Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes
Mandler, Michael D., Mignone, James, Jurica, Elizabeth A., Palkowitz, Maximilian D., Aulakh, Darpandeep, Cauley, Anthony N., Farley, Christopher A., Zhang, Shasha, Traeger, Sarah C., Sarjeant, Amy, Paiva, Anthony, Perez, Heidi L., Ellsworth, Bruce A., Regueiro-Ren, Alicia
Published in Organic letters (10.11.2023)
Published in Organic letters (10.11.2023)
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Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities
Jurica, Elizabeth A., Wu, Ximao, Williams, Kristin N., Haque, Lauren E., Rampulla, Richard A., Mathur, Arvind, Zhou, Min, Cao, Gary, Cai, Hong, Wang, Tao, Liu, Heng, Xu, Carrie, Kunselman, Lori K., Antrilli, Thomas M., Hicks, Michael B., Sun, Qin, Dierks, Elizabeth A., Apedo, Atsu, Moore, Douglas B., Foster, Kimberly A., Cvijic, Mary Ellen, Panemangalore, Reshma, Khandelwal, Purnima, Wilkes, Jason J., Zinker, Bradley A., Robertson, Donald G., Janovitz, Evan B., Galella, Michael, Li, Yi-Xin, Li, Julia, Ramar, Thangeswaran, Jalagam, Prasada Rao, Jayaram, Ramya, Whaley, Jean M., Barrish, Joel C., Robl, Jeffrey A., Ewing, William R., Ellsworth, Bruce A.
Published in Bioorganic & medicinal chemistry (01.05.2023)
Published in Bioorganic & medicinal chemistry (01.05.2023)
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Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode
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Published in Journal of medicinal chemistry (23.02.2017)
Published in Journal of medicinal chemistry (23.02.2017)
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Evolution of the Synthetic Process to an Advanced GPR40 Agonist
Hou, Xiaoping, Hernandez, Lucas W., Jurica, Elizabeth A., Zhao, Rulin, Wang, Bei, Wong, Michael, Sun, Jung-Hui, Sun, Dawn, Wu, Dauh-Rurng, Yuan, Changxia, Hay, Michael, Yu, Miao, Wu, Ximao, Huang, Yanting, Ellsworth, Bruce A., Bobes, Francisco Gonzalez, Mathur, Arvind, Kempson, James
Published in Organic process research & development (19.01.2024)
Published in Organic process research & development (19.01.2024)
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