Identification and Characterization of Acidic Mammalian Chitinase Inhibitors
Cole, Derek C, Olland, Andrea M, Jacob, Jaison, Brooks, Jon, Bursavich, Matthew G, Czerwinski, Robert, DeClercq, Charlene, Johnson, Mark, Joseph-McCarthy, Diane, Ellingboe, John W, Lin, Laura, Nowak, Pawel, Presman, Ella, Strand, James, Tam, Amy, Williams, Cara M. M, Yao, Shihua, Tsao, Désirée H. H, Fitz, Lori J
Published in Journal of medicinal chemistry (26.08.2010)
Published in Journal of medicinal chemistry (26.08.2010)
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Journal Article
Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1
Gopalsamy, Ariamala, Kincaid, Scott L., Ellingboe, John W., Groeling, Thomas M., Antrilli, Thomas M., Krishnamurthy, Girija, Aulabaugh, Ann, Friedrichs, Gregory S., Crandall, David L.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Journal Article
Discovery of Potent and Selective Inhibitors of the Mammalian Target of Rapamycin (mTOR) Kinase
Nowak, Pawel, Cole, Derek C, Brooijmans, Natasja, Bursavich, Matthew G, Curran, Kevin J, Ellingboe, John W, Gibbons, James J, Hollander, Irwin, Hu, YongBo, Kaplan, Joshua, Malwitz, David J, Toral-Barza, Lourdes, Verheijen, Jeroen C, Zask, Arie, Zhang, Wei-Guo, Yu, Ker
Published in Journal of medicinal chemistry (26.11.2009)
Published in Journal of medicinal chemistry (26.11.2009)
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Journal Article
Acylguanidines as Small-Molecule β-Secretase Inhibitors
Cole, Derek C, Manas, Eric S, Stock, Joseph R, Condon, Jeffrey S, Jennings, Lee D, Aulabaugh, Ann, Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W, Fan, Kristi Y, Harrison, Boyd L, Hu, Yun, Jacobsen, Steve, Jin, Guixan, Lin, Laura, Lovering, Frank E, Malamas, Michael S, Stahl, Mark L, Strand, James, Sukhdeo, Mohani N, Svenson, Kristine, Turner, M. James, Wagner, Erik, Wu, Junjun, Zhou, Ping, Bard, Jonathan
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Journal Article
Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors
Park, Kaapjoo, Gopalsamy, Ariamala, Aplasca, Alexis, Ellingboe, John W., Xu, Weixin, Zhang, Yuhua, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry (01.06.2009)
Published in Bioorganic & medicinal chemistry (01.06.2009)
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Journal Article
Discovery of 5-Arylsulfonamido-3- (pyrrolidin-2-ylmethyl)-1H-indole Derivatives as Potent, Selective 5-HT6 Receptor Agonists and Antagonists
Cole, Derek C, Lennox, William J, Lombardi, Sabrina, Ellingboe, John W, Bernotas, Ronald C, Tawa, Gregory J, Mazandarani, Hossein, Smith, Deborah L, Zhang, Guoming, Coupet, Joseph, Schechter, Lee E
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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Journal Article
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Chen, Zecheng, Santos, Efren Delos, Dos Santos, Osvaldo, Bursavich, Matthew, Gilbert, Adam M., Ellingboe, John W., Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors
Cole, Derek C, Asselin, Magda, Brennan, Agnes, Czerwinski, Robert, Ellingboe, John W, Fitz, Lori, Greco, Rita, Huang, Xinyi, Joseph-McCarthy, Diane, Kelly, Michael F, Kirisits, Matthew, Lee, Julie, Li, Yuanhong, Morgan, Paul, Stock, Joseph R, Tsao, Désirée H. H, Wissner, Allan, Yang, Xiaoke, Chaudhary, Divya
Published in Journal of medicinal chemistry (09.10.2008)
Published in Journal of medicinal chemistry (09.10.2008)
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Journal Article
Acylguanidine inhibitors of β-secretase : Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets
COLE, Derek C, STOCK, Joseph R, GUIXIAN JIN, LOHSE, Peter A, MALAMAS, Michael S, MANAS, Eric S, MOORE, William J, O'DONNELL, Mary-Margaret, OLLAND, Andrea M, ROBICHAUD, Albert J, SVENSON, Kristine, JUNJUN WU, CHOPRA, Rajiv, WAGNER, Eric, BARD, Jonathan, COWLING, Rebecca, ELLINGBOE, John W, FAN, Kristi Y, HARRISON, Boyd L, YUN HU, JACOBSEN, Steve, JENNINGS, Lee D
Published in Bioorganic & medicinal chemistry letters (01.02.2008)
Published in Bioorganic & medicinal chemistry letters (01.02.2008)
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Journal Article
Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist
Cole, Derek C, Stock, Joseph R, Lennox, William J, Bernotas, Ronald C, Ellingboe, John W, Boikess, Steve, Coupet, Joseph, Smith, Deborah L, Leung, Louis, Zhang, Guo-Ming, Feng, Xidong, Kelly, Michael F, Galante, Rocco, Huang, Pingzhong, Dawson, Lee A, Marquis, Karen, Rosenzweig-Lipson, Sharon, Beyer, Chad E, Schechter, Lee E
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Journal Article
Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site
Gopalsamy, Ariamala, Chopra, Rajiv, Lim, Kitae, Ciszewski, Gregory, Shi, Mengxiao, Curran, Kevin J, Sukits, Steven F, Svenson, Kristine, Bard, Joel, Ellingboe, John W, Agarwal, Atul, Krishnamurthy, Girija, Howe, Anita Y. M, Orlowski, Mark, Feld, Boris, O'Connell, John, Mansour, Tarek S
Published in Journal of medicinal chemistry (01.06.2006)
Published in Journal of medicinal chemistry (01.06.2006)
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Journal Article
Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase
Gopalsamy, Ariamala, Aplasca, Alexis, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W, Orlowski, Mark, Feld, Boris, Howe, Anita Y M
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Journal Article
Design and synthesis of macro-heterocycles structurally related to tirofiban
Ramaseshan, Mahesh, Robitaille, Martin, Ellingboe, John W, Dory, Yves L, Deslongchamps, Pierre
Published in Tetrahedron letters (01.06.2000)
Published in Tetrahedron letters (01.06.2000)
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Journal Article
Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors
Gopalsamy, Ariamala, Lim, Kitae, Ciszewski, Gregory, Park, Kaapjoo, Ellingboe, John W, Bloom, Jonathan, Insaf, Shabana, Upeslacis, Janis, Mansour, Tarek S, Krishnamurthy, Girija, Damarla, Murthy, Pyatski, Yelena, Ho, Douglas, Howe, Anita Y. M, Orlowski, Mark, Feld, Boris, O'Connell, John
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Journal Article
Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors
Nowak, Pawel, Cole, Derek C., Aulabaugh, Ann, Bard, Jonathan, Chopra, Rajiv, Cowling, Rebecca, Fan, Kristi Y., Hu, Baihua, Jacobsen, Steve, Jani, Minakshi, Jin, Guixan, Lo, Mei-Chu, Malamas, Michael S., Manas, Eric S., Narasimhan, Rani, Reinhart, Peter, Robichaud, Albert J., Stock, Joseph R., Subrath, Joan, Svenson, Kristine, Turner, Jim, Wagner, Erik, Zhou, Ping, Ellingboe, John W.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Pyrazolo[1,5- a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region
Gopalsamy, Ariamala, Yang, Hui, Ellingboe, John W., Tsou, Hwei-Ru, Zhang, Nan, Honores, Erick, Powell, Dennis, Miranda, Miriam, McGinnis, John P., Rabindran, Sridhar K.
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
Published in Bioorganic & medicinal chemistry letters (15.03.2005)
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Journal Article
Identification of a new class of small molecule C5a receptor antagonists
Chen, Jack J., Cole, Derek C., Ciszewski, Greg, Crouse, Kimberly, Ellingboe, John W., Nowak, Pawel, Tawa, Gregory J., Berstein, Gabriel, Li, Wei
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Acylguanidine inhibitors of β-secretase : Optimization of the pyrrole ring substituents extending into the S'1 substrate binding pocket
JENNINGS, Lee D, COLE, Derek C, HARRISON, Boyd L, JACOBSEN, Steve, CHOPRA, Rajiv, LOHSE, Peter A, MOORE, William J, O'DONNELL, Mary-Margaret, YUN HU, ROBICHAUD, Albert J, TURNER, M. James, WAGNER, Erik, STOCK, Joseph R, BARD, Jonathan, SUKHDEO, Mohani N, ELLINGBOE, John W, COWLING, Rebecca, GUIXIAN JIN, MANAS, Eric S, FAN, Kristi Y, MALAMAS, Michael S
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
Published in Bioorganic & medicinal chemistry letters (15.01.2008)
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Journal Article
Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists
COLE, Derek C, GROSS, Jonathan L, ROBICHAUD, Albert J, SOLVIBILE, William R, STOCK, Joseph R, TAWA, Gregory, WILLIAMS, Marla J, ELLINGBOE, John W, COMERY, Thomas A, ASCHMIES, Suzan, HIRST, Warren D, KELLEY, Cody, KIM, Ji-In, KUBEK, Katie, XIAOPING NING, PLATT, Brian J
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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