Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode
Down, Kenneth, Amour, Augustin, Anderson, Niall A, Barton, Nick, Campos, Sebastien, Cannons, Edward P, Clissold, Cole, Convery, Maire A, Coward, John J, Doyle, Kevin, Duempelfeld, Birgit, Edwards, Christopher D, Goldsmith, Michael D, Krause, Jana, Mallett, David N, McGonagle, Grant A, Patel, Vipulkumar K, Rowedder, James, Rowland, Paul, Sharpe, Andrew, Sriskantharajah, Srividya, Thomas, Daniel A, Thomson, Douglas W, Uddin, Sorif, Hamblin, J. Nicole, Hessel, Edith M
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Design and Development of a Macrocyclic Series Targeting Phosphoinositide 3‑Kinase δ
Spencer, Jonathan A, Baldwin, Ian R, Barton, Nick, Chung, Chun-Wa, Convery, Máire A, Edwards, Christopher D, Jamieson, Craig, Mallett, David N, Rowedder, James E, Rowland, Paul, Thomas, Daniel A, Hardy, Charlotte J
Published in ACS medicinal chemistry letters (09.07.2020)
Published in ACS medicinal chemistry letters (09.07.2020)
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Journal Article
p38α Mitogen-Activated Protein Kinase Inhibitors: Optimization of a Series of Biphenylamides to Give a Molecule Suitable for Clinical Progression
Aston, Nicola M, Bamborough, Paul, Buckton, Jacqueline B, Edwards, Christopher D, Holmes, Duncan S, Jones, Katherine L, Patel, Vipulkumar K, Smee, Penny A, Somers, Donald O, Vitulli, Giovanni, Walker, Ann L
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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Journal Article
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression
Aston, Nicola M, Bamborough, Paul, Buckton, Jacqueline B, Edwards, Christopher D, Holmes, Duncan S, Jones, Katherine L, Patel, Vipulkumar K, Smee, Penny A, Somers, Donald O, Vitulli, Giovanni, Walker, Ann L
Published in Journal of medicinal chemistry (22.10.2009)
Published in Journal of medicinal chemistry (22.10.2009)
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Journal Article
Liver Function, In-Hospital, and Post-Discharge Clinical Outcome in Patients With Acute Heart Failure—Results From the Relaxin for the Treatment of Patients With Acute Heart Failure Study
van Deursen, Vincent M., MD, PhD, Edwards, Christopher, MD, Cotter, Gad, MD, Davison, Beth A., PhD, Damman, Kevin, MD, PhD, Teerlink, John R., MD, Metra, Marco, MD, Felker, G. Michael, MD, Ponikowski, Piotr, MD, Unemori, Elaine, PhD, Severin, Thomas, MD, Voors, Adriaan A., MD, PhD
Published in Journal of cardiac failure (01.06.2014)
Published in Journal of cardiac failure (01.06.2014)
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Journal Article
Pinning a callout animation
Mahaffey, Terry J, Edwards, Christopher D, Konzelmann, Jaclyn E, Elias, Galen M
Year of Publication 25.12.2018
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Year of Publication 25.12.2018
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