Search Results - "ELLINGBOE JOHN W" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding

Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding

by Gopalsamy, Ariamala, Chopra, Rajiv, Lim, Kitae, Ciszewski, Gregory, Shi, Mengxiao, Curran, Kevin J., Sukits, Steven F., Svenson, Kristine, Bard, Joel, Ellingboe, John W., Agarwal, Atul, Krishnamurthy, Girija, Howe, Anita Y. M., Orlowski, Mark, Feld, Boris, O'Connell, John, Mansour, Tarek S.
Published in Journal of medicinal chemistry (01.06.2006)

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Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 and S 3 substrate binding pockets

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 and S 3 substrate binding pockets

by Cole, Derek C., Stock, Joseph R., Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W., Fan, Kristi Y., Harrison, Boyd L., Hu, Yun, Jacobsen, Steve, Jennings, Lee D., Jin, Guixian, Lohse, Peter A., Malamas, Michael S., Manas, Eric S., Moore, William J., O’Donnell, Mary-Margaret, Olland, Andrea M., Robichaud, Albert J., Svenson, Kristine, Wu, JunJun, Wagner, Eric, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (01.02.2008)

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Discovery of N-1-(6-chloroimidazo[2,1-b][1,3]-thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist

Discovery of N-1-(6-chloroimidazo[2,1-b][1,3]-thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist

by Cole, Derek C., Stock, Joseph R., Lennox, William J., Bernotas, Ronald C., Ellingboe, John W., Boikess, Steve, Coupet, Joseph, Smith, Deborah L., Leung, Louis, Zhang, Guo-Ming, Feng, Xidong, Kelly, Michael F., Galante, Rocco, Huang, Pingzhong, Dawson, Lee A., Marquis, Karen, Rosenzweig-Lipson, Sharon, Beyer, Chad E., Schechter, Lee E.
Published in Journal of medicinal chemistry (15.11.2007)

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Antihyperglycemic activity of novel naphthalenylmethyl-3H-1,2,3,5-oxathiadiazole 2-oxides

Antihyperglycemic activity of novel naphthalenylmethyl-3H-1,2,3,5-oxathiadiazole 2-oxides

by Ellingboe, John W, Lombardo, Louis J, Alessi, Thomas R, Nguyen, Thomas T, Guzzo, Frieda, Guinosso, Charles J, Bullington, James, Browne, Eric N. C, Bagli, Jehan F
Published in Journal of medicinal chemistry (01.08.1993)

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Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 ′ substrate binding pocket

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S 1 ′ substrate binding pocket

by Jennings, Lee D., Cole, Derek C., Stock, Joseph R., Sukhdeo, Mohani N., Ellingboe, John W., Cowling, Rebecca, Jin, Guixian, Manas, Eric S., Fan, Kristi Y., Malamas, Michael S., Harrison, Boyd L., Jacobsen, Steve, Chopra, Rajiv, Lohse, Peter A., Moore, William J., O’Donnell, Mary-Margaret, Hu, Yun, Robichaud, Albert J., Turner, M. James, Wagner, Erik, Bard, Jonathan
Published in Bioorganic & medicinal chemistry letters (15.01.2008)

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Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H 3 receptor antagonists

Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H 3 receptor antagonists

by Cole, Derek C., Gross, Jonathan L., Comery, Thomas A., Aschmies, Suzan, Hirst, Warren D., Kelley, Cody, Kim, Ji-In, Kubek, Katie, Ning, Xiaoping, Platt, Brian J., Robichaud, Albert J., Solvibile, William R., Stock, Joseph R., Tawa, Gregory, Williams, Marla J., Ellingboe, John W.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)

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Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ

by Pellicciari, Roberto, Camaioni, Emidio, Gilbert, Adam M., Macchiarulo, Antonio, Bikker, Jack A., Shah, Falgun, Bard, Joel, Costantino, Gabriele, Gioiello, Antimo, Robertson, Graeme M., Sabbatini, Paola, Venturoni, Francesco, Liscio, Paride, Carotti, Andrea, Bellocchi, Daniele, Cozzi, Andrea, Wood, Andrew, Gonzales, Cathleen, Zaleska, Margaret M., Ellingboe, John W., Moroni, Flavio
Published in MedChemComm (01.06.2011)

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The Organic Chemistry of Drug Design and Drug Action. Second Edition By Richard B. Silverman. Elsevier Academic Press, London. 2004. xix + 617 pp. 19 × 27 cm. ISBN 0-12-643732-7. $80.00

The Organic Chemistry of Drug Design and Drug Action. Second Edition By Richard B. Silverman. Elsevier Academic Press, London. 2004. xix + 617 pp. 19 × 27 cm. ISBN 0-12-643732-7. $80.00

by Ellingboe, John W
Published in Journal of Medicinal Chemistry (21.10.2004)

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Journal Article Book Review

Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H sub(3) receptor antagonists

Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H sub(3) receptor antagonists

by Cole, Derek C, Gross, Jonathan L, Comery, Thomas A, Aschmies, Suzan, Hirst, Warren D, Kelley, Cody, Kim, Ji-In, Kubek, Katie, Ning, Xiaoping, Platt, Brian J, Robichaud, Albert J, Solvibile, William R, Stock, Joseph R, Tawa, Gregory, Williams, Marla J, Ellingboe, John W
Published in Bioorganic & medicinal chemistry letters (01.02.2010)

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Medicinal Chemistry: Today and Tomorrow Edited by Mikio Yamazaki. International Union of Pure and Applied Chemistry, Blackwell Science Ltd., Oxford. 1997. x + 278 pp. 19.5 × 23 cm. ISBN 0-632-04272-9. £55.00

Medicinal Chemistry: Today and Tomorrow Edited by Mikio Yamazaki. International Union of Pure and Applied Chemistry, Blackwell Science Ltd., Oxford. 1997. x + 278 pp. 19.5 × 23 cm. ISBN 0-632-04272-9. £55.00

by Ellingboe, John W
Published in Journal of Medicinal Chemistry (06.05.1999)

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Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent b-secretase (BACE1) inhibitors

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent b-secretase (BACE1) inhibitors

by Nowak, Pawel, Cole, Derek C, Aulabaugh, Ann, Bard, Jonathan, Chopra, Rajiv, Cowling, Rebecca, Fan, Kristi Y, Hu, Baihua, Jacobsen, Steve, Jani, Minakshi, Jin, Guixan, Lo, Mei-Chu, Malamas, Michael S, Manas, Eric S, Narasimhan, Rani, Reinhart, Peter, Robichaud, Albert J, Stock, Joseph R, Subrath, Joan, Svenson, Kristine, Turner, Jim, Wagner, Erik, Zhou, Ping, Ellingboe, John W
Published in Bioorganic & medicinal chemistry letters (15.01.2010)

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Solid-phase synthesis of 2,4,6-trisubstituted pyridines

Solid-phase synthesis of 2,4,6-trisubstituted pyridines

by Chiu, CF, Tang, ZL, Ellingboe, JW
Published in Journal of combinatorial chemistry (01.01.1999)

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Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

by GOPALSAMY, Ariamala, APLASCA, Alexis, CISZEWSKI, Gregory, PARK, Kaapjoo, ELLINGBOE, John W, ORLOWSKI, Mark, FELD, Boris, HOWE, Anita Y. M
Published in Bioorganic & medicinal chemistry letters (2006)

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Design and synthesis of 2,3,4,9-tetrahydro-1 H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[ b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

Design and synthesis of 2,3,4,9-tetrahydro-1 H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[ b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

by Gopalsamy, Ariamala, Shi, Mengxiao, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W., Orlowski, Mark, Feld, Boris, Howe, Anita Y.M.
Published in Bioorganic & medicinal chemistry letters (2006)

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Design and synthesis of 3,4-dihydro-1 H-[1]-benzothieno[2,3- c]pyran and 3,4-dihydro-1 H-pyrano[3,4- b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

Design and synthesis of 3,4-dihydro-1 H-[1]-benzothieno[2,3- c]pyran and 3,4-dihydro-1 H-pyrano[3,4- b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

by Gopalsamy, Ariamala, Aplasca, Alexis, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W., Orlowski, Mark, Feld, Boris, Howe, Anita Y.M.
Published in Bioorganic & medicinal chemistry letters (2006)

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Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist

Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist

by Cole, Derek C, Stock, Joseph R, Lennox, William J, Bernotas, Ronald C, Ellingboe, John W, Boikess, Steve, Coupet, Joseph, Smith, Deborah L, Leung, Louis, Zhang, Guo-Ming, Feng, Xidong, Kelly, Michael F, Galante, Rocco, Huang, Pingzhong, Dawson, Lee A, Marquis, Karen, Rosenzweig-Lipson, Sharon, Beyer, Chad E, Schechter, Lee E
Published in Journal of medicinal chemistry (15.11.2007)

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Discovery of N 1 -(6-Chloroimidazo[2,1- b ][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT 6 Receptor Agonist

Discovery of N 1 -(6-Chloroimidazo[2,1- b ][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT 6 Receptor Agonist

by Cole, Derek C., Stock, Joseph R., Lennox, William J., Bernotas, Ronald C., Ellingboe, John W., Boikess, Steve, Coupet, Joseph, Smith, Deborah L., Leung, Louis, Zhang, Guo-Ming, Feng, Xidong, Kelly, Michael F., Galante, Rocco, Huang, Pingzhong, Dawson, Lee A., Marquis, Karen, Rosenzweig-Lipson, Sharon, Beyer, Chad E., Schechter, Lee E.
Published in Journal of medicinal chemistry (01.11.2007)

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1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors

by Gopalsamy, Ariamala, Yang, Hui, Ellingboe, John W, McKew, John C, Tam, Steve, Joseph-McCarthy, Diane, Zhang, Wen, Shen, Marina, Clark, James D
Published in Bioorganic & medicinal chemistry letters (01.06.2006)

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Acylguanidine inhibitors of beta -secretase: Optimization of the pyrrole ring substituents extending into the S sub(1) and S sub(3) substrate binding pockets

Acylguanidine inhibitors of beta -secretase: Optimization of the pyrrole ring substituents extending into the S sub(1) and S sub(3) substrate binding pockets

by Cole, Derek C, Stock, Joseph R, Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W, Fan, Kristi Y, Harrison, Boyd L, Hu, Yun, Jacobsen, Steve, Jennings, Lee D, Jin, Guixian, Lohse, Peter A, Malamas, Michael S, Manas, Eric S, Moore, William J, O'Donnell, Mary-Margaret, Olland, Andrea M, Robichaud, Albert J, Svenson, Kristine, Wu, JunJun, Wagner, Eric, Bard, Jonathan
Published in Bioorganic & medicinal chemistry (01.02.2008)

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1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A 2α inhibitors

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A 2α inhibitors

by Gopalsamy, Ariamala, Yang, Hui, Ellingboe, John W., McKew, John C., Tam, Steve, Joseph-McCarthy, Diane, Zhang, Wen, Shen, Marina, Clark, James D.
Published in Bioorganic & medicinal chemistry letters (2006)

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