Structural studies of viperin, an antiviral radical SAM enzyme
Fenwick, Michael K., Li, Yue, Cresswell, Peter, Modis, Yorgo, Ealick, Steven E.
Published in Proceedings of the National Academy of Sciences - PNAS (27.06.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (27.06.2017)
Get full text
Journal Article
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase
CHATTERJEE, Abhishek, DINUKA ABEYDEERA, N, BALE, Shridhar, PAI, Pei-Jing, DORRESTEIN, Pieter C, RUSSELL, David H, EALICK, Steven E, BEGLEY, Tadhg P
Published in Nature (London) (27.10.2011)
Published in Nature (London) (27.10.2011)
Get full text
Journal Article
Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis
Dong, Min, Kathiresan, Venkatesan, Fenwick, Michael K, Torelli, Andrew T, Zhang, Yang, Caranto, Jonathan D, Dzikovski, Boris, Sharma, Ajay, Lancaster, Kyle M, Freed, Jack H, Ealick, Steven E, Hoffman, Brian M, Lin, Hening
Published in Science (American Association for the Advancement of Science) (16.03.2018)
Published in Science (American Association for the Advancement of Science) (16.03.2018)
Get full text
Journal Article
Pyridoxal phosphate: Biosynthesis and catabolism
Mukherjee, Tathagata, Hanes, Jeremiah, Tews, Ivo, Ealick, Steven E., Begley, Tadhg P.
Published in Biochimica et biophysica acta (01.11.2011)
Published in Biochimica et biophysica acta (01.11.2011)
Get full text
Journal Article
Thiamin biosynthesis: still yielding fascinating biological chemistry
Begley, Tadhg P, Ealick, Steven E, McLafferty, Fred W
Published in Biochemical Society transactions (01.06.2012)
Published in Biochemical Society transactions (01.06.2012)
Get more information
Journal Article
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
Begley, Tadhg P, Booker, Squire J, Lee, Michael, Chatterjee, Abhishek, Li, Yue, Ealick, Steven E, Zhang, Yang, Grove, Tyler L, Krebs, Carsten
Published in Nature chemical biology (01.12.2008)
Published in Nature chemical biology (01.12.2008)
Get full text
Journal Article
Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase
Fenwick, Michael K, Mehta, Angad P, Zhang, Yang, Abdelwahed, Sameh H, Begley, Tadhg P, Ealick, Steven E
Published in Nature communications (27.03.2015)
Published in Nature communications (27.03.2015)
Get full text
Journal Article
Different polyamine pathways from bacteria have replaced eukaryotic spermidine biosynthesis in ciliates Tetrahymena thermophila and Paramecium tetaurelia
Li, Bin, Kim, Sok Ho, Zhang, Yang, Hanfrey, Colin C., Elliott, Katherine A., Ealick, Steven E., Michael, Anthony J.
Published in Molecular microbiology (01.09.2015)
Published in Molecular microbiology (01.09.2015)
Get full text
Journal Article
Thiamin Pyrimidine Biosynthesis in Candida albicans: A Remarkable Reaction between Histidine and Pyridoxal Phosphate
Lai, Rung-Yi, Huang, Siyu, Fenwick, Michael K, Hazra, Amrita, Zhang, Yang, Rajashankar, Kanagalaghatta, Philmus, Benjamin, Kinsland, Cynthia, Sanders, Jennie Mansell, Ealick, Steven E, Begley, Tadhg P
Published in Journal of the American Chemical Society (06.06.2012)
Published in Journal of the American Chemical Society (06.06.2012)
Get full text
Journal Article
Crystal Structure and Mechanism of Tryptophan 2,3-Dioxygenase, a Heme Enzyme Involved in Tryptophan Catabolism and in Quinolinate Biosynthesis
Zhang, Yang, Kang, Seong A, Mukherjee, Tathagata, Bale, Shridhar, Crane, Brian R, Begley, Tadhg P, Ealick, Steven E
Published in Biochemistry (Easton) (09.01.2007)
Published in Biochemistry (Easton) (09.01.2007)
Get full text
Journal Article
Catalysis of a Flavoenzyme-Mediated Amide Hydrolysis
Mukherjee, Tathagata, Zhang, Yang, Abdelwahed, Sameh, Ealick, Steven E, Begley, Tadhg P
Published in Journal of the American Chemical Society (28.04.2010)
Published in Journal of the American Chemical Society (28.04.2010)
Get full text
Journal Article
Ethenoguanines undergo glycosylation by nucleoside 2'-deoxyribosyltransferases at non-natural sites
Ye, Wenjie, Paul, Debamita, Gao, Lina, Seckute, Jolita, Sangaiah, Ramiah, Jayaraj, Karupiah, Zhang, Zhenfa, Kaminski, P Alexandre, Ealick, Steven E, Gold, Avram, Ball, Louise M
Published in PloS one (18.12.2014)
Published in PloS one (18.12.2014)
Get full text
Journal Article
Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from Mesorhizobium loti MAFF303099 and Its Mechanistic Implications
McCulloch, Kathryn M, Mukherjee, Tathagata, Begley, Tadhg P, Ealick, Steven E
Published in Biochemistry (Easton) (19.05.2009)
Published in Biochemistry (Easton) (19.05.2009)
Get full text
Journal Article
Structure of Oxalate Decarboxylase from Bacillus subtilis at 1.75 Å Resolution
Anand, Ruchi, Dorrestein, Pieter C, Kinsland, Cynthia, Begley, Tadhg P, Ealick, Steven E
Published in Biochemistry (Easton) (18.06.2002)
Published in Biochemistry (Easton) (18.06.2002)
Get full text
Journal Article
Structural biology of enzymes of the thiamin biosynthesis pathway
Settembre, Ethan, Begley, Tadhg P, Ealick, Steven E
Published in Current opinion in structural biology (01.12.2003)
Published in Current opinion in structural biology (01.12.2003)
Get full text
Journal Article
O-Phospho-l-serine and the Thiocarboxylated Sulfur Carrier Protein CysO-COSH Are Substrates for CysM, a Cysteine Synthase from Mycobacterium tuberculosis
O’Leary, Seán E, Jurgenson, Christopher T, Ealick, Steven E, Begley, Tadhg P
Published in Biochemistry (Easton) (04.11.2008)
Published in Biochemistry (Easton) (04.11.2008)
Get full text
Journal Article