Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes
Park, Eunyoung, Rawson, Shaun, Li, Kunhua, Kim, Byeong-Won, Ficarro, Scott B, Pino, Gonzalo Gonzalez-Del, Sharif, Humayun, Marto, Jarrod A, Jeon, Hyesung, Eck, Michael J
Published in Nature (London) (01.11.2019)
Published in Nature (London) (01.11.2019)
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EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors
Ercan, Dalia, Choi, Hwan Geun, Yun, Cai-Hong, Capelletti, Marzia, Xie, Ting, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A
Published in Clinical cancer research (01.09.2015)
Published in Clinical cancer research (01.09.2015)
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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
Jia, Yong, Yun, Cai-Hong, Park, Eunyoung, Ercan, Dalia, Manuia, Mari, Juarez, Jose, Xu, Chunxiao, Rhee, Kevin, Chen, Ting, Zhang, Haikuo, Palakurthi, Sangeetha, Jang, Jaebong, Lelais, Gerald, DiDonato, Michael, Bursulaya, Badry, Michellys, Pierre-Yves, Epple, Robert, Marsilje, Thomas H, McNeill, Matthew, Lu, Wenshuo, Harris, Jennifer, Bender, Steven, Wong, Kwok-Kin, Jänne, Pasi A, Eck, Michael J
Published in Nature (London) (02.06.2016)
Published in Nature (London) (02.06.2016)
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The FERM domain: organizing the structure and function of FAK
Frame, Margaret C, Eck, Michael J, Patel, Hitesh, Serrels, Bryan, Lietha, Daniel
Published in Nature reviews. Molecular cell biology (01.11.2010)
Published in Nature reviews. Molecular cell biology (01.11.2010)
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Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression
Cai, Weikang, Sakaguchi, Masaji, Kleinridders, Andre, Gonzalez-Del Pino, Gonzalo, Dreyfuss, Jonathan M, O'Neill, Brian T, Ramirez, Alfred K, Pan, Hui, Winnay, Jonathon N, Boucher, Jeremie, Eck, Michael J, Kahn, C Ronald
Published in Nature communications (27.03.2017)
Published in Nature communications (27.03.2017)
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Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors
Heppner, David E, Günther, Marcel, Wittlinger, Florian, Laufer, Stefan A, Eck, Michael J
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Yun, Cai-Hong, Mengwasser, Kristen E, Toms, Angela V, Woo, Michele S, Greulich, Heidi, Wong, Kwok-Kin, Meyerson, Matthew, Eck, Michael J
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2008)
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Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib
Tkacik, Emre, Li, Kunhua, Gonzalez-Del Pino, Gonzalo, Ha, Byung Hak, Vinals, Javier, Park, Eunyoung, Beyett, Tyler S., Eck, Michael J.
Published in The Journal of biological chemistry (01.05.2023)
Published in The Journal of biological chemistry (01.05.2023)
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Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors
Kosaka, Takayuki, Tanizaki, Junko, Paranal, Raymond M, Endoh, Hideki, Lydon, Christine, Capelletti, Marzia, Repellin, Claire E, Choi, Jihyun, Ogino, Atsuko, Calles, Antonio, Ercan, Dalia, Redig, Amanda J, Bahcall, Magda, Oxnard, Geoffrey R, Eck, Michael J, Jänne, Pasi A
Published in Cancer research (Chicago, Ill.) (15.05.2017)
Published in Cancer research (Chicago, Ill.) (15.05.2017)
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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
To, Ciric, Jang, Jaebong, Chen, Ting, Park, Eunyoung, Mushajiang, Mierzhati, De Clercq, Dries J H, Xu, Man, Wang, Stephen, Cameron, Michael D, Heppner, David E, Shin, Bo Hee, Gero, Thomas W, Yang, Annan, Dahlberg, Suzanne E, Wong, Kwok-Kin, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A
Published in Cancer discovery (01.07.2019)
Published in Cancer discovery (01.07.2019)
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Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
Park, Eunyoung, Kim, Nayoung, Ficarro, Scott B, Zhang, Yi, Lee, Byung Il, Cho, Ahye, Kim, Kihong, Park, Angela K J, Park, Woong-Yang, Murray, Bradley, Meyerson, Matthew, Beroukhim, Rameen, Marto, Jarrod A, Cho, Jeonghee, Eck, Michael J
Published in Nature structural & molecular biology (01.09.2015)
Published in Nature structural & molecular biology (01.09.2015)
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Cryo-EM structure of a RAS/RAF recruitment complex
Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J
Published in Nature communications (29.07.2023)
Published in Nature communications (29.07.2023)
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Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer
Yasuda, Hiroyuki, Park, Eunyoung, Yun, Cai-Hong, Sng, Natasha J, Lucena-Araujo, Antonio R, Yeo, Wee-Lee, Huberman, Mark S, Cohen, David W, Nakayama, Sohei, Ishioka, Kota, Yamaguchi, Norihiro, Hanna, Megan, Oxnard, Geoffrey R, Lathan, Christopher S, Moran, Teresa, Sequist, Lecia V, Chaft, Jamie E, Riely, Gregory J, Arcila, Maria E, Soo, Ross A, Meyerson, Matthew, Eck, Michael J, Kobayashi, Susumu S, Costa, Daniel B
Published in Science translational medicine (18.12.2013)
Published in Science translational medicine (18.12.2013)
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Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex
Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
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