Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Wiklander, Oscar P. B., Nordin, Joel Z., O'Loughlin, Aisling, Gustafsson, Ylva, Corso, Giulia, Mäger, Imre, Vader, Pieter, Lee, Yi, Sork, Helena, Seow, Yiqi, Heldring, Nina, Alvarez-Erviti, Lydia, Smith, CI Edvard, Le Blanc, Katarina, Macchiarini, Paolo, Jungebluth, Philipp, Wood, Matthew J. A., Andaloussi, Samir EL
Published in Journal of extracellular vesicles (01.01.2015)
Published in Journal of extracellular vesicles (01.01.2015)
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Journal Article
Diagnostics of primary immunodeficiency diseases: a sequencing capture approach
Moens, Lotte N, Falk-Sörqvist, Elin, Asplund, A Charlotta, Bernatowska, Ewa, Smith, C I Edvard, Nilsson, Mats
Published in PloS one (11.12.2014)
Published in PloS one (11.12.2014)
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Journal Article
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain
Mohamed, Abdalla J, Yu, Liang, Bäckesjö, Carl-Magnus, Vargas, Leonardo, Faryal, Rani, Aints, Alar, Christensson, Birger, Berglöf, Anna, Vihinen, Mauno, Nore, Beston F, Edvard Smith, C.I
Published in Immunological reviews (01.03.2009)
Published in Immunological reviews (01.03.2009)
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Journal Article
Therapeutic Oligonucleotides: State of the Art
Smith, C.I. Edvard, Zain, Rula
Published in Annual review of pharmacology and toxicology (06.01.2019)
Published in Annual review of pharmacology and toxicology (06.01.2019)
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Journal Article
Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents
Hande, Madhuri, Saher, Osama, Lundin, Karin E, Smith, C I Edvard, Zain, Rula, Lönnberg, Tuomas
Published in Molecules (Basel, Switzerland) (26.03.2019)
Published in Molecules (Basel, Switzerland) (26.03.2019)
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Journal Article
The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study
Xu, You, Gissberg, Olof, Pabon-Martinez, Y Vladimir, Wengel, Jesper, Lundin, Karin E, Smith, C I Edvard, Zain, Rula, Nilsson, Lennart, Villa, Alessandra
Published in PloS one (12.02.2019)
Published in PloS one (12.02.2019)
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Journal Article
Dual Phosphorylation of Btk by Akt/Protein Kinase B Provides Docking for 14-3-3ζ, Regulates Shuttling, and Attenuates both Tonic and Induced Signaling in B Cells
Mohammad, Dara K., Nore, Beston F., Hussain, Alamdar, Gustafsson, Manuela O., Mohamed, Abdalla J., Smith, C. I. Edvard
Published in Molecular and Cellular Biology (01.08.2013)
Published in Molecular and Cellular Biology (01.08.2013)
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Journal Article
Multi-level omics analysis in a murine model of dystrophin loss and therapeutic restoration
Roberts, Thomas C, Johansson, Henrik J, McClorey, Graham, Godfrey, Caroline, Blomberg, K Emelie M, Coursindel, Thibault, Gait, Michael J, Smith, C I Edvard, Lehtiö, Janne, El Andaloussi, Samir, Wood, Matthew J A
Published in Human molecular genetics (01.12.2015)
Published in Human molecular genetics (01.12.2015)
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Journal Article
A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo
Lehto, Taavi, Simonson, Oscar E, Mäger, Imre, Ezzat, Kariem, Sork, Helena, Copolovici, Dana-Maria, Viola, Joana R, Zaghloul, Eman M, Lundin, Per, Moreno, Pedro MD, Mäe, Maarja, Oskolkov, Nikita, Suhorutšenko, Julia, Smith, CI Edvard, Andaloussi, Samir EL
Published in Molecular therapy (01.08.2011)
Published in Molecular therapy (01.08.2011)
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Journal Article
Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting
Bergquist, Helen, Rocha, Cristina S J, Álvarez-Asencio, Rubén, Nguyen, Chi-Hung, Rutland, Mark W, Smith, C I Edvard, Good, Liam, Nielsen, Peter E, Zain, Rula
Published in PloS one (2016)
Published in PloS one (2016)
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Journal Article
Oligonucleotide Binding to Non-B-DNA in MYC
Umek, Tea, Sollander, Karin, Bergquist, Helen, Wengel, Jesper, Lundin, Karin E, Smith, C I Edvard, Zain, Rula
Published in Molecules (Basel, Switzerland) (2019)
Published in Molecules (Basel, Switzerland) (2019)
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Journal Article
Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects
Estupiñán, H Yesid, Berglöf, Anna, Zain, Rula, Smith, C I Edvard
Published in Frontiers in cell and developmental biology (11.03.2021)
Published in Frontiers in cell and developmental biology (11.03.2021)
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Journal Article
ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library
Gustafsson, Manuela O, Mohammad, Dara K, Ylösmäki, Erkko, Choi, Hyunseok, Shrestha, Subhash, Wang, Qing, Nore, Beston F, Saksela, Kalle, Smith, C I Edvard
Published in PloS one (2017)
Published in PloS one (2017)
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Journal Article
Single-stranded DNA oligonucleotides inhibit TLR3-mediated responses in human monocyte-derived dendritic cells and in vivo in cynomolgus macaques
Sköld, Annette E., Hasan, Maroof, Vargas, Leonardo, Saidi, Hela, Bosquet, Nathalie, Le Grand, Roger, Smith, C. I. Edvard, Spetz, Anna-Lena
Published in Blood (26.07.2012)
Published in Blood (26.07.2012)
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Journal Article
Expression Analysis in Multiple Muscle Groups and Serum Reveals Complexity in the MicroRNA Transcriptome of the mdx Mouse with Implications for Therapy
Roberts, Thomas C, Blomberg, K Emelie M, McClorey, Graham, Andaloussi, Samir EL, Godfrey, Caroline, Betts, Corinne, Coursindel, Thibault, Gait, Michael J, Edvard Smith, CI, Wood, Matthew JA
Published in Molecular therapy. Nucleic acids (2012)
Published in Molecular therapy. Nucleic acids (2012)
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Journal Article
Novel Orthogonally Hydrocarbon-Modified Cell-Penetrating Peptide Nanoparticles Mediate Efficient Delivery of Splice-Switching Antisense Oligonucleotides In Vitro and In Vivo
Bazaz, Safa, Lehto, Tõnis, Tops, Rahel, Gissberg, Olof, Gupta, Dhanu, Bestas, Burcu, Bost, Jeremy, Wiklander, Oscar P. B., Sork, Helena, Zaghloul, Eman M., Mamand, Doste R., Hällbrink, Mattias, Sillard, Rannar, Saher, Osama, Ezzat, Kariem, Smith, C. I. Edvard, Andaloussi, Samir EL, Lehto, Taavi
Published in Biomedicines (19.08.2021)
Published in Biomedicines (19.08.2021)
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Journal Article
Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers
Rastokina, Anastasia, Cebrián, Jorge, Mozafari, Negin, Mandel, Nicholas H, Smith, C I Edvard, Lopes, Massimo, Zain, Rula, Mirkin, Sergei M
Published in Nucleic acids research (08.09.2023)
Published in Nucleic acids research (08.09.2023)
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Journal Article
BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib
Estupiñán, H. Yesid, Wang, Qing, Berglöf, Anna, Schaafsma, Gerard C. P., Shi, Yuye, Zhou, Litao, Mohammad, Dara K., Yu, Liang, Vihinen, Mauno, Zain, Rula, Smith, C. I. Edvard
Published in Leukemia (01.05.2021)
Published in Leukemia (01.05.2021)
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Journal Article