanuela, Pace, Paola, Ponzi, Simona, Rossetti, Ilaria, Veneziano, Maria, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (11.04.2019)
Published in ACS medicinal chemistry letters (11.04.2019)
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Journal Article
Novel Peptidomimetics Containing a Vinyl Ester Moiety as Highly Potent and Selective Falcipain-2 Inhibitors
Ettari, Roberta, Micale, Nicola, Schirmeister, Tanja, Gelhaus, Christoph, Leippe, Matthias, Nizi, Emanuela, Di Francesco, Maria Emilia, Grasso, Silvana, Zappalà, Maria
Published in Journal of medicinal chemistry (09.04.2009)
Published in Journal of medicinal chemistry (09.04.2009)
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Journal Article
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
Harper, Steven, McCauley, John A, Rudd, Michael T, Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W, Romano, Joseph J, Bush, Kimberly J, Gilbert, Kevin F, McIntyre, Charles J, Nguyen, Kevin T, Nizi, Emanuela, Carroll, Steven S, Ludmerer, Steven W, Burlein, Christine, DiMuzio, Jillian M, Graham, Donald J, McHale, Carolyn M, Stahlhut, Mark W, Olsen, David B, Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M, Rowley, Michael, Coleman, Paul J, Vacca, Joseph P, Summa, Vincenzo, Liverton, Nigel J
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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Journal Article
Discovery of a Selective Series of Inhibitors of Plasmodium falciparum HDACs
Ontoria, Jesus M, Paonessa, Giacomo, Ponzi, Simona, Ferrigno, Federica, Nizi, Emanuela, Biancofiore, Ilaria, Malancona, Savina, Graziani, Rita, Roberts, David, Willis, Paul, Bresciani, Alberto, Gennari, Nadia, Cecchetti, Ottavia, Monteagudo, Edith, Orsale, Maria V, Veneziano, Maria, Di Marco, Annalise, Cellucci, Antonella, Laufer, Ralph, Altamura, Sergio, Summa, Vincenzo, Harper, Steven
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Journal Article
Discovery and Synthesis of HIV Integrase Inhibitors: Development of Potent and Orally Bioavailable N-Methyl Pyrimidones
Gardelli, Cristina, Nizi, Emanuela, Muraglia, Ester, Crescenzi, Benedetta, Ferrara, Marco, Orvieto, Federica, Pace, Paola, Pescatore, Giovanna, Poma, Marco, Rico Ferreira, Maria del Rosario, Scarpelli, Rita, Homnick, Carl F, Ikemoto, Norihiro, Alfieri, Anna, Verdirame, Maria, Bonelli, Fabio, Gonzalez Paz, Odalys, Taliani, Marina, Monteagudo, Edith, Pesci, Silvia, Laufer, Ralph, Felock, Peter, Stillmock, Kara A, Hazuda, Daria, Rowley, Michael, Summa, Vincenzo
Published in Journal of medicinal chemistry (04.10.2007)
Published in Journal of medicinal chemistry (04.10.2007)
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Journal Article
Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors
Pace, Paola, Di Francesco, M. Emilia, Gardelli, Cristina, Harper, Steven, Muraglia, Ester, Nizi, Emanuela, Orvieto, Federica, Petrocchi, Alessia, Poma, Marco, Rowley, Michael, Scarpelli, Rita, Laufer, Ralph, Gonzalez Paz, Odalys, Monteagudo, Edith, Bonelli, Fabio, Hazuda, Daria, Stillmock, Kara A, Summa, Vincenzo
Published in Journal of medicinal chemistry (03.05.2007)
Published in Journal of medicinal chemistry (03.05.2007)
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Journal Article
Design and Synthesis of Bicyclic Pyrimidinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors
Muraglia, Ester, Kinzel, Olaf, Gardelli, Cristina, Crescenzi, Benedetta, Donghi, Monica, Ferrara, Marco, Nizi, Emanuela, Orvieto, Federica, Pescatore, Giovanna, Laufer, Ralph, Gonzalez-Paz, Odalys, Di Marco, Annalise, Fiore, Fabrizio, Monteagudo, Edith, Fonsi, Massimiliano, Felock, Peter J, Rowley, Michael, Summa, Vincenzo
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain-2 Inhibitors
Ettari, Roberta, Nizi, Emanuela, Di Francesco, Maria Emilia, Micale, Nicola, Grasso, Silvana, Zappalà, Maria, Vičík, Radim, Schirmeister, Tanja
Published in ChemMedChem (14.07.2008)
Published in ChemMedChem (14.07.2008)
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Journal Article
Novel Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease Featuring a 2-Amino-1,3-thiazole as a P4 Carbamate Replacement
Di Francesco, M. Emilia, Dessole, Gabriella, Nizi, Emanuela, Pace, Paola, Koch, Uwe, Fiore, Fabrizio, Pesci, Silvia, Di Muzio, Jillian, Monteagudo, Edith, Rowley, Michael, Summa, Vincenzo
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Journal Article
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase
Pace, Paola, Nizi, Emanuela, Pacini, Barbara, Pesci, Silvia, Matassa, Victor, De Francesco, Raffaele, Altamura, Sergio, Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Journal Article
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: Improving cell based activity by the quaternarization of a chiral center
Nizi, Emanuela, Orsale, Maria Vittoria, Crescenzi, Benedetta, Pescatore, Giovanna, Muraglia, Ester, Alfieri, Anna, Gardelli, Cristina, Spieser, Stéphane A.H., Summa, Vincenzo
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Journal Article
Capped dipeptide α-Ketoacid inhibitors of the HCV NS3 protease
Nizi, Emanuela, Koch, Uwe, Ponzi, Simona, Matassa, Victor G, Gardelli, Cristina
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
Published in Bioorganic & medicinal chemistry letters (18.11.2002)
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Journal Article
Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease
NIZI, Emanuela, KOCH, Uwe, ONTORIA, Jesus M, MARCHETTI, Antonella, NARJES, Frank, MALANCONA, Savina, MATASSA, Victor G, GARDELLI, Cristina
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Journal Article