Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target
Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo
Published in Cancers (14.01.2020)
Published in Cancers (14.01.2020)
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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models
Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik
Published in Molecular cancer therapeutics (01.01.2020)
Published in Molecular cancer therapeutics (01.01.2020)
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Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard
Published in The Journal of biological chemistry (28.03.2014)
Published in The Journal of biological chemistry (28.03.2014)
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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
Lücking, Ulrich, Wortmann, Lars, Wengner, Antje M, Lefranc, Julien, Lienau, Philip, Briem, Hans, Siemeister, Gerhard, Bömer, Ulf, Denner, Karsten, Schäfer, Martina, Koppitz, Marcus, Eis, Knut, Bartels, Florian, Bader, Benjamin, Bone, Wilhelm, Moosmayer, Dieter, Holton, Simon J, Eberspächer, Uwe, Grudzinska-Goebel, Joanna, Schatz, Christoph, Deeg, Gesa, Mumberg, Dominik, von Nussbaum, Franz
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5
Nguyen, Duy, Lemos, Clara, Wortmann, Lars, Eis, Knut, Holton, Simon J, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Weiske, Joerg, Lechner, Christian, Prechtl, Stefan, Suelzle, Detlev, Siegel, Franziska, Prinz, Florian, Lesche, Ralf, Nicke, Barbara, Nowak-Reppel, Katrin, Himmel, Herbert, Mumberg, Dominik, von Nussbaum, Franz, Nising, Carl F, Bauser, Marcus, Haegebarth, Andrea
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Bothe, Ulrich, Günther, Judith, Nubbemeyer, Reinhard, Siebeneicher, Holger, Ring, Sven, Bömer, Ulf, Peters, Michaele, Rausch, Alexandra, Denner, Karsten, Himmel, Herbert, Sutter, Andreas, Terebesi, Ildiko, Lange, Martin, Wengner, Antje M., Guimond, Nicolas, Thaler, Tobias, Platzek, Johannes, Eberspächer, Uwe, Schäfer, Martina, Steuber, Holger, Zollner, Thomas M., Steinmeyer, Andreas, Schmidt, Nicole
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Mouse androgen-dependent epididymal glycoprotein CRISP-1 (DE/AEG): isolation, biochemical characterization, and expression in recombinant form
Eberspaecher, U, Roosterman, D, Krätzschmar, J, Haendler, B, Habenicht, U F, Becker, A, Quensel, C, Petri, T, Schleuning, W D, Donner, P
Published in Molecular reproduction and development (01.10.1995)
Published in Molecular reproduction and development (01.10.1995)
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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy
Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette
Published in Bioconjugate chemistry (15.06.2022)
Published in Bioconjugate chemistry (15.06.2022)
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Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase
Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies
Berger, Markus, Wortmann, Lars, Buchgraber, Philipp, Lücking, Ulrich, Zitzmann-Kolbe, Sabine, Wengner, Antje M, Bader, Benjamin, Bömer, Ulf, Briem, Hans, Eis, Knut, Rehwinkel, Hartmut, Bartels, Florian, Moosmayer, Dieter, Eberspächer, Uwe, Lienau, Philip, Hammer, Stefanie, Schatz, Christoph A, Wang, Qiuwen, Wang, Qi, Mumberg, Dominik, Nising, Carl F, Siemeister, Gerhard
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Abstract 1722: Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1
Leder, Gabriele, Carretero, Rafael, Mowat, Jeffrey, Berndt, Sandra, Neuhaus, Roland, Font, Nuria Aiguabella, Boemer, Ulf, von Ahsen, Oliver, Eberspaecher, Uwe, Guenther, Judith, Grees, Mareike, Link, Corinna, Nicke, Barbara, Baumann, Daniel, Schaefer, Martina, Oezcan-Wahlbrink, Mine, Werbeck, Nicolas D., Hartung, Ingo, Kreft, Bertolt, Offringa, Rienk
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 1470: Preclinical activity of the first reversible, potent and selective inhibitor of EGFR exon 20 insertions
Siegel, Franziska, Siegel, Stephan, Graham, Keith, Kaplan, Bethany, Petersen, Kirstin, Boemer, Ulf, Eberspaecher, Uwe, Korr, Daniel, Moenning, Ursula, Suelzle, Detlev, Schroeder, Jens, Prinz, Florian, Zitzmann-Kolbe, Sabine, Karsli-Uzunbas, Gizem, Lewis, Timothy, Hermsen, Mario, Cherniack, Andrew, von Nussbaum, Franz, Eis, Knut, Meyerson, Matthew, Greulich, Heidi
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis
Santamaria, Anna, Neef, Rüdiger, Eberspächer, Uwe, Eis, Knut, Husemann, Manfred, Mumberg, Dominik, Prechtl, Stefan, Schulze, Volker, Siemeister, Gerhard, Wortmann, Lars, Barr, Francis A, Nigg, Erich A
Published in Molecular biology of the cell (01.10.2007)
Published in Molecular biology of the cell (01.10.2007)
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Abstract 4989: 3D spheroid screen yields SCD1 pathway inhibitors for the treatment of cancer
Gruenewald, Sylvia, Sperl, Carolyn, Steigemann, Patrick, Walter, Alexander, Zacharias, Sylvia, Eberspaecher, Uwe, Neuhaus, Roland, Zorn, Ludwig, Schwede, Wolfgang, Thede, Kai, Christian, Sven
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A
Friberg, Anders, Rehwinkel, Hartmut, Nguyen, Duy, Pütter, Vera, Quanz, Maria, Weiske, Jörg, Eberspächer, Uwe, Heisler, Iring, Langer, Gernot
Published in ACS omega (09.06.2020)
Published in ACS omega (09.06.2020)
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2--4--17- 2-MORPHOLIN-4-YL-17-NAPHTHYRIDINES
BADER BENJAMIN, LIENAU PHILIP, MOOSMAYER DIETER, EBERSPAECHER UWE, GRUDZINSKA GOEBEL JOANNA, KOPPITZ MARCUS, VON NUSSBAUM FRANZ, SIEMEISTER GERHARD, EIS KNUT, WORTMANN LARS, BONE WILHELM, WENGNER ANTJE MARGRET, LEFRANC JULIEN, BRIEM HANS, LUECKING ULRICH, SCHICK HANS
Year of Publication 19.11.2020
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Year of Publication 19.11.2020
Patent
Identifying protein construct variants with increased crystallization propensity––A case study
Malawski, Guido A., Hillig, Roman C., Monteclaro, Felipe, Eberspaecher, Uwe, Schmitz, Arndt A.P., Crusius, Kerstin, Huber, Martina, Egner, Ursula, Donner, Peter, Müller‐Tiemann, Beate
Published in Protein science (01.12.2006)
Published in Protein science (01.12.2006)
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Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin
Bandeiras, Tiago M., Hillig, Roman Christian, Matias, Pedro M., Eberspaecher, Uwe, Fanghänel, Jörg, Thomaz, Mónica, Miranda, Sandra, Crusius, Kerstin, Pütter, Vera, Amstutz, Patrick, Gulotti-Georgieva, Maya, Binz, H. Kaspar, Holz, Caterina, Schmitz, Arndt A. P., Lang, Christine, Donner, Peter, Egner, Ursula, Carrondo, Maria A., Müller-Tiemann, Beate
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2008)
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2008)
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