A reversed sulfonamide series of selective RORc inverse agonists
van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., René, Olivier, Ward, Stuart I., de Leon Boenig, Gladys, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
Published in Bioorganic & medicinal chemistry letters (01.12.2014)
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Mycobacterium tuberculosis Chaperonin 10 Is Secreted in the Macrophage Phagosome: Is Secretion Due to Dissociation and Adoption of a Partially Helical Structure at the Membrane?
Fossati, Gianluca, Izzo, Gaetano, Rizzi, Emanuele, Gancia, Emanuela, Modena, Daniela, Moras, Maria Luisa, Niccolai, Neri, Giannozzi, Elena, Spiga, Ottavia, Bono, Letizia, Marone, Piero, Leone, Eugenio, Mangili, Francesca, Harding, Stephen, Errington, Neil, Walters, Christopher, Henderson, Brian, Roberts, Michael M, Coates, Anthony R M, Casetta, Bruno, Mascagni, Paolo
Published in Journal of Bacteriology (01.07.2003)
Published in Journal of Bacteriology (01.07.2003)
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Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods
Gancia, Emanuela, De Groot, Marcel, Burton, Brenda, Clark, David E.
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
Published in Bioorganic & medicinal chemistry letters (01.06.2017)
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The Rational Design of Selective Benzoxazepin Inhibitors of the α‑Isoform of Phosphoinositide 3‑Kinase Culminating in the Identification of (S)‑2-((2-(1-Isopropyl‑1H‑1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)
Heffron, Timothy P, Heald, Robert A, Ndubaku, Chudi, Wei, BinQing, Augistin, Martin, Do, Steven, Edgar, Kyle, Eigenbrot, Charles, Friedman, Lori, Gancia, Emanuela, Jackson, Philip S, Jones, Graham, Kolesnikov, Aleksander, Lee, Leslie B, Lesnick, John D, Lewis, Cristina, McLean, Neville, Mörtl, Mario, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Staben, Steven T, Steinbacher, Stefan, Tsui, Vickie, Wallin, Jeffrey, Sampath, Deepak, Olivero, Alan G
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)
Chan, Bryan K, Seward, Eileen, Lainchbury, Michael, Brewer, Thomas F, An, Le, Blench, Toby, Cartwright, Matthew W, Chan, Grace Ka Yan, Choo, Edna F, Drummond, Jason, Elliott, Richard L, Gancia, Emanuela, Gazzard, Lewis, Hu, Baihua, Jones, Graham E, Luo, Xifeng, Madin, Andrew, Malhotra, Sushant, Moffat, John G, Pang, Jodie, Salphati, Laurent, Sneeringer, Christopher J, Stivala, Craig E, Wei, Binqing, Wang, Weiru, Wu, Ping, Heffron, Timothy P
Published in ACS medicinal chemistry letters (13.01.2022)
Published in ACS medicinal chemistry letters (13.01.2022)
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Discovery of Novel Allosteric Mitogen-Activated Protein Kinase Kinase (MEK) 1,2 Inhibitors Possessing Bidentate Ser212 Interactions
Heald, Robert A, Jackson, Philip, Savy, Pascal, Jones, Mark, Gancia, Emanuela, Burton, Brenda, Newman, Richard, Boggs, Jason, Chan, Emily, Chan, Jocelyn, Choo, Edna, Merchant, Mark, Rudewicz, Patrick, Ultsch, Mark, Wiesmann, Christian, Yue, Qin, Belvin, Marcia, Price, Steve
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Journal Article
Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids
Tehan, Benjamin G., Lloyd, Edward J., Wong, Margaret G., Pitt, Will R., Montana, John G., Manallack, David T., Gancia, Emanuela
Published in Quantitative structure-activity relationships (01.11.2002)
Published in Quantitative structure-activity relationships (01.11.2002)
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Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1
Gazzard, Lewis, Williams, Karen, Chen, Huifen, Axford, Lorraine, Blackwood, Elizabeth, Burton, Brenda, Chapman, Kerry, Crackett, Peter, Drobnick, Joy, Ellwood, Charles, Epler, Jennifer, Flagella, Michael, Gancia, Emanuela, Gill, Matthew, Goodacre, Simon, Halladay, Jason, Hewitt, Joanne, Hunt, Hazel, Kintz, Samuel, Lyssikatos, Joseph, Macleod, Calum, Major, Sarah, Médard, Guillaume, Narukulla, Raman, Ramiscal, Judi, Schmidt, Stephen, Seward, Eileen, Wiesmann, Christian, Wu, Ping, Yee, Sharon, Yen, Ivana, Malek, Shiva
Published in Journal of medicinal chemistry (25.06.2015)
Published in Journal of medicinal chemistry (25.06.2015)
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8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor
Humphries, Alexander C., Gancia, Emanuela, Gilligan, Myra T., Goodacre, Simon, Hallett, David, Merchant, Kevin J., Thomas, Steve R.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
A reversed sulfonamide series of selective RORc inverse agonists
van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., Rene, Olivier, Ward, Stuart I., Boenig, Gladys de Leon, Deng, Yuzhong, Eidenschenk, Celine, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
Published in Bioorganic & medicinal chemistry letters (15.12.2014)
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Journal Article
8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor
Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article
Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 2: Application to Amines, Anilines and Various Nitrogen Containing Heterocyclic Compounds
Tehan, Benjamin G., Lloyd, Edward J., Wong, Margaret G., Pitt, Will R., Gancia, Emanuela, Manallack, David T.
Published in Quantitative structure-activity relationships (01.11.2002)
Published in Quantitative structure-activity relationships (01.11.2002)
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DIAZACARBAZOLES AND METHODS OF USE
CALUM MACLEOD, HAZEL JOAN DYKE, KAREN WILLIAMS, LYSSIKATOS JOSEPH P, CHEN HUIFEN, SIMON CHARLS GOODACRE, GAZZARD LEWIS J, EMANUELA GANCIA
Year of Publication 16.10.2014
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Year of Publication 16.10.2014
Patent
DIAZACARBAZOLES AND METHODS OF USE
CALUM MACLEOD, HAZEL JOAN DYKE, KAREN WILLIAMS, LYSSIKATOS JOSEPH P, CHEN HUIFEN, SIMON CHARLS GOODACRE, GAZZARD LEWIS J, CHARLES ELLWOOD, SAMUEL S KINTZ, EMANUELA GANCIA
Year of Publication 12.02.2015
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Year of Publication 12.02.2015
Patent
MS-WHIM, new 3D theoretical descriptors derived from molecular surface properties: a comparative 3D QSAR study in a series of steroids
Bravi, G, Gancia, E, Mascagni, P, Pegna, M, Todeschini, R, Zaliani, A
Published in Journal of computer-aided molecular design (01.01.1997)
Published in Journal of computer-aided molecular design (01.01.1997)
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Journal Article
Theoretical hydrogen bonding parameters for drug design
Gancia, Emanuela, Montana, John G., Manallack, David T.
Published in Journal of molecular graphics & modelling (01.01.2001)
Published in Journal of molecular graphics & modelling (01.01.2001)
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Journal Article
8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA sub(A) receptor
Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
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Journal Article