Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles
Eaton, John K., Furst, Laura, Ruberto, Richard A., Moosmayer, Dieter, Hilpmann, André, Ryan, Matthew J., Zimmermann, Katja, Cai, Luke L., Niehues, Michael, Badock, Volker, Kramm, Anneke, Chen, Sixun, Hillig, Roman C., Clemons, Paul A., Gradl, Stefan, Montagnon, Claire, Lazarski, Kiel E., Christian, Sven, Bajrami, Besnik, Neuhaus, Roland, Eheim, Ashley L., Viswanathan, Vasanthi S., Schreiber, Stuart L.
Published in Nature chemical biology (01.05.2020)
Published in Nature chemical biology (01.05.2020)
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Journal Article
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance
Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea
Published in Molecular cancer therapeutics (01.11.2018)
Published in Molecular cancer therapeutics (01.11.2018)
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Journal Article
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Steckel, Michael, Eheim, Ashley L, Haegebarth, Andrea, Stresemann, Carlo
Published in Journal of hematology and oncology (28.06.2019)
Published in Journal of hematology and oncology (28.06.2019)
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Journal Article
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target
Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo
Published in Cancers (14.01.2020)
Published in Cancers (14.01.2020)
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Journal Article
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
Christian, Sven, Merz, Claudia, Evans, Laura, Gradl, Stefan, Seidel, Henrik, Friberg, Anders, Eheim, Ashley, Lejeune, Pascale, Brzezinka, Krzysztof, Zimmermann, Katja, Ferrara, Steven, Meyer, Hanna, Lesche, Ralf, Stoeckigt, Detlef, Bauser, Marcus, Haegebarth, Andrea, Sykes, David B, Scadden, David T, Losman, Julie-Aurore, Janzer, Andreas
Published in Leukemia (01.10.2019)
Published in Leukemia (01.10.2019)
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Journal Article
Novel role of nuclear receptor rev‐erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury
Li, Ting, Eheim, Ashley L., Klein, Sabine, Uschner, Frank E., Smith, Amber C., Brandon‐Warner, Elizabeth, Ghosh, Sriparna, Bonkovsky, Herbert L., Trebicka, Jonel, Schrum, Laura W.
Published in Hepatology (Baltimore, Md.) (01.06.2014)
Published in Hepatology (Baltimore, Md.) (01.06.2014)
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Journal Article
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir, Jain, Esha, Lee, Dongjun, Meyer, Hanna, Pierce, Kerry A., Tolliday, Nicola J., Waller, Anna, Ferrara, Steven J., Eheim, Ashley L., Stoeckigt, Detlef, Maxcy, Katrina L., Cobert, Julien M., Bachand, Jacqueline, Szekely, Brian A., Mukherjee, Siddhartha, Sklar, Larry A., Kotz, Joanne D., Clish, Clary B., Sadreyev, Ruslan I., Clemons, Paul A., Janzer, Andreas, Schreiber, Stuart L., Scadden, David T.
Published in Cell (22.09.2016)
Published in Cell (22.09.2016)
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Journal Article
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target
Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás
Published in ACS chemical biology (18.08.2017)
Published in ACS chemical biology (18.08.2017)
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Journal Article
Lysophosphatidic acid receptor expression and function in human hepatocellular carcinoma
Sokolov, Eugene, PhD, Eheim, Ashley L., PhD, Ahrens, William A., MD, Walling, Tracy L., BS, Swet, Jacob H., MS, McMillan, Matthew T., BA, Simo, Kerri A., MD, Thompson, Kyle J., PhD, Sindram, David, MD, PhD, McKillop, Iain H., PhD
Published in The Journal of surgical research (01.03.2013)
Published in The Journal of surgical research (01.03.2013)
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Journal Article
Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Journal Article
Altered lysophosphatidic acid (LPA) receptor expression during hepatic regeneration in a mouse model of partial hepatectomy
Simo, Kerri A, Niemeyer, David J, Hanna, Erin M, Swet, Jacob H, Thompson, Kyle J, Sindram, David, Iannitti, David A, Eheim, Ashley L, Sokolov, Eugene, Zuckerman, Valentina, McKillop, Iain H
Published in HPB (Oxford, England) (01.06.2014)
Published in HPB (Oxford, England) (01.06.2014)
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Journal Article
Abstract 2077: Activity of DHODH inhibitor BAY2402234 in subcutaneous and intracranial models of SCLC
Kaulfuss, Stefan, Janzer, Andreas, Siemeister, Gerhard, Borowicz, Renan, Jaensch, Katrin, Gutberlet, Katrin, Schlenz, Ricarda, Triller, Andrea, Eheim, Ashley, Jeffers, Michael, Christian, Sven
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 3599: BAY 2402234: Preclinical evaluation of a novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of colorectal carcinomas
Merz, Claudia, Christian, Sven, Eheim, Ashley, Seidel, Henrik, Lesche, Ralf, Eversloh, Merlin Luetke, Meyer, Hanna, Ferrara, Steven, Bauser, Marcus, Haegebarth, Andrea, Gradl, Stefan, Janzer, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 3597: BAY 2402234: Preclinical evaluation of a novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of diffuse large B-cell lymphoma (DLBCL)
Eheim, Ashley, Christian, Sven, Meyer, Hanna, Stoeckigt, Detlef, Merz, Claudia, Zimmermann, Katja, Bauser, Marcus, Haegebarth, Andrea, Ferrara, Steven, Sykes, David B., Scadden, David T., Gradl, Stefan, Janzer, Andreas
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 2: Discovery of BAY 2402234 by phenotypic screening: A human Dihydroorotate Dehydrogenase (DHODH) inhibitor in clinical trials for the treatment of myeloid malignancies
Gradl, Stefan N., Mueller, Thomas, Ferrara, Steven, Sheikh, Sherif El, Janzer, Andreas, Zhou, Han-Jie, Friberg, Anders, Guenther, Judith, Schaefer, Martina, Stellfeld, Timo, Eis, Knut, Kroeber, Michael, Nguyen, Duy, Merz, Claudia, Niehues, Michael, Stoeckigt, Detlef, Christian, Sven, Zimmermann, Katja, Lejeune, Pascal, Bruening, Michael, Meyer, Hanna, Puetter, Vera, Scadden, David T., Sykes, David B., Seidel, Henrik, Eheim, Ashley, Michels, Martin, Haegebarth, Andrea, Bauser, Marcus
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target
Ellermann, Manuel, Giese, Anja, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Rahm, Fredrik, Viklund, Jenny, Andersson, Martin, Ginman, Tobias, Forsblom, Rickard, Lindström, Johan, Trésaugues, Lionel, Gorjanacz, Matyas
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1
Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract DDT02-04: BAY 2402234: A novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies
Janzer, Andreas, Gradl, Stefan, Christian, Sven, Zimmermann, Katja, Merz, Claudia, Meyer, Hanna, Stellfeld, Timo, Guenther, Judith, Stoeckigt, Detlef, Seidel, Henrik, Lejeune, Pascale, Bruening, Michael, Eheim, Ashley, Mueller, Thomas, Lesche, Ralf, Michels, Martin, Haegebarth, Andrea, Bauser, Marcus, Sheikh, Sherif El, Ferrara, Steven, Sykes, David, Scadden, David
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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