Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
Sanderson, Philip E. J, Lyle, Terry A, Cutrona, Kellie J, Dyer, Dona L, Dorsey, Bruce D, McDonough, Colleen M, Naylor-Olsen, Adel M, Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J, Cooper, Carolyn M, Gardell, Stephen J, Hare, Timothy R, Krueger, Julie A, Lewis, S. Dale, Lin, Jiunn H, Lucas, Bobby J, Lyle, Elizabeth A, Lynch, Joseph J, Stranieri, Maria T, Vastag, Kari, Yan, Youwei, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Journal Article
Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the ‘Distal binding pocket’
Sanderson, Philip E.J., Cutrona, Kellie J., Dyer, Dona L., Krueger, Julie A., Kuo, Lawrence C., Lewis, S.Dale, Lucas, Bobby J., Yan, Youwei
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
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Antithrombotic Efficacy of Thrombin Inhibitor L-374,087: Intravenous Activity in a Primate Model of Venous Thrombus Extension and Oral Activity in a Canine Model of Primary Venous and Coronary Artery Thrombosis
Cook, J J, Gardell, S J, Holahan, M A, Sitko, G R, Stump, G L, Wallace, A A, Gilberto, D B, Hare, T R, Krueger, J A, Dyer, D L, Sanderson, P E, Vacca, J P, Shafer, J A, Lynch, Jr, J J
Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.04.1999)
Journal Article
L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor
Sanderson, Philip E.J., Cutrona, Kellie J., Dorsey, Bruce D., Dyer, Dona L., McDonough, Colleen M., Naylor-Olsen, Adel M., Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J., Gardell, Stephen J., Krueger, Julie A., Lewis, S.Dale, Lin, Jiunn H., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Stranieri, Maria T., Vastag, Kari, Shafer, Jules A., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
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Journal Article
L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor
Sanderson, Philip E.J., Dyer, Dona L., Naylor-Olsen, Adel M., Vacca, Joseph P., Gardell, Steven J., Dale Lewis, S., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Mulichak, Anne M.
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
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Journal Article
Small, Low Nanomolar, Noncovalent Thrombin Inhibitors Lacking a Group to Fill the "Distal Binding Pocket"
Sanderson, Philip E. J., Cutrona, Kellie J., Dyer, Dona L., Krueger, Julie A., Kuo, Lawrence C., Lewis, S. Dale, Lucas, Bobby J., Yan, Youwei
Published in ChemInform (06.05.2003)
Published in ChemInform (06.05.2003)
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Journal Article
Pyridinone-thrombin inhibitors
JOSEPH P. VACCA, PHILIP E SANDERSON, ADEL M. NAYLOR-OLSEN, BRUCE D DORSEY, DONA L. DYER, RICHARD C. A. ISAACS, MARK E. FRALEY
Year of Publication 01.04.1999
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Year of Publication 01.04.1999
Patent
PYRIDINONE-THROMBIN INHIBITORS
DYER, DONA, L, VACCA, JOSEPH, P, NAYLOR-OLSEN, ADEL, M, FRALEY, MARK, E, ISAACS, RICHARD, C., A, DORSEY, BRUCE, D, SANDERSON, PHILIP, E
Year of Publication 03.02.1999
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Year of Publication 03.02.1999
Patent
Pyridinone thrombin inhibitors
SANDERSON; PHILIP E, FRALEY; MARK E, DORSEY; BRUCE D, DYER; DONA L, ISAACS; RICHARD C. A, NAYLOR-OLSEN; ADEL M, VACCA; JOSEPH P
Year of Publication 28.04.1998
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Year of Publication 28.04.1998
Patent
PYRIDINONE-THROMBIN INHIBITORS
DYER, DONA, L, VACCA, JOSEPH, P, NAYLOR-OLSEN, ADEL, M, FRALEY, MARK, E, ISAACS, RICHARD, C., A, DORSEY, BRUCE, D, SANDERSON, PHILIP, E
Year of Publication 15.04.1998
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Year of Publication 15.04.1998
Patent
Pyridinone thrombin inhibitors
SANDERSON; PHILIP E, FRALEY; MARK E, DORSEY; BRUCE D, DYER; DONA L, ISAACS; RICHARD C. A, NAYLOR-OLSEN; ADEL M, VACCA; JOSEPH P
Year of Publication 16.09.1997
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Year of Publication 16.09.1997
Patent
Pyridinone-thrombin inhibitors
JOSEPH P. VACCA, PHILIP E SANDERSON, ADEL M. NAYLOR-OLSEN, BRUCE D DORSEY, DONA L. DYER, RICHARD C. A. ISAACS, MARK E. FRALEY
Year of Publication 30.01.1997
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Year of Publication 30.01.1997
Patent
PYRIDINONE-THROMBIN INHIBITORS
DYER, DONA, L, VACCA, JOSEPH, P, NAYLOR-OLSEN, ADEL, M, FRALEY, MARK, E, ISAACS, RICHARD, C., A, DORSEY, BRUCE, D, SANDERSON, PHILIP, E
Year of Publication 16.01.1997
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Year of Publication 16.01.1997
Patent
PYRIDINONE-THROMBIN INHIBITORS
VACCA, JOSEPH P, DYER, DONA L, ISSACS, RICHARD C.A, FRALEY, MARK E, DORSEY, BRUCE D, NAYLOR-OLSEN, ADEL M, SANDERSON, PHILIP E
Year of Publication 16.01.1997
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Year of Publication 16.01.1997
Patent