4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II
COOPER, Laura C, CARLSON, Emma J, RYCROFT, Wayne, TSAO, Kwei-Lan, SWAIN, Christopher J, CASTRO, Jose L, CHICCHI, Gary G, DINNELL, Kevin, DI SALVO, Jerry, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Marc M, RIDGILL, Mark P
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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N',2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists
ELLIOTT, Jason M, CARTING, Robert W, MURRAY, Fraser, RIGBY, Michael, ROYO, Inmaculada, RUSSELL, Michael G. N, SOHAL, Bindi, KWEI LAN TSAO, WILLIAMS, Brian, CHAMBERS, Mark, CHICCHI, Gary G, HUTSON, Peter H, JONES, A. Brian, MACLEOD, Angus, MARWOOD, Rose, MENESES-LORENTE, Georgina, MEZZOGORI, Elena
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
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Regioselective synthesis of 4-(2-alkyl-5-methyl-2 H-pyrazol-3-yl)-piperidines
Dirat, Olivier, Clipson, Alex, Elliott, Jason M., Garrett, Sasha, Brian Jones, A., Reader, Michael, Shaw, Duncan
Published in Tetrahedron letters (13.03.2006)
Published in Tetrahedron letters (13.03.2006)
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N',2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II
ELLIOTT, Jason M, CARTING, Robert W, MURRAY, Fraser, RIGBY, Michael, ROYO, Inmaculada, RUSSELL, Michael G. N, SHAW, Duncan, SOHAL, Bindi, KWEI LAN TSAO, WILLIAMS, Brian, CHICCHI, Gary G, CRAWFORTH, James, HUTSON, Peter H, JONES, A. Brian, KELLY, Sarah, MARWOOD, Rose, MENESES-LORENTE, Georgina, MEZZOGORI, Elena
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
Published in Bioorganic & medicinal chemistry letters (15.11.2006)
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2-Aryl indole NK1 receptor antagonists : Optimisation of indole substitution
COOPER, Laura C, CHICCHI, Gary G, WATT, Alan P, WILLIAMS, Angela R, SWAIN, Christopher J, DINNELL, Kevin, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Mare M, LOCKER, Karen L, MORRISON, Denise, SHAW, Duncan E, TSAO, Kwei-Lan
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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NK1 antagonists based on seven membered lactam scaffolds
ELLIOTT, Jason M, CARLSON, Emma J, WHEELDON, Alan, CHICCHI, Gary G, DIRAT, Olivier, DOMINGUEZ, Maria, GERHARD, Ute, JELLEY, Richard, JONES, A. Brian, KURTZ, Marc M, TSAO, Kwei Lan
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide
Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)
Published in Journal of medicinal chemistry (21.11.1997)
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2-Aryl indole NK1 receptor antagonists : Optimisation of the 2-aryl ring and the indole nitrogen substituent
DINNELL, Kevin, CHICCHI, Gary G, SWAIN, Christopher J, DHAR, Madhumeeta J, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Marc M, RIDGILL, Mark P, RYCROFT, Wayne, TSAO, Kwei-Lan, WILLIAMS, Angela R
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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Novel lactam NK1 antagonists with anti-emetic activity
HOLLINGWORTH, Gregory J, CARLSON, Emma J, KURTZ, Marc M, RYCROFT, Wayne, TATTERSALL, F. David, TSAO, Kwei-Lan, SWAIN, Christopher J, CASTRO, José L, CHICCHI, Gary G, CLARK, Natalie, COOPER, Laura C, DIRAT, Olivier, DI SALVO, Jerry, ELLIOTT, Jason M, KILBURN, Ruth
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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2-aryl indole NK1 antagonists : Optimisation of the amide substituent
SHAW, Duncan, CHICCHI, Gary G, ELLIOTT, Jason M, KURTZ, Marc, MORRISON, Denise, RIDGILL, Mark P, SZETO, Nicola, WATT, Alan P, WILLIAMS, Angela R, SWAIN, Christopher J
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
Published in Bioorganic & medicinal chemistry letters (03.12.2001)
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4,4-Disubstituted cyclohexylamine NK1 receptor antagonists I
ELLIOTT, Jason M, CASTRO, Jose L, SWAIN, Christopher J, TSAO, Kwei-Lan, LIHU YANG, CHICCHI, Gary G, COOPER, Laura C, DINNELL, Kevin, HOLLINGWORTH, Gregory J, RIDGILL, Mark P, RYCROFT, Wayne, KURTZ, Marc M, SHAW, Duncan E
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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Journal Article
Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current IKs by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide
SELNICK, Harold G., LIVERTON, Nigel J., BALDWIN, John J., BUTCHER, John W., CLAREMON, David A., ELLIOTT, Jason M., FREIDINGER, Roger M., KING, Stella A., LIBBY, Brian E., MCINTYRE, Charles J., PRIBUSH, David A., REMY, David C., SMITH, Garry R., TEBBEN, Andrew J., JURKIEWICZ, Nancy K., LYNCH, Joseph J., SALATA, Joseph J., SANGUINETTI, Michael C., SIEGL, Peter K. S., SLAUGHTER, Donald E., VYAS, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)
Published in Journal of medicinal chemistry (21.11.1997)
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4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)
Elliott, Jason M, Selnick, Harold G, Claremon, David A, Baldwin, John J, Buhrow, Susan A, Butcher, John W, Habecker, Charles N, King, Stella W, Lynch, Joseph J
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Expeditious synthesis of novel NK1 antagonists based on a 1,2,4-trisubstituted cyclohexane
Dirat, O, Elliott, JM, Jelley, RA, Jones, AB, Reader, M
Published in Tetrahedron letters (20.02.2006)
Published in Tetrahedron letters (20.02.2006)
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NK sub(1) antagonists based on seven membered lactam scaffolds
Elliott, Jason M, Carlson, Emma J, Chicchi, Gary G, Dirat, Olivier, Dominguez, Maria, Gerhard, Ute, Jelley, Richard, Jones, ABrian, Kurtz, Marc M, Tsao, Kwei lan, Wheeldon, Alan
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
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NK 1 antagonists based on seven membered lactam scaffolds
Elliott, Jason M., Carlson, Emma J., Chicchi, Gary G., Dirat, Olivier, Dominguez, Maria, Gerhard, Ute, Jelley, Richard, Jones, A. Brian, Kurtz, Marc M., Tsao, Kwei lan, Wheeldon, Alan
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Novel lactam NK sub(1) antagonists with anti-emetic activity
Hollingworth, Gregory J, Carlson, Emma J, Castro, Jose L, Chicchi, Gary G, Clark, Natalie, Cooper, Laura C, Dirat, Olivier, Di Salvo, Jerry, Elliott, Jason M, Kilburn, Ruth, Kurtz, Marc M, Rycroft, Wayne, Tattersall, FDavid, Tsao, Kwei-Lan, Swain, Christopher J
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
Published in Bioorganic & medicinal chemistry letters (01.01.2006)
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