Discovery of hydroxy pyrimidine Factor IXa inhibitors
Jayne, Charles L., Andreani, Teresa, Chan, Tin-Yau, Chelliah, Mariappan V., Clasby, Martin C., Dwyer, Michael, Eagen, Keith A., Fried, Steve, Greenlee, William J., Guo, Zhuyan, Hawes, Brian, Hruza, Alan, Ingram, Richard, Keertikar, Kartik M., Neelamkavil, Santhosh, Reichert, Paul, Xia, Yan, Chackalamannil, Samuel
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
Published in Bioorganic & medicinal chemistry letters (01.08.2020)
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Journal Article
Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists
Cox, Jason M, Chu, Hong D, Chelliah, Mariappan V, Debenham, John S, Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A, Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M, Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R, Crespo, Alejandro, Madeira, Maria, Leung, Dennis H, Alleyne, Candice, Ogawa, Aimie M, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E, Ujjainwalla, Feroze, Tata, James R, Sinz, Christopher J
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Journal Article
Metabolism-Based Identification of a Potent Thrombin Receptor Antagonist
Clasby, Martin C, Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William, Kao, Grace, Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Smith-Torhan, April, Alton, Kevin, Bryant, Matthew, Hsieh, Yunsheng, Lau, Janice, Palamanda, Jairam
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Journal Article
Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Darío, Eagen, Keith, Greenlee, William J., Lin, Yan, Tagat, Jayaram R., Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Hsieh, Yunsheng, McPhail, Andrew T.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
Structure–Activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors
Chou, Yuo-Ling, Davey, David D, Eagen, Keith A, Griedel, Brian D, Karanjawala, Rushad, Phillips, Gary B, Sacchi, Karna L, Shaw, Kenneth J, Wu, Shung C, Lentz, Dao, Liang, Amy M, Trinh, Lan, Morrissey, Michael M, Kochanny, Monica J
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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Journal Article
Design, Synthesis, and Activity of 2,6-Diphenoxypyridine-Derived Factor Xa Inhibitors
Phillips, Gary, Davey, David D, Eagen, Keith A, Koovakkat, Sunil K, Liang, Amy, Ng, Howard P, Pinkerton, Michael, Trinh, Lan, Whitlow, Marc, Beatty, Alicia M, Morrissey, Michael M
Published in Journal of medicinal chemistry (20.05.1999)
Published in Journal of medicinal chemistry (20.05.1999)
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Journal Article
Design, Synthesis, and Activity of a Novel Series of Factor Xa Inhibitors: Optimization of Arylamidine Groups
Phillips, Gary, Guilford, William J, Buckman, Brad O, Davey, David D, Eagen, Keith A, Koovakkat, Sunil, Liang, Amy, McCarrick, Meg, Mohan, Raju, Ng, Howard P, Pinkerton, Michael, Subramanyam, Babu, Ho, Elena, Trinh, Lan, Whitlow, Marc, Wu, Shung, Xu, Wei, Morrissey, Michael M
Published in Journal of medicinal chemistry (06.06.2002)
Published in Journal of medicinal chemistry (06.06.2002)
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Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa
Phillips, Gary B, Buckman, Brad O, Davey, David D, Eagen, Keith A, Guilford, William J, Hinchman, Josephine, Ho, Elena, Koovakkat, Sunil, Liang, Amy, Light, David R, Mohan, Raju, Ng, Howard P, Post, Joseph M, Shaw, Kenneth J, Smith, Dave, Subramanyam, Babu, Sullivan, Mark E, Trinh, Lan, Vergona, Ron, Walters, Janette, White, Kathy, Whitlow, Marc, Wu, Shung, Xu, Wei, Morrissey, Michael M
Published in Journal of medicinal chemistry (10.09.1998)
Published in Journal of medicinal chemistry (10.09.1998)
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Journal Article
Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines
Ng, Howard P., Buckman, Brad O., Eagen, Keith A., Guilford, William J., Kochanny, Monica J., Mohan, Raju, Shaw, Kenneth J., Wu, Shung C., Lentz, Dao, Liang, Amy, Trinh, Lan, Ho, Elena, Smith, David, Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Sullivan, Mark E., Morrissey, Michael M., Phillips, Gary B.
Published in Bioorganic & medicinal chemistry (01.03.2002)
Published in Bioorganic & medicinal chemistry (01.03.2002)
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Journal Article
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor
Neelamkavil, Santhosh F, Agrawal, Sony, Bara, Thomas, Bennett, Chad, Bhat, Sathesh, Biswas, Dipshikha, Brockunier, Linda, Buist, Nicole, Burnette, Duane, Cartwright, Mark, Chackalamannil, Samuel, Chase, Robert, Chelliah, Mariappan, Chen, Austin, Clasby, Martin, Colandrea, Vincent J, Davies, Ian W, Eagen, Keith, Guo, Zhuyan, Han, Yongxin, Howe, John, Jayne, Charles, Josien, Hubert, Kargman, Stacia, Marcantonio, Karen, Miao, Shouwu, Miller, Randy, Nolting, Andrew, Pinto, Patrick, Rajagopalan, Murali, Ruck, Rebecca T, Shah, Unmesh, Soriano, Aileen, Sperbeck, Donald, Velazquez, Francisco, Wu, Jin, Xia, Yan, Venkatraman, Srikanth
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Journal Article
Himbacine-Derived Thrombin Receptor Antagonists: C-7-Spirocyclic Analogues of Vorapaxar
Chelliah, Mariappan V., Eagen, Keith, Guo, Zhuyan, Chackalamannil, Samuel, Xia, Yan, Tsai, Hsingan, Greenlee, William J., Ahn, Ho-Sam, Kurowski, Stan, Boykow, George, Hsieh, Yunsheng, Chintala, Madhu
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
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Journal Article
Himbacine-Derived Thrombin Receptor Antagonists: C7‑Spirocyclic Analogues of Vorapaxar
Chelliah, Mariappan V, Eagen, Keith, Guo, Zhuyan, Chackalamannil, Samuel, Xia, Yan, Tsai, Hsingan, Greenlee, William J, Ahn, Ho-Sam, Kurowski, Stan, Boykow, George, Hsieh, Yunsheng, Chintala, Madhu
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
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Journal Article
Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors
Davey, David D, Adler, Marc, Arnaiz, Damian, Eagen, Keith, Erickson, Shawn, Guilford, William, Kenrick, Margaret, Morrissey, Michael M, Ohlmeyer, Mike, Pan, Gonghua, Paradkar, Vidyadhar M, Parkinson, John, Polokoff, Mark, Saionz, Kurt, Santos, Cecile, Subramanyam, Babu, Vergona, Ron, Wei, Robert G, Whitlow, Marc, Ye, Bin, Zhao, Zuchun (Spring), Devlin, James J, Phillips, Gary
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
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Journal Article
Discovery of nor-seco himbacine analogs as thrombin receptor antagonists
Chelliah, Mariappan V., Chackalamannil, Samuel, Xia, Yan, Eagen, Keith, Greenlee, William J., Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Hsieh, Yunsheng, Bryant, Matthew, Chan, Tze-Ming, Chintala, Madhu
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Journal Article
Heterotricyclic Himbacine Analogs as Potent, Orally Active Thrombin Receptor (Protease Activated Receptor-1) Antagonists
Chelliah, Mariappan V, Chackalamannil, Samuel, Xia, Yan, Eagen, Keith, Clasby, Martin C, Gao, Xiaobang, Greenlee, William, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Hsieh, Yunsheng, Bryant, Matthew, Palamanda, Jairam, Chan, Tze-Ming, Hesk, David, Chintala, Madhu
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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Journal Article
Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry
McMillan, Kirk, Adler, Marc, Auld, Douglas S., Baldwin, John J., Blasko, Eric, Browne, Leslie J., Chelsky, Daniel, Davey, David, Dolle, Ronald E., Eagen, Keith A., Erickson, Shawn, Feldman, Richard I., Glaser, Charles B., Mallari, Cornell, Morrissey, Michael M., Michael H. J. Ohlmeyer, Pan, Gonghua, Parkinson, John F., Phillips, Gary B., Polokoff, Mark A., Sigal, Nolan H., Vergona, Ronald, Whitlow, Marc, Young, Tish A., Devlin, James J.
Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2000)
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Journal Article
SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS
PLOTKIN MICHAEL A, CHU HONG DONG, COX JASON M, DEBENHAM JOHN S, SHAH UNMESH, LONDON CLARE, SINZ CHRISTOPHER JOSEPH, CHELLIAH MARIAPPAN, SUN ZHONGXIANG, VACCARO HENRY M, EAGEN KEITH, VENKATRAMAN SKIKANTH, LAN PING
Year of Publication 17.06.2015
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Year of Publication 17.06.2015
Patent
Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring
Xia, Yan, Chackalamannil, Samuel, Clasby, Martin, Doller, Darío, Eagen, Keith, Greenlee, William J., Tsai, Hsingan, Agans-Fantuzzi, Jacqueline, Ahn, Ho-Sam, Boykow, George C., Hsieh, Yunsheng, Lunn, Charles A., Chintala, Madhu
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists
Clasby, Martin C., Chackalamannil, Samuel, Czarniecki, Michael, Doller, Dario, Eagen, Keith, Greenlee, William J., Lin, Yan, Tsai, Hsingan, Xia, Yan, Ahn, Ho-Sam, Agans-Fantuzzi, Jacqueline, Boykow, George, Chintala, Madhu, Foster, Carolyn, Bryant, Matthew, Lau, Janice
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Journal Article