Discovery of Clinical Candidate 2‑(4-(2-((1H‑Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)‑N‑(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O‑Acyltransferase‑1 Inhibitor
Shibuya, Kimiyuki, Kawamine, Katsumi, Ozaki, Chiyoka, Ohgiya, Tadaaki, Edano, Toshiyuki, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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A method of direct measurement for the enzymatic determination of cholesteryl esters
Mizoguchi, Toshimi, Edano, Toshiyuki, Koshi, Tomoyuki
Published in Journal of lipid research (01.02.2004)
Published in Journal of lipid research (01.02.2004)
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Journal Article
Discovery of Clinical Candidate 2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetannide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor
Shibuya, Kimiyuki, Kawamine, Katsumi, Ozaki, Chiyoka, Ohgiya, Tadaaki, Edano, Toshiyuki, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors
Shibuya, Kimiyuki, Kawamine, Katsumi, Miura, Toru, Ozaki, Chiyoka, Edano, Toshiyuki, Mizuno, Ken, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko
Published in Bioorganic & medicinal chemistry (07.08.2018)
Published in Bioorganic & medicinal chemistry (07.08.2018)
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Protein C Activation by Recombinant Thrombomodulin in Plasma
EDANO, Toshiyuki, KOMINE, Noriko, YOSHIZAKI, Hideo, OHKUCHI, Masao
Published in Biological & pharmaceutical bulletin (01.02.1998)
Published in Biological & pharmaceutical bulletin (01.02.1998)
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Increased Anticoagulant Activity of Recombinant Thrombomodulin Modified with Glycosaminoglycan
EDANO, Toshiyuki, INOUE, Keisuke, YOSHIZAKI, Hideo, YAMAMOTO, Susumu, KOMINE, Noriko, TABUNOKI, Hiroko, SAWADA, Hironobu, KOSHI, Tomoyuki, MURAKAMI, Akira, WADA, Yasushi, OHKUCHI, Masao
Published in Biological & pharmaceutical bulletin (01.04.1998)
Published in Biological & pharmaceutical bulletin (01.04.1998)
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Importance of Sialic Acid in Recombinant Thrombomodulin in Terms of Pharmacokinetics and Separation of Desialyzed Glycoprotein
EDANO, Toshiyuki, KOSHI, Tomoyuki, YOSHIZAKI, Hideo, KUMAI, Natuyo, HABATA, Yuriko, KOIDE, Takashi, MIZOGUCHI, Toshimi, YAMAMOTO, Susumu, KIMATA, Hideki, OHKUCHI, Masao
Published in Biological & pharmaceutical bulletin (01.04.1998)
Published in Biological & pharmaceutical bulletin (01.04.1998)
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Inhibition of Endothelin (ET)-1- and ET-2-Induced Vasoconstriction by Anti-ET-1 Monoclonal Antibody
KOSHI, Tomoyuki, TORII, Takahiro, ARAI, Koichi, EDANO, Toshiyuki, HIRATA, Mitsuteru, OHKUCHI, Masao, OKABE, Tetsuro
Published in Chemical & pharmaceutical bulletin (1991)
Published in Chemical & pharmaceutical bulletin (1991)
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PROTEASE-RESISTANT SEB VARIANT AND VACCINE CONTAINING THE SAME
SAKATA, ATSUKO, SASAKI, TAKUMI, NAKASHIMA, TOSHIHIRO, OGUCHI, MASAO, TAKEMOTO, SUMIYO, NISHIHARA, TSUKASA, KOSHI, TOMOYUKI, EDANO, TOSHIYUKI
Year of Publication 17.03.2005
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Year of Publication 17.03.2005
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VASCULAR WALL-SELECTIVE ACAT INHIBITOR
SHIBUYA, KIMIYUKI, YOSHINAKA, YASUNOBU, KITAMURA, TAKAHIRO, KAWAMINE, KATSUMI, YAMADA, YOUICHI, MIURA, TORU, OOGIYA, TADAAKI, EDANO, TOSHIYUKI
Year of Publication 06.03.2003
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Year of Publication 06.03.2003
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SEB MODIFICATION AND PREVENTIVE/REMEDY FOR DISEASES WITH IMMUNE ABNORMALITY CONTIANING THE SAME
SAKATA, ATSUKO, SASAKI, TAKUMI, NAKASHIMA, TOSHIHIRO, OGUCHI, MASAO, KUWATA, SHIGEKI, KIMACHI, KAZUHIKO, NISHIHARA, TSUKASA, KOSHI, TOMOYUKI, EDANO, TOSHIYUKI
Year of Publication 14.10.2004
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Year of Publication 14.10.2004
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NOVEL CYCLIC DIAMINE COMPOUNDS AND MEDICINE CONTAINING THE SAME
SHIBUYA, KIMIYUKI, KAWAMINE, KATSUMI, SATO, YUKIHIRO, MIURA, TORU, OZAKI, CHIYOKA, EDANO, TOSHIYUKI, HIRATA, MITSUTERU
Year of Publication 03.12.1998
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Year of Publication 03.12.1998
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NOVEL ANILIDE COMPOUNDS AND DRUGS CONTAINING THE SAME
SHIBUYA, KIMIYUKI, KAWAMINE, KATSUMI, SATO, YUKIHIRO, OZAKI, CHIYOKA, EDANO, TOSHIYUKI, HIRATA, MITSUTERU
Year of Publication 01.10.1998
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Year of Publication 01.10.1998
Patent