Non-peptidic small molecule inhibitors of XIAP
Park, Cheol-Min, Sun, Chaohong, Olejniczak, Edward T., Wilson, Alan E., Meadows, Robert P., Betz, Stephen F., Elmore, Steven W., Fesik, Stephen W.
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Differentiation of in vitro transcriptional repression and activation profiles of selective glucocorticoid modulators
Elmore, Steven W, Pratt, John K, Coghlan, Michael J, Mao, Yue, Green, Brian E, Anderson, David D, Stashko, Michael A, Lin, Chun W, Falls, Douglas, Nakane, Masaki, Miller, Loan, Tyree, Curtis M, Miner, Jeffrey N, Lane, Ben
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Elmore, Steven W, Coghlan, Michael J, Anderson, David D, Pratt, John K, Green, Brian E, Wang, Alan X, Stashko, Michael A, Lin, Chun W, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Lane, Benjamin C
Published in Journal of medicinal chemistry (06.12.2001)
Published in Journal of medicinal chemistry (06.12.2001)
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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy
Lemasters, John J., Nieminen, Anna-Liisa, Qian, Ting, Trost, Lawrence C., Elmore, Steven P., Nishimura, Yoshiya, Crowe, Ruth A., Cascio, Wayne E., Bradham, Cynthia A., Brenner, David A., Herman, Brian
Published in Biochimica et biophysica acta (10.08.1998)
Published in Biochimica et biophysica acta (10.08.1998)
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Synthesis and Characterization of Non-Steroidal Ligands for the Glucocorticoid Receptor: Selective Quinoline Derivatives with Prednisolone-Equivalent Functional Activity
Coghlan, Michael J, Kym, Philip R, Elmore, Steven W, Wang, Alan X, Luly, Jay R, Wilcox, Denise, Stashko, Michael, Lin, Chun-Wei, Miner, Jeffrey, Tyree, Curtis, Nakane, Masaki, Jacobson, Peer, Lane, Benjamin C
Published in Journal of medicinal chemistry (30.08.2001)
Published in Journal of medicinal chemistry (30.08.2001)
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Design, Synthesis, and Computational Studies of Inhibitors of Bcl-XL
Park, Cheol-Min, Oie, Tetsuro, Petros, Andrew M, Zhang, Haichao, Nimmer, Paul M, Henry, Rodger F, Elmore, Steven W
Published in Journal of the American Chemical Society (20.12.2006)
Published in Journal of the American Chemical Society (20.12.2006)
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Hydrodynamic evaluations in high rate algae pond (HRAP) design
Hadiyanto, H., Elmore, Steven, Van Gerven, Tom, Stankiewicz, Andrzej
Published in Chemical engineering journal (Lausanne, Switzerland : 1996) (01.02.2013)
Published in Chemical engineering journal (Lausanne, Switzerland : 1996) (01.02.2013)
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Visualization of mitochondria in cardiomyocytes
Barzda, Virginijus, Greenhalgh, Catherine, Aus der Au, Jürg, Elmore, Steven, HGM van Beek, Johannes, Squier, Jeff
Published in Optics express (03.10.2005)
Published in Optics express (03.10.2005)
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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis
Petros, Andrew M, Dinges, Jurgen, Augeri, David J, Baumeister, Steven A, Betebenner, David A, Bures, Mark G, Elmore, Steven W, Hajduk, Philip J, Joseph, Mary K, Landis, Shelley K, Nettesheim, David G, Rosenberg, Saul H, Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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The Bcl-2/Bcl-XL/Bcl-w Inhibitor, Navitoclax, Enhances the Activity of Chemotherapeutic Agents In Vitro and In Vivo
Chen, Jun, Jin, Sha, Abraham, Vivek, Huang, Xiaoli, Liu, Bernard, Mitten, Michael J., Nimmer, Paul, Lin, Xiaoyu, Smith, Morey, Shen, Yu, Shoemaker, Alexander R., Tahir, Stephen K., Zhang, Haichao, Ackler, Scott L., Rosenberg, Saul H., Maecker, Heather, Sampath, Deepak, Leverson, Joel D., Tse, Chris, Elmore, Steven W.
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-X-L Inhibitor
Wang, Le, Doherty, George A., Judd, Andrew S., Tao, Zhi-Fu, Hansen, T. Matthew, Frey, Robin R., Song, Xiaohong, Bruncko, Milan, Kunzer, Aaron R., Wang, Xilu, Wendt, Michael D., Flygare, John A., Catron, Nathaniel D., Judge, Russell A., Park, Chang H., Shekhar, Shashank, Phillips, Darren C., Nimmer, Paul, Smith, Morey L., Tahir, Stephen K., Xiao, Yu, Xue, John, Zhang, Haichao, Le, Phuong N., Mitten, Michael J., Boghaert, Erwin R., Gao, Wenqing, Kovar, Peter, Choo, Edna F., Diaz, Dolores, Fairbrother, Wayne J., Elmore, Steven W., Sampath, Deepak, Leverson, Joel D., Souers, Andrew James
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis
Petros, Andrew M., Dinges, Jurgen, Augeri, David J., Baumeister, Steven A., Betebenner, David A., Bures, Mark G., Elmore, Steven W., Hajduk, Philip J., Joseph, Mary K., Landis, Shelley K., Nettesheim, David G., Rosenberg, Saul H., Shen, Wang, Thomas, Sheela, Wang, Xilu, Zanze, Irini, Zhang, Haichao, Fesik, Stephen W.
Published in Journal of medicinal chemistry (26.01.2006)
Published in Journal of medicinal chemistry (26.01.2006)
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Structure−Activity Studies for a Novel Series of Tricyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH)
Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Condon, Stephen, Elmore, Steven W, Kerwin, James F, Sippy, Kevin B, Tietje, Karin, Wendt, Michael D, Hancock, Arthur A, Brune, Michael E, Buckner, Steven A, Drizin, Irene
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Abstract 3770: HEXIM1 as a pharmacodynamic marker for monitoring target engagement of ABBV-075
Huang, Xiaoli, Lin, Xiaoyu, Li, Leiming, Wang, Rongqi, Roberts, Lisa, Hessler, Paul, Uziel, Tamar, Lam, Lloyd, Magoc, Terry, Albert, Daniel H., Elmore, Steven W., Fang, Guowei, Rosenberg, Saul H., McDaniel, Keith, Kati, Warren, Shen, Yu
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 4738: The BET family bromodomain inhibitor ABBV-075 is a promising therapeutic agent for acute myeloid leukemia and myelodysplastic syndrome
Bui, Mai H., Lin, Xiaoyu, Huang, Xiaoli, Li, Leiming, Sarthy, Aparna, Albert, Daniel, Magoc, Terry, Lam, Lloyd, Hessler, Paul, Uziel, Tamar, Elmore, Steven, McDaniel, Keith, Kati, Warren, Shen, Yu
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 4706: ABBV-075 exhibits robust in vitro and in vivo activities against the ABC and GCB subtypes of DLBCL
Lin, Xiaoyu, Huang, Xiaoli, Sarthy, Aparna, Magoc, Terry, Albert, Daniel, Lam, Lloyd, Uziel, Tamar, Lu, Xin, Bui, Mai-Ha, Faivre, Emily, Wilcox, Denise, Elmore, Steven, McDaniel, Keith, Kati, Warren, Shen, Yu
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Venetoclax (ABT-199), a potent and selective BCL-2 inhibitor, is efficacious in NZB/WF1 mouse model of lupus nephritis and reduces human lymphocyte lifespan in vitro (BA4P.127)
Grebe, Kristie, Perper, Stuart, O'Connor, Liz, Schwartz, Annette, Goess, Christian, Hartman, Dawna, Westmoreland, Susan, Graff, Candace, Souers, Andrew, Leverson, Joel, Elmore, Steven, Olson, Lisa, Wang, Lichun
Published in The Journal of immunology (1950) (01.05.2015)
Published in The Journal of immunology (1950) (01.05.2015)
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