Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation
Egbertson, Melissa S, Cook, Jacquelynn J, Bednar, Bohumil, Prugh, John D, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Hartman, George D, Homnick, Carl F, Holahan, Marie A, Libby, Laura A, Lynch, Joseph J, Lynch, Robert J, Sitko, Gary R, Stranieri, Maria T, Vassallo, Laura M
Published in Journal of medicinal chemistry (01.07.1999)
Published in Journal of medicinal chemistry (01.07.1999)
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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors
Egbertson, Melissa S, Bednar, Bohumil, Askew, Ben C, Bednar, Rodney A, Brashear, Karen, Breslin, Michael J, Duggan, Mark E, Fisher, Thorsten E, Halczenko, Wasyl, Hutchinson, John H, Ihle, Nathan, Prugh, John D, Wai, John S, Gould, Robert J, Hartman, George D
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
Published in Bioorganic & medicinal chemistry letters (04.09.2000)
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Identification of Low Molecular Weight GP IIb/IIIa Antagonists That Bind Preferentially to Activated Platelets
Bednar, R A, Gaul, S L, Hamill, T G, Egbertson, M S, Shafer, J A, Hartman, G D, Gould, R J, Bednar, B
Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)
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Published in The Journal of pharmacology and experimental therapeutics (01.06.1998)
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Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes
Grobler, Jay A., Stillmock, Kara, Hu, Binghua, Witmer, Marc, Felock, Peter, Espeseth, Amy S., Wolfe, Abigail, Egbertson, Melissa, Bourgeois, Michele, Melamed, Jeffrey, Wai, John S., Young, Steve, Vacca, Joseph, Hazuda, Daria J.
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (14.05.2002)
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HIV-1 Integrase Inhibitors That Compete with the Target DNA Substrate Define a Unique Strand Transfer Conformation for Integrase
Espeseth, Amy S., Felock, Peter, Wolfe, Abigail, Witmer, Marc, Grobler, Jay, Anthony, Neville, Egbertson, Melissa, Melamed, Jeffrey Y., Young, Steve, Hamill, Terence, Cole, James L., Hazuda, Daria J.
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (10.10.2000)
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Nonpeptide glycoprotein IIb/IIIa inhibitors. 5. Antithrombotic effects of MK-0383
J J Lynch, Jr, J J Cook, G R Sitko, M A Holahan, D R Ramjit, M J Mellott, M T Stranieri, I I Stabilito, G Zhang, R J Lynch
Published in The Journal of pharmacology and experimental therapeutics (01.01.1995)
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Published in The Journal of pharmacology and experimental therapeutics (01.01.1995)
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Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation
Egbertson, M.S., Hartman, G.D., Gould, R.J., Bednar, B., Bednar, R.A., Cook, J.J., Gaul, S.L., Holahan, M.A., Libby, L.A., Lynch, J.J., Lynch, R.J., Sitko, G.R., Stranieri, M.T., Vassallo, L.M.
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
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DNA cross-linking by intermediates in the mitomycin activation cascade
Cera, Cinzia, Egbertson, Melissa, Teng, Sally P, Crothers, Donald M, Danishefsky, Samuel J
Published in Biochemistry (Easton) (27.06.1989)
Published in Biochemistry (Easton) (27.06.1989)
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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells
Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D
Published in Journal of medicinal chemistry (28.12.2000)
Published in Journal of medicinal chemistry (28.12.2000)
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Non-peptide glycoprotein IIb/IIIa inhibitors. 9. Centrally constrained alpha-sulfonamides are useful tools for exploring platelet receptor function
Egbertson, M.S., Bednar, B., Bednar, R.A., Hartman, G.D., Gould, R.J., Lynch, R.J., Vassallo, L.M., Young, S.D.
Published in Bioorganic & medicinal chemistry letters (18.06.1996)
Published in Bioorganic & medicinal chemistry letters (18.06.1996)
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Serendipitous discovery of a pH-dependant atropisomer bond rotation: Toward a write-protectable chiral molecular switch?
Welch, Christopher J., Biba, Mirlinda, Pye, Philip, Angelaud, Remy, Egbertson, Melissa
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.11.2008)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.11.2008)
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Journal Article
Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp
Egbertson, Melissa S, Chang, Charles T.-C, Duggan, Mark E, Gould, Robert J, Halczenko, Wasyl, Hartman, George D, Laswell, William L, Lynch, Joseph J, Lynch, Robert J
Published in Journal of medicinal chemistry (01.08.1994)
Published in Journal of medicinal chemistry (01.08.1994)
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Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells
Zhuang, Linghang, Wai, John S, Embrey, Mark W, Fisher, Thorsten E, Egbertson, Melissa S, Payne, Linda S, Guare, James P, Vacca, Joseph P, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Witmer, Marc V, Moyer, Gregory, Schleif, William A, Gabryelski, Lori J, Leonard, Yvonne M, Lynch, Joseph J, Michelson, Stuart R, Young, Steven D
Published in Journal of medicinal chemistry (13.02.2003)
Published in Journal of medicinal chemistry (13.02.2003)
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Journal Article
Tirofiban (Aggrastat®)
Cook, Jacquelynn J., Bednar, Bohumil, Lynch, Joseph J., Gould, Robert J., Egbertson, Melissa S., Halczenko, Wasyl, Duggan, Mark E., Hartman, George D., Lo, Man‐Wai, Murphy, Gail M., Deckelbaum, Lawrence I., Sax, Frederick L., Barr, Eliav
Published in Cardiovascular drug reviews (01.09.1999)
Published in Cardiovascular drug reviews (01.09.1999)
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Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine‐glycine‐aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets
Bednar, Bohumil, Cunningham, Michael E., McQueney, Patricia A., Egbertson, Melissa S., Askew, Benny C., Bednar, Rodney A., Hartman, George D., Gould, Robert J.
Published in Cytometry (New York, N.Y.) (01.05.1997)
Published in Cytometry (New York, N.Y.) (01.05.1997)
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Journal Article
Non-peptide fibrinogen receptor antagonists. 3. design and discovery of a centrally constrained inhibitor
Egbertson, M.S., Naylor, A.M., Hartman, G.D., Cook, J.J., Gould, R.J., Holahan, M.A., Lynch, J.J., Lynch, R.J., Stranieri, M.T., Vassallo, L.M.
Published in Bioorganic & medicinal chemistry letters (11.08.1994)
Published in Bioorganic & medicinal chemistry letters (11.08.1994)
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Journal Article
MK-0383, a potent intravenous inhibitor of platelet GP IIb/IIIa
Sax, F.L., Hartman, G.D., Egbertson, M., Lynch, J.J., Schaffer, L., Cook, J.J., Gould, R.J.
Published in Atherosclerosis (01.09.1994)
Published in Atherosclerosis (01.09.1994)
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