Molecular basis for inhibiting human glucose transporters by exofacial inhibitors
Wang, Nan, Zhang, Shuo, Yuan, Yafei, Xu, Hanwen, Defossa, Elisabeth, Matter, Hans, Besenius, Melissa, Derdau, Volker, Dreyer, Matthias, Halland, Nis, He, Kaihui Hu, Petry, Stefan, Podeschwa, Michael, Tennagels, Norbert, Jiang, Xin, Yan, Nieng
Published in Nature communications (12.05.2022)
Published in Nature communications (12.05.2022)
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Journal Article
Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes
Klabunde, Thomas, Wendt, K. Ulrich, Kadereit, Dieter, Brachvogel, Volker, Burger, Hans-Jörg, Herling, Andreas W, Oikonomakos, Nikos G, Kosmopoulou, Magda N, Schmoll, Dieter, Sarubbi, Edoardo, von Roedern, Erich, Schönafinger, Karl, Defossa, Elisabeth
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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Journal Article
Design, Synthesis, and Pharmacological Evaluation of Potent Positive Allosteric Modulators of the Glucagon-like Peptide‑1 Receptor (GLP-1R)
Méndez, María, Matter, Hans, Defossa, Elisabeth, Kurz, Michael, Lebreton, Sylvain, Li, Ziyu, Lohmann, Matthias, Löhn, Matthias, Mors, Hartmut, Podeschwa, Michael, Rackelmann, Nils, Riedel, Jens, Safar, Pavel, Thorpe, David S, Schäfer, Matthias, Weitz, Dietmar, Breitschopf, Kristin
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
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Journal Article
Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites
Ackerson, Timothy, Amberg, Alexander, Atzrodt, Jens, Arabeyre, Catherine, Defossa, Elisabeth, Dorau, Martina, Dudda, Angela, Dwyer, Jacquelyn, Holla, Wolfgang, Kissner, Thomas, Kohlmann, Markus, Kürzel, Ulrich, Pánczél, József, Rajanna, Shibani, Riedel, Jens, Schmidt, Friedemann, Wäse, Kerstin, Weitz, Dietmar, Derdau, Volker
Published in Journal of biochemical and molecular toxicology (01.08.2019)
Published in Journal of biochemical and molecular toxicology (01.08.2019)
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Journal Article
Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method
Bartoschek, Stefan, Klabunde, Thomas, Defossa, Elisabeth, Dietrich, Viktoria, Stengelin, Siegfried, Griesinger, Christian, Carlomagno, Teresa, Focken, Ingo, Wendt, K. Ulrich
Published in Angewandte Chemie (International ed.) (15.02.2010)
Published in Angewandte Chemie (International ed.) (15.02.2010)
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Journal Article
Thermodynamic Characterization of Allosteric Glycogen Phosphorylase Inhibitors
Anderka, Oliver, Loenze, Petra, Klabunde, Thomas, Dreyer, Matthias K, Defossa, Elisabeth, Wendt, K. Ulrich, Schmoll, Dieter
Published in Biochemistry (Easton) (22.04.2008)
Published in Biochemistry (Easton) (22.04.2008)
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Journal Article
Design and Quantitative Structure−Activity Relationship of 3-Amidinobenzyl-1H-indole-2-carboxamides as Potent, Nonchiral, and Selective Inhibitors of Blood Coagulation Factor Xa
Matter, Hans, Defossa, Elisabeth, Heinelt, Uwe, Blohm, Peter-Michael, Schneider, Detlev, Müller, Andrea, Herok, Silke, Schreuder, Herman, Liesum, Alexander, Brachvogel, Volker, Lönze, Petra, Walser, Armin, Al-Obeidi, Fahad, Wildgoose, Peter
Published in Journal of medicinal chemistry (20.06.2002)
Published in Journal of medicinal chemistry (20.06.2002)
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Journal Article
Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Oikonomakos, Nikos G., Kosmopoulou, Magda N., Chrysina, Evangelia D., Leonidas, Demetres D., Kostas, Ioannis D., Wendt, K. Ulrich, Klabunde, Thomas, Defossa, Elisabeth
Published in Protein science (01.07.2005)
Published in Protein science (01.07.2005)
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Journal Article
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
SZILLAT, Hauke, HEINELT, Uwe, RACKELMANN, Nils, MENDEZ-PEREZ, Maria, RITTER, Kurt, DEFOSSA, Elisabeth, ZECH, Gernot, MATTER, Hans
Year of Publication 18.09.2024
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Year of Publication 18.09.2024
Patent
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
SZILLAT, Hauke, HEINELT, Uwe, RACKELMANN, Nils, MENDEZ-PEREZ, Maria, RITTER, Kurt, DEFOSSA, Elisabeth, ZECH, Gernot, MATTER, Hans
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
SZILLAT, Hauke, HEINELT, Uwe, RACKELMANN, Nils, MENDEZ-PEREZ, Maria, RITTER, Kurt, DEFOSSA, Elisabeth, ZECH, Gernot, MATTER, Hans
Year of Publication 04.04.2024
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Year of Publication 04.04.2024
Patent
Drug Design for G-Protein-Coupled Receptors by a Ligand-Based NMR Method
Bartoschek, Stefan, Klabunde, Thomas, Defossa, Elisabeth, Dietrich, Viktoria, Stengelin, Siegfried, Griesinger, Christian, Carlomagno, Teresa, Focken, Ingo, Wendt, K. Ulrich
Published in Angewandte Chemie (15.02.2010)
Published in Angewandte Chemie (15.02.2010)
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Journal Article
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
SCHIELL, Matthias, HEINELT, Uwe, RACKELMANN, Nils, GRIESANG, Niels, DEFOSSA, Elisabeth, MENDEZ PEREZ, Maria, PANCZEL, Jozsef, MATTER, Hans
Year of Publication 22.02.2024
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Year of Publication 22.02.2024
Patent
Isoxazolidines as RIPK1 inhibitors and use thereof
Defossa, Elisabeth, Mendez-Perez, Maria, Rackelmann, Nils, Szillat, Hauke, Ritter, Kurt, Heinelt, Uwe, Matter, Hans, Zech, Gernot
Year of Publication 13.02.2024
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Year of Publication 13.02.2024
Patent
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
SZILLAT, Hauke, HEINELT, Uwe, RACKELMANN, Nils, MENDEZ-PEREZ, Maria, RITTER, Kurt, DEFOSSA, Elisabeth, ZECH, Gernot, MATTER, Hans
Year of Publication 29.06.2023
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Year of Publication 29.06.2023
Patent
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
HEINELT, UWE, SZILLAT, HAUKE, DEFOSSA, ELISABETH, RACKELMANN, NILS, ZECH, GERNOT, RITTER, KURT, MENDEZ-PEREZ, MARIA, MATTER, HANS
Year of Publication 19.05.2023
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Year of Publication 19.05.2023
Patent
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
SZILLAT, Hauke, HEINELT, Uwe, RACKELMANN, Nils, MENDEZ-PEREZ, Maria, RITTER, Kurt, DEFOSSA, Elisabeth, ZECH, Gernot, MATTER, Hans
Year of Publication 19.05.2023
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Year of Publication 19.05.2023
Patent
ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF
GLOMBIK, Heiner, SZILLAT, Hauke, HEINELT, Uwe, SCHWINK, Lothar, RACKELMANN, Nils, MENDEZ-PEREZ, Maria, RITTER, Kurt, DEFOSSA, Elisabeth, ZECH, Gernot, MATTER, Hans
Year of Publication 13.07.2023
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Year of Publication 13.07.2023
Patent