Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
Pirinen, Eija, Auranen, Mari, Khan, Nahid A., Brilhante, Virginia, Urho, Niina, Pessia, Alberto, Hakkarainen, Antti, Kuula, Juho, Heinonen, Ulla, Schmidt, Mark S., Haimilahti, Kimmo, Piirilä, Päivi, Lundbom, Nina, Taskinen, Marja-Riitta, Brenner, Charles, Velagapudi, Vidya, Pietiläinen, Kirsi H., Suomalainen, Anu
Published in Cell metabolism (02.06.2020)
Published in Cell metabolism (02.06.2020)
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NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
Cerutti, Raffaele, Pirinen, Eija, Lamperti, Costanza, Marchet, Silvia, Sauve, Anthony A., Li, Wei, Leoni, Valerio, Schon, Eric A., Dantzer, Françoise, Auwerx, Johan, Viscomi, Carlo, Zeviani, Massimo
Published in Cell metabolism (03.06.2014)
Published in Cell metabolism (03.06.2014)
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Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
Khan, Nahid A, Auranen, Mari, Paetau, Ilse, Pirinen, Eija, Euro, Liliya, Forsström, Saara, Pasila, Lotta, Velagapudi, Vidya, Carroll, Christopher J, Auwerx, Johan, Suomalainen, Anu
Published in EMBO molecular medicine (01.06.2014)
Published in EMBO molecular medicine (01.06.2014)
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The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance
Vannini, Nicola, Campos, Vasco, Girotra, Mukul, Trachsel, Vincent, Rojas-Sutterlin, Shanti, Tratwal, Josefine, Ragusa, Simone, Stefanidis, Evangelos, Ryu, Dongryeol, Rainer, Pernille Y., Nikitin, Gena, Giger, Sonja, Li, Terytty Y., Semilietof, Aikaterini, Oggier, Aurelien, Yersin, Yannick, Tauzin, Loïc, Pirinen, Eija, Cheng, Wan-Chen, Ratajczak, Joanna, Canto, Carles, Ehrbar, Martin, Sizzano, Federico, Petrova, Tatiana V., Vanhecke, Dominique, Zhang, Lianjun, Romero, Pedro, Nahimana, Aimable, Cherix, Stephane, Duchosal, Michel A., Ho, Ping-Chih, Deplancke, Bart, Coukos, George, Auwerx, Johan, Lutolf, Matthias P., Naveiras, Olaia
Published in Cell stem cell (07.03.2019)
Published in Cell stem cell (07.03.2019)
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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Kraus, Daniel, Yang, Qin, Kong, Dong, Banks, Alexander S., Zhang, Lin, Rodgers, Joseph T., Pirinen, Eija, Pulinilkunnil, Thomas C., Gong, Fengying, Wang, Ya-chin, Cen, Yana, Sauve, Anthony A., Asara, John M., Peroni, Odile D., Monia, Brett P., Bhanot, Sanjay, Alhonen, Leena, Puigserver, Pere, Kahn, Barbara B.
Published in Nature (London) (10.04.2014)
Published in Nature (London) (10.04.2014)
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NAD+ repletion with niacin counteracts cancer cachexia
Beltrà, Marc, Pöllänen, Noora, Fornelli, Claudia, Tonttila, Kialiina, Hsu, Myriam Y., Zampieri, Sandra, Moletta, Lucia, Corrà, Samantha, Porporato, Paolo E., Kivelä, Riikka, Viscomi, Carlo, Sandri, Marco, Hulmi, Juha J., Sartori, Roberta, Pirinen, Eija, Penna, Fabio
Published in Nature communications (03.04.2023)
Published in Nature communications (03.04.2023)
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Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
Wang, Hong, Kuusela, Sara, Rinnankoski-Tuikka, Rita, Dumont, Vincent, Bouslama, Rim, Ramadan, Usama Abo, Waaler, Jo, Linden, Anni-Maija, Chi, Nai-Wen, Krauss, Stefan, Pirinen, Eija, Lehtonen, Sanna
Published in International Journal of Obesity (01.08.2020)
Published in International Journal of Obesity (01.08.2020)
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Human HDL subclasses modulate energy metabolism in skeletal muscle cells
Lund, Jenny, Lähteenmäki, Emilia, Eklund, Tiia, Bakke, Hege G, Thoresen, G Hege, Pirinen, Eija, Jauhiainen, Matti, Rustan, Arild C, Lehti, Maarit
Published in Journal of lipid research (01.01.2024)
Published in Journal of lipid research (01.01.2024)
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Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle
Pirinen, Eija, Cantó, Carles, Jo, Young Suk, Morato, Laia, Zhang, Hongbo, Menzies, Keir J., Williams, Evan G., Mouchiroud, Laurent, Moullan, Norman, Hagberg, Carolina, Li, Wei, Timmers, Silvie, Imhof, Ralph, Verbeek, Jef, Pujol, Aurora, van Loon, Barbara, Viscomi, Carlo, Zeviani, Massimo, Schrauwen, Patrick, Sauve, Anthony A., Schoonjans, Kristina, Auwerx, Johan
Published in Cell metabolism (03.06.2014)
Published in Cell metabolism (03.06.2014)
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Journal Article
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
Pirinen, Eija, Auranen, Mari, Khan, Nahid A., Brilhante, Virginia, Urho, Niina, Pessia, Alberto, Hakkarainen, Antti, Ulla Heinonen, Juho Kuula, Schmidt, Mark S., Haimilahti, Kimmo, Piirilä, Päivi, Lundbom, Nina, Taskinen, Marja-Riitta, Brenner, Charles, Velagapudi, Vidya, Pietiläinen, Kirsi H., Suomalainen, Anu
Published in Cell metabolism (07.07.2020)
Published in Cell metabolism (07.07.2020)
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Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans
van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, Williams, Evan G, Ropelle, Eduardo R, Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M, Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B, Hesselink, Matthijs K C, Auwerx, Johan, Roden, Michael, Schrauwen, Patrick
Published in Diabetes (New York, N.Y.) (01.04.2015)
Published in Diabetes (New York, N.Y.) (01.04.2015)
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
Item, Flurin, Wueest, Stephan, Lemos, Vera, Stein, Sokrates, Lucchini, Fabrizio C., Denzler, Rémy, Fisser, Muriel C., Challa, Tenagne D., Pirinen, Eija, Kim, Youngsoo, Hemmi, Silvio, Gulbins, Erich, Gross, Atan, O’Reilly, Lorraine A., Stoffel, Markus, Auwerx, Johan, Konrad, Daniel
Published in Nature communications (07.09.2017)
Published in Nature communications (07.09.2017)
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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
Fernandez-Marcos, Pablo J., Jeninga, Ellen H., Canto, Carles, Harach, Taoufiq, de Boer, Vincent C. J., Andreux, Penelope, Moullan, Norman, Pirinen, Eija, Yamamoto, Hiroyasu, Houten, Sander M., Schoonjans, Kristina, Auwerx, Johan
Published in Scientific reports (28.05.2012)
Published in Scientific reports (28.05.2012)
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Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
U-Din, Mueez, de Mello, Vanessa D., Tuomainen, Marjo, Raiko, Juho, Niemi, Tarja, Fromme, Tobias, Klåvus, Anton, Gautier, Nadine, Haimilahti, Kimmo, Lehtonen, Marko, Kristiansen, Karsten, Newman, John W., Pietiläinen, Kirsi H., Pihlajamäki, Jussi, Amri, Ez-Zoubir, Klingenspor, Martin, Nuutila, Pirjo, Pirinen, Eija, Hanhineva, Kati, Virtanen, Kirsi A.
Published in Cell reports (Cambridge) (01.09.2023)
Published in Cell reports (Cambridge) (01.09.2023)
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Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes
Herbers, Elena, Patrikoski, Mimmi, Wagner, Anita, Jokinen, Riikka, Hassinen, Antti, Heinonen, Sini, Miettinen, Susanna, Peltoniemi, Hilkka, Pirinen, Eija, Pietiläinen, Kirsi H.
Published in Stem cells international (2022)
Published in Stem cells international (2022)
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Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease
Turconi, Giorgio, Alam, Farhan, SenGupta, Tanima, Pirnes-Karhu, Sini, Olfat, Soophie, Schmidt, Mark S., Mätlik, Kärt, Montaño-Rodriguez, Ana, Heiskanen, Vladimir, Garton, Daniel, Piepponen, Petteri T., Brenner, Charles, Holmberg, Carina I., Nilsen, Hilde, Pirinen, Eija, Andressoo, Jaan-Olle
Published in Heliyon (30.07.2024)
Published in Heliyon (30.07.2024)
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Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism
Pirinen, Eija, Kuulasmaa, Teemu, Pietilä, Marko, Heikkinen, Sami, Tusa, Maija, Itkonen, Paula, Boman, Susanna, Skommer, Joanna, Virkamäki, Antti, Hohtola, Esa, Kettunen, Mikko, Fatrai, Szabolcs, Kansanen, Emilia, Koota, Suvi, Niiranen, Kirsi, Parkkinen, Jyrki, Levonen, Anna-Liisa, Ylä-Herttuala, Seppo, Hiltunen, J. Kalervo, Alhonen, Leena, Smith, Ulf, Jänne, Juhani, Laakso, Markku
Published in Molecular and Cellular Biology (01.07.2007)
Published in Molecular and Cellular Biology (01.07.2007)
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Spermidine is indispensable in differentiation of 3T3‐L1 fibroblasts to adipocytes
Vuohelainen, Susanna, Pirinen, Eija, Cerrada‐Gimenez, Marc, Keinänen, Tuomo A., Uimari, Anne, Pietilä, Marko, Khomutov, Alex R., Jänne, Juhani, Alhonen, Leena
Published in Journal of cellular and molecular medicine (01.06.2010)
Published in Journal of cellular and molecular medicine (01.06.2010)
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