Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle
Eliasof, Scott, Lazarus, Douglas, Peters, Christian G., Case, Roy I., Cole, Roderic O., Hwang, Jungyeon, Schluep, Thomas, Chao, Joseph, Lin, James, Yen, Yun, Han, Han, Wiley, Devin T., Zuckerman, Jonathan E., Davis, Mark E.
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2013)
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Journal Article
CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development
Young, Cissy, Schluep, Thomas, Hwang, Jungyeon, Eliasof, Scott
Published in Current bioactive compounds (01.03.2011)
Published in Current bioactive compounds (01.03.2011)
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Journal Article
Small molecules, big players : the national cancer institute's initiative for chemical genetics
TOLLIDAY, Nicola, CLEMONS, Paul A, FERRAIOLO, Paul, KOEHLER, Angela N, LEWIS, Timothy A, XIAOHUA LI, SCHREIBER, Stuart L, GERHARD, Daniela S, ELIASOF, Scott
Published in Cancer research (Chicago, Ill.) (15.09.2006)
Published in Cancer research (Chicago, Ill.) (15.09.2006)
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Journal Article
Sulfhydryl Modification of V449C in the Glutamate Transporter EAAT1 Abolishes Substrate Transport but not the Substrate-Gated Anion Conductance
Seal, Rebecca P., Shigeri, Yasushi, Eliasof, Scott, Leighton, Barbara H., Amara, Susan G.
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (18.12.2001)
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Journal Article
WAY‐855 (3‐amino‐tricyclo[2.2.1.02.6]heptane‐1,3‐dicarboxylic acid): a novel, EAAT2‐preferring, nonsubstrate inhibitor of high‐affinity glutamate uptake
Dunlop, John, Eliasof, Scott, Stack, Gary, McIlvain, H Beal, Greenfield, Alexander, Kowal, Dianne, Petroski, Robert, Carrick, Tikva
Published in British journal of pharmacology (01.11.2003)
Published in British journal of pharmacology (01.11.2003)
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Journal Article
Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101
Svenson, Sonke, Wolfgang, Marc, Hwang, Jungyeon, Ryan, John, Eliasof, Scott
Published in Journal of controlled release (15.07.2011)
Published in Journal of controlled release (15.07.2011)
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Journal Article
Conference Proceeding
Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy
Rey, Sergio, Schito, Luana, Wouters, Bradly G, Eliasof, Scott, Kerbel, Robert S
Published in Trends in cancer (01.07.2017)
Published in Trends in cancer (01.07.2017)
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Journal Article
CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α
Tian, Xi, Nguyen, Minh, Foote, Henry P, Caster, Joseph M, Roche, Kyle C, Peters, Christian G, Wu, Pauline, Jayaraman, Lata, Garmey, Edward G, Tepper, Joel E, Eliasof, Scott, Wang, Andrew Z
Published in Cancer research (Chicago, Ill.) (01.01.2017)
Published in Cancer research (Chicago, Ill.) (01.01.2017)
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Journal Article
Abstract 4582: CRLX522, a novel dynamic tumor-targeted cabazitaxel nanopharmaceutical
Lazarus, Douglas, Kabir, Sujan, Eliasof, Scott
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 3209: CRLX101, an investigational nanoparticle-drug conjugate of camptothecin, demonstrates synergy with immunotherapy agents in preclinical models
Lazarus, Douglas, Peters, Christian, Stockmann, Adam, Eliasof, Scott, Jayaraman, Lata
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer
Pham, Elizabeth, Yin, Melissa, Peters, Christian G, Lee, Christina R, Brown, Donna, Xu, Ping, Man, Shan, Jayaraman, Lata, Rohde, Ellen, Chow, Annabelle, Lazarus, Douglas, Eliasof, Scott, Foster, F Stuart, Kerbel, Robert S
Published in Cancer research (Chicago, Ill.) (01.08.2016)
Published in Cancer research (Chicago, Ill.) (01.08.2016)
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Journal Article
Translational impact of nanoparticle-drug conjugate CRLX101 with or without bevacizumab in advanced ovarian cancer
Pham, Elizabeth, Birrer, Michael J, Eliasof, Scott, Garmey, Edward G, Lazarus, Douglas, Lee, Christina R, Man, Shan, Matulonis, Ursula A, Peters, Christian G, Xu, Ping, Krasner, Carolyn, Kerbel, Robert S
Published in Clinical cancer research (15.02.2015)
Published in Clinical cancer research (15.02.2015)
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Journal Article
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer
Conley, Sarah J., Baker, Trenton L., Burnett, Joseph P., Theisen, Rebecca L., Lazarus, Douglas, Peters, Christian G., Clouthier, Shawn G., Eliasof, Scott, Wicha, Max S.
Published in Breast cancer research and treatment (01.04.2015)
Published in Breast cancer research and treatment (01.04.2015)
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Journal Article
Abstract CT090: Phase II trial of the NDC CRLX101 in combination with bevacizumab in patients with platinum-resistant ovarian cancer (PROC)
Krasner, Carolyn, Birrer, Michael, Peters, Christian, Jayaraman, Lata, Eliasof, Scott, Tellez, Andres, Downing, William, Senderowicz, Adrian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 5643: CRLX301, a novel tumor-targeted taxane nanopharmaceutical
Lazarus, Douglas, Kabir, Sujan, Eliasof, Scott
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Discovery of a Novel Cabazitaxel Nanoparticle–Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β‑Cyclodextrin–PEG Copolymer Based Delivery Platform
Metcalf, Chester A, Svenson, Sonke, Hwang, Jungyeon, Tripathi, Snehlata, Gangal, Geeti, Kabir, Sujan, Lazarus, Douglas, Cole, Roderic, Sweryda-Krawiec, Beata, Shum, Pochi, Brown, Donna, Case, Roy I, van der Poll, Derek, Rohde, Ellen, Harlfinger, Stephanie, Teng, Chi-Hse, Eliasof, Scott
Published in Journal of medicinal chemistry (14.11.2019)
Published in Journal of medicinal chemistry (14.11.2019)
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Journal Article
Abstract 1345: Tumor selective localization of CRLX101, an investigational nanoparticle-drug conjugate of camptothecin
Peters, Christian G., Lazarus, Douglas, Brown, Donna, Zhang, Ningning, Stockmann, Adam P., Case, Roy, Rohde, Ellen, Eliasof, Scott, Jayaraman, Lata
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article