The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents
Canon, Jude, Osgood, Tao, Olson, Steven H, Saiki, Anne Y, Robertson, Rebecca, Yu, Dongyin, Eksterowicz, John, Ye, Qiuping, Jin, Lixia, Chen, Ada, Zhou, Jing, Cordover, David, Kaufman, Stephen, Kendall, Richard, Oliner, Jonathan D, Coxon, Angela, Radinsky, Robert
Published in Molecular cancer therapeutics (01.03.2015)
Published in Molecular cancer therapeutics (01.03.2015)
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Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Characterization of the active site properties of CYP4F12
Eksterowicz, John, Rock, Dan A, Rock, Brooke M, Wienkers, Larry C, Foti, Robert S
Published in Drug metabolism and disposition (01.10.2014)
Published in Drug metabolism and disposition (01.10.2014)
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Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo
Spencer, Jeffrey R., Sendzik, Martin, Oeh, Jason, Sabbatini, Peter, Dalrymple, Stacie A., Magill, Catherine, Kim, Hyunjin M., Zhang, Penglie, Squires, Neil, Moss, Katherine G., Sukbuntherng, Juthamas, Graupe, Doris, Eksterowicz, John, Young, Peter R., Myers, Andrew G., Green, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Evaluation of a Novel Shape-Based Computational Filter for Lead Evolution: Application to Thrombin Inhibitors
Srinivasan, Jayashree, Castellino, Angelo, Bradley, Erin K, Eksterowicz, John E, Grootenhuis, Peter D. J, Putta, Santosh, Stanton, Robert V
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Coupling structure-based design with combinatorial chemistry: application of active site derived pharmacophores with informative library design
Eksterowicz, John E., Evensen, Erik, Lemmen, Christian, Patrick Brady, G., Kevin Lanctot, J., Bradley, Erin K., Saiah, Eddine, Robinson, Leslie A., Grootenhuis, Peter D.J., Blaney, Jeffrey M.
Published in Journal of molecular graphics & modelling (01.06.2002)
Published in Journal of molecular graphics & modelling (01.06.2002)
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Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)
Min, Xiaoshan, Ungureanu, Daniela, Maxwell, Sarah, Hammarén, Henrik, Thibault, Steve, Hillert, Ellin-Kristina, Ayres, Merrill, Greenfield, Brad, Eksterowicz, John, Gabel, Chris, Walker, Nigel, Silvennoinen, Olli, Wang, Zhulun
Published in The Journal of biological chemistry (06.11.2015)
Published in The Journal of biological chemistry (06.11.2015)
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Journal Article
Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production
Du, Xiaohui, Moore, Jared, Blank, Brian R, Eksterowicz, John, Sutimantanapi, Dena, Yuen, Natalie, Metzger, Todd, Chan, Brenda, Huang, Tom, Chen, Xi, Chen, Yuping, Duong, Frank, Kong, Wayne, Chang, Jae H, Sun, Jessica, Zavorotinskaya, Tatiana, Ye, Qiuping, Junttila, Melissa R, Ndubaku, Chudi, Friedman, Lori S, Fantin, Valeria R, Sun, Daqing
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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On the Regioselectivity of Photocycloadditions of Triplet Cyclohexenones to Alkenes
Broeker, Jeffrey L, Eksterowicz, John E, Belk, Anna J, Houk, K. N
Published in Journal of the American Chemical Society (01.02.1995)
Published in Journal of the American Chemical Society (01.02.1995)
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Conformational preferences of the O-C-C-C unit in acyclic and cyclic systems. The exo-deoxoanomeric effect and related phenomena
Houk, K. N, Eksterowicz, John E, Wu, Yun Dong, Fuglesang, Christopher D, Mitchell, Darren B
Published in Journal of the American Chemical Society (01.05.1993)
Published in Journal of the American Chemical Society (01.05.1993)
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Abstract 3822: ORIC-101 reverses a GR-driven EMT-like phenotype and sensitizes TNBC cells to chemotherapy
Zhou, Haiying, Sun, Jessica, Kong, Wayne, Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Sun, Daqing, Ye, Qiuping, Kabbarah, Omar, Fantin, Valeria R.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)
Rew, Yosup, Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Jahchan, Nadine, Zhu, Liusheng, Yan, Xuelei, Kawai, Hiroyuki, McGee, Lawrence R, Medina, Julio C, Huang, Tom, Chen, Chelsea, Zavorotinskaya, Tatiana, Sutimantanapi, Dena, Waszczuk, Joanna, Jackson, Erica, Huang, Elizabeth, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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Analysis of Kinase Inhibitor Selectivity using a Thermodynamics-Based Partition Index
Cheng, Alan C, Eksterowicz, John, Geuns-Meyer, Stephanie, Sun, Yaxiong
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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Journal Article
Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction
Gonzalez, Ana Z, Eksterowicz, John, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Duquette, Jason, Fox, Brian M, Fu, Jiasheng, Huang, Xin, Houze, Jonathan B, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, McMinn, Dustin L, Oliner, Jonathan D, Osgood, Tao, Rew, Yosup, Saiki, Anne Y, Shaffer, Paul, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Olson, Steven H, Medina, Julio C, Sun, Daqing
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633)
Du, Xiaohui, Eksterowicz, John, Zhou, Haiying, Rew, Yosup, Zhu, Liusheng, Yan, Xuelei, Medina, Julio C, Huang, Tom, Chen, Xi, Sutimantanapi, Dena, Jahchan, Nadine, Kong, Wayne, Sun, Jessica, Zavorotinskaya, Tatiana, Ye, Qiuping, Fantin, Valeria R, Sun, Daqing
Published in Journal of medicinal chemistry (25.07.2019)
Published in Journal of medicinal chemistry (25.07.2019)
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Journal Article
Discovery of AM-7209, a Potent and Selective 4‑Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Yan, Xuelei, Beck, Hilary P, Canon, Jude, Chen, Ada, Duquette, Jason, Eksterowicz, John, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Houze, Jonathan, Huang, Xin, Jiang, Min, Jin, Lixia, Li, Yihong, Li, Zhihong, Ling, Yun, Lo, Mei-Chu, Long, Alexander M, McGee, Lawrence R, McIntosh, Joel, Oliner, Jonathan D, Osgood, Tao, Saiki, Anne Y, Shaffer, Paul, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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