ADME/PK as part of a rational approach to drug discovery
Eddershaw, Peter J, Beresford, Alan P, Bayliss, Martin K
Published in Drug Discovery Today (01.09.2000)
Published in Drug Discovery Today (01.09.2000)
Get full text
Book Review
Journal Article
Molecular modelling of human CYP2E1 by homology with the CYP102 haemoprotein domain: investigation of the interactions of substrates and inhibitors within the putative active site of the human CYP2E1 isoform
LEWIS, D. F. V, BIRD, M. G, DICKINS, M, LAKE, B. G, EDDERSHAW, P. J, TARBIT, M. H, GOLDFARB, P. S
Published in Xenobiotica (2000)
Published in Xenobiotica (2000)
Get full text
Journal Article
Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily
LEWIS, D. F. V., DICKINS, M., WEAVER, R. J., EDDERSHAW, P. J., GOLDFARB, P. S., TARBIT, M. H.
Published in Xenobiotica (01.03.1998)
Published in Xenobiotica (01.03.1998)
Get full text
Journal Article
Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4
LEWIS, D. F. V., LAKE, B. G., DICKINS, M., EDDERSHAW, P. J., TARBIT, M. H., GOLDFARB, P. S.
Published in Xenobiotica (1999)
Published in Xenobiotica (1999)
Get full text
Journal Article
Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102
Lewis, David F.V., Lake, Brian G., George, Stephen G., Dickins, Maurice, Eddershaw, Peter J., Tarbit, Michael H., Beresford, Alan P., Goldfarb, Peter S., Guengerich, F.Peter
Published in Toxicology (Amsterdam) (29.11.1999)
Published in Toxicology (Amsterdam) (29.11.1999)
Get full text
Journal Article
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors
Zhao, Yuan H., Le, Joelle, Abraham, Michael H., Hersey, Anne, Eddershaw, Peter J., Luscombe, Chris N., Boutina, Darko, Beck, Gordon, Sherborne, Brad, Cooper, Ian, Platts, James A.
Published in Journal of pharmaceutical sciences (01.06.2001)
Published in Journal of pharmaceutical sciences (01.06.2001)
Get full text
Journal Article
First principles investigation of singly reduced cytochrome P450
SEGALL, M. D., PAYNE, M. C., ELLIS, S. W., TUCKER, G. T., EDDERSHAW, P. J.
Published in Xenobiotica (01.06.1999)
Published in Xenobiotica (01.06.1999)
Get full text
Journal Article
The aliphatic oxidation of salmeterol to alpha-hydroxysalmeterol in human liver microsomes is catalyzed by CYP3A
Manchee, G R, Eddershaw, P J, Ranshaw, L E, Herriott, D, Park, G R, Bayliss, M K, Tarbit, M H
Published in Drug metabolism and disposition (01.05.1996)
Get more information
Published in Drug metabolism and disposition (01.05.1996)
Journal Article
Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite
Cannell, R J, Knaggs, A R, Dawson, M J, Manchee, G R, Eddershaw, P J, Waterhouse, I, Sutherland, D R, Bowers, G D, Sidebottom, P J
Published in Drug metabolism and disposition (01.07.1995)
Get more information
Published in Drug metabolism and disposition (01.07.1995)
Journal Article
Absorption and disposition of ranitidine hydrochloride in rat and dog
Eddershaw, P J, Chadwick, A P, Higton, D M, Fenwick, S H, Linacre, P, Jenner, W N, Bell, J A, Manchee, G R
Published in Xenobiotica (01.09.1996)
Published in Xenobiotica (01.09.1996)
Get more information
Journal Article
Characterization of glucuronic acid conjugates of a novel angiotensin receptor antagonist
Bowers, G D, Eddershaw, P J, Hughes, S Y, Manchee, G R, Oxford, J
Published in Rapid communications in mass spectrometry (01.02.1994)
Published in Rapid communications in mass spectrometry (01.02.1994)
Get more information
Journal Article
SB‐656104‐A, a novel selective 5‐HT7 receptor antagonist, modulates REM sleep in rats
Thomas, David R, Melotto, Sergio, Massagrande, Mario, Gribble, Andrew D, Jeffrey, Phillip, Stevens, Alexander J, Deeks, Nigel J, Eddershaw, Peter J, Fenwick, Susan H, Riley, Graham, Stean, Tania, Scott, Claire M, Hill, Matthew J, Middlemiss, Derek N, Hagan, Jim J, Price, Gary W, Forbes, Ian T
Published in British journal of pharmacology (01.06.2003)
Published in British journal of pharmacology (01.06.2003)
Get full text
Journal Article
SB-656104-A, a novel selective 5-HT sub(7) receptor antagonist, modulates REM sleep in rats
Thomas, DR, Melotto, S, Massagrande, M, Gribble, AD, Jeffrey, P, Stevens, A J, Deeks, N J, Eddershaw, P J, Fenwick, SH, Riley, G, Stean, T, Scott, C M, Hill, MJ, Middlemiss, D N
Published in British journal of pharmacology (01.06.2003)
Published in British journal of pharmacology (01.06.2003)
Get full text
Journal Article
Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b sub(5) binding site and comparisons with CYP2B1 and CYP2B4
Lewis, DFV, Lake, B G, Dickins, M, Eddershaw, P J, Tarbit, M H, Goldfarb, P S
Published in Xenobiotica (01.04.1999)
Get full text
Published in Xenobiotica (01.04.1999)
Journal Article