Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Ellingsgaard, Helga, Hauselmann, Irina, Schuler, Beat, Habib, Abdella M, Baggio, Laurie L, Meier, Daniel T, Eppler, Elisabeth, Bouzakri, Karim, Wueest, Stephan, Muller, Yannick D, Hansen, Ann Maria Kruse, Reinecke, Manfred, Konrad, Daniel, Gassmann, Max, Reimann, Frank, Halban, Philippe A, Gromada, Jesper, Drucker, Daniel J, Gribble, Fiona M, Ehses, Jan A, Donath, Marc Y
Published in Nature medicine (01.11.2011)
Published in Nature medicine (01.11.2011)
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Journal Article
Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus
Larsen, Claus M, Faulenbach, Mirjam, Vaag, Allan, Vølund, Aage, Ehses, Jan A, Seifert, Burkhardt, Mandrup-Poulsen, Thomas, Donath, Marc Y
Published in The New England journal of medicine (12.04.2007)
Published in The New England journal of medicine (12.04.2007)
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Journal Article
Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes
Larsen, Claus M, Faulenbach, Mirjam, Vaag, Allan, Ehses, Jan A, Donath, Marc Y, Mandrup-Poulsen, Thomas
Published in Diabetes care (01.09.2009)
Published in Diabetes care (01.09.2009)
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Journal Article
TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6
Nackiewicz, Dominika, Dan, Meixia, He, Wei, Kim, Rosa, Salmi, Anisa, Rütti, Sabine, Westwell-Roper, Clara, Cunningham, Amanda, Speck, Madeleine, Schuster-Klein, Carole, Guardiola, Beatrice, Maedler, Kathrin, Ehses, Jan A.
Published in Diabetologia (01.08.2014)
Published in Diabetologia (01.08.2014)
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Journal Article
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
Westwell-Roper, Clara, Dai, Derek L, Soukhatcheva, Galina, Potter, Kathryn J, van Rooijen, Nico, Ehses, Jan A, Verchere, C Bruce
Published in The Journal of immunology (1950) (01.09.2011)
Published in The Journal of immunology (1950) (01.09.2011)
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Journal Article
Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I
Böni-Schnetzler, Marianne, Boller, Simone, Debray, Sarah, Bouzakri, Karim, Meier, Daniel T, Prazak, Richard, Kerr-Conte, Julie, Pattou, Francois, Ehses, Jan A, Schuit, Frans C, Donath, Marc Y
Published in Endocrinology (Philadelphia) (01.12.2009)
Published in Endocrinology (Philadelphia) (01.12.2009)
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Journal Article
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
EHSES, Jan A, PERREN, Aurel, FONTANA, Adriano, REINECKE, Manfred, HOMO-DELARCHE, Francoise, DONATH, Marc Y, EPPLER, Elisabeth, RIBAUX, Pascale, POSPISILIK, John A, MAOR-CAHN, Ranit, GUERIPEL, Xavier, ELLINGSGAARD, Helga, SCHNEIDER, Marten K. J, BIOLLAZ, Gregoire
Published in Diabetes (New York, N.Y.) (01.09.2007)
Published in Diabetes (New York, N.Y.) (01.09.2007)
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Journal Article
IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice
Westwell-Roper, Clara Y., Chehroudi, Cyrus A., Denroche, Heather C., Courtade, Jaques A., Ehses, Jan A., Verchere, C. Bruce
Published in Diabetologia (01.03.2015)
Published in Diabetologia (01.03.2015)
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Journal Article
Mechanisms of β-Cell Death in Type 2 Diabetes
DONATH, Marc Y, EHSES, Jan A, MAEDLER, Kathrin, SCHUMANN, Desiree M, ELLINGSGAARD, Helga, EPPLER, Elisabeth, REINECKE, Manfred
Published in Diabetes (New York, N.Y.) (01.12.2005)
Published in Diabetes (New York, N.Y.) (01.12.2005)
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Journal Article
Conference Proceeding
Interleukin-6 regulates pancreatic α-cell mass expansion
Ellingsgaard, Helga, Ehses, Jan A, Hammar, Eva B, Van Lommel, Leentje, Quintens, Roel, Martens, Geert, Kerr-Conte, Julie, Pattou, Francois, Berney, Thierry, Pipeleers, Daniel, Halban, Philippe A, Schuit, Frans C, Donath, Marc Y
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
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Journal Article
Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1
Nackiewicz, Dominika, Dan, Meixia, Speck, Madeleine, Chow, Samuel Z., Chen, Yi-Chun, Pospisilik, J. Andrew, Verchere, C. Bruce, Ehses, Jan A.
Published in iScience (24.01.2020)
Published in iScience (24.01.2020)
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Journal Article
Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats
POSPISILIK, J. Andrew, MARTIN, Jennifer, DOTY, Timothy, EHSES, Jan A, PAMIR, Nathalie, LYNN, Francis C, PITEAU, Shalea, DEMUTH, Hans-Ulrich, MCINTOSH, Christopher H. S, PEDERSON, Raymond A
Published in Diabetes (New York, N.Y.) (01.03.2003)
Published in Diabetes (New York, N.Y.) (01.03.2003)
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Journal Article
Macrophages, cytokines and beta-cell death in Type 2 diabetes
Ehses, Jan A, Böni-Schnetzler, Marianne, Faulenbach, Mirjam, Donath, Marc Y
Published in Biochemical Society transactions (01.06.2008)
Published in Biochemical Society transactions (01.06.2008)
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Journal Article
Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats
Calderari, Sophie, Irminger, Jean-Claude, Giroix, Marie-Hélène, Ehses, Jan A, Gangnerau, Marie-Noëlle, Coulaud, Josiane, Rickenbach, Katharina, Gauguier, Dominique, Halban, Philippe, Serradas, Patricia, Homo-Delarche, Françoise
Published in PloS one (26.02.2014)
Published in PloS one (26.02.2014)
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Journal Article
Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat
Lacraz, Grégory, Giroix, Marie-Hélène, Kassis, Nadim, Coulaud, Josiane, Galinier, Anne, Noll, Christophe, Cornut, Mélanie, Schmidlin, Fabien, Paul, Jean-Louis, Janel, Nathalie, Irminger, Jean-Claude, Kergoat, Micheline, Portha, Bernard, Donath, Marc Y, Ehses, Jan A, Homo-Delarche, Françoise
Published in PloS one (09.09.2009)
Published in PloS one (09.09.2009)
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Journal Article
Type 1, Type 1.5, and Type 2 Diabetes: NOD the Diabetes We Thought It Was
Donath, Marc Y., Ehses, Jan A.
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (15.08.2006)
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Journal Article