Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma
Pruss, Maximilian, Dwucet, Annika, Tanriover, Mine, Hlavac, Michal, Kast, Richard Eric, Debatin, Klaus-Michael, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Siegelin, Markus David, Westhoff, Mike-Andrew, Karpel-Massler, Georg
Published in British journal of cancer (01.04.2020)
Published in British journal of cancer (01.04.2020)
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Journal Article
Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification
Karpel-Massler, Georg, Kast, Richard E., Siegelin, Markus D., Dwucet, Annika, Schneider, Elisabeth, Westhoff, Mike-Andrew, Wirtz, Christian Rainer, Chen, Xiao Yun, Halatsch, Marc-Eric, Bolm, Carsten
Published in Neurochemical research (01.12.2017)
Published in Neurochemical research (01.12.2017)
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Journal Article
In Vitro and Clinical Compassionate Use Experiences with the Drug-Repurposing Approach CUSP9v3 in Glioblastoma
Halatsch, Marc-Eric, Dwucet, Annika, Schmidt, Carl Julius, Mühlnickel, Julius, Heiland, Tim, Zeiler, Katharina, Siegelin, Markus D, Kast, Richard Eric, Karpel-Massler, Georg
Published in Pharmaceuticals (Basel, Switzerland) (29.11.2021)
Published in Pharmaceuticals (Basel, Switzerland) (29.11.2021)
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Journal Article
Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide’s antiproliferative effect
Karpel-Massler, Georg, Kast, Richard Eric, Westhoff, Mike-Andrew, Dwucet, Annika, Welscher, Nathalie, Nonnenmacher, Lisa, Hlavac, Michal, Siegelin, Markus David, Wirtz, Christian Rainer, Debatin, Klaus-Michael, Halatsch, Marc-Eric
Published in Journal of neuro-oncology (01.03.2015)
Published in Journal of neuro-oncology (01.03.2015)
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Journal Article
Combined inhibition of HER1/EGFR and RAC1 results in a synergistic antiproliferative effect on established and primary cultured human glioblastoma cells
Karpel-Massler, Georg, Westhoff, M-Andrew, Zhou, Shaoxia, Nonnenmacher, Lisa, Dwucet, Annika, Kast, Richard E, Bachem, Max G, Wirtz, Christian R, Debatin, Klaus-Michael, Halatsch, Marc-Eric
Published in Molecular cancer therapeutics (01.09.2013)
Published in Molecular cancer therapeutics (01.09.2013)
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Journal Article
Artesunate enhances the antiproliferative effect of temozolomide on U87MG and A172 glioblastoma cell lines
Karpel-Massler, Georg, Westhoff, Mike-Andrew, Kast, Richard E, Dwucet, Annika, Nonnenmacher, Lisa, Wirtz, C Rainer, Debatin, Klaus-Michael, Halatsch, Marc-Eric
Published in Anti-cancer agents in medicinal chemistry (01.02.2014)
Published in Anti-cancer agents in medicinal chemistry (01.02.2014)
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Journal Article
ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression
Dwucet, Annika, Pruss, Maximilian, Cao, Qiyu, Tanriover, Mine, Prabhu, Varun V, Allen, Joshua E, Peraud, Aurelia, Westhoff, Mike-Andrew, Siegelin, Markus D, Wirtz, Christian Rainer, Karpel-Massler, Georg
Published in Frontiers in cell and developmental biology (26.11.2021)
Published in Frontiers in cell and developmental biology (26.11.2021)
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Journal Article
EXTH-68. DUAL METABOLIC REPROGRAMMING BY ONC201/TIC10 AND 2-DEOXYGLUCOSE HAS A STRONG ANTIPROLIFERATIVE EFFECT ON MEDULLOBLASTOMA CELLS
Dwucet, Annika, Cao, Qiyu, Pruss, Maximilian, Westhoff, Mike-Andrew, Wirtz, Christian Rainer, Siegelin, Markus D, Karpel-Massler, Georg
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
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Journal Article
Bcl‐2/Bcl‐xL inhibition predominantly synergistically enhances the anti‐neoplastic activity of a low‐dose CUSP9 repurposed drug regime against glioblastoma
Halatsch, Marc‐Eric, Kast, Richard Eric, Dwucet, Annika, Hlavac, Michal, Heiland, Tim, Westhoff, Mike‐Andrew, Debatin, Klaus‐Michael, Wirtz, Christian Rainer, Siegelin, Markus David, Karpel‐Massler, Georg
Published in British journal of pharmacology (01.09.2019)
Published in British journal of pharmacology (01.09.2019)
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Journal Article
EXTH-54. Bcl-2/Bcl-xL INHIBITION SYNERGISTICALLY ENHANCES THE ANTI-NEOPLASTIC ACTIVITY OF CUSP9 AGAINST GLIOBLASTOMA CELLS IN VITRO
Halatsch, Marc-Eric, Kast, Richard Eric, Dwucet, Annika, Wirtz, Christian Rainer, Siegelin, Markus, Karpel-Massler, Georg
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
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Journal Article
EXTH-45. THE REPURPOSED CUSP9 REGIMEN EXERTS POTENT ANTI-NEOPLASTIC ACTIVITY AGAINST GLIOBLASTOMA CELLS IN VITRO
Halatsch, Marc-Eric, Kast, Richard Eric, Dwucet, Annika, Siegelin, Markus, Heiland, Tim, Karpel-Massler, Georg
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
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Journal Article
CBMT-35. METABOLIC REWIRING BY ONC201/TIC10 AND 2-DEOXYGLUCOSE HAS SYNERGISTIC ANTI-GLIOBLASTOMA ACTIVITY
Pruss, Maximilian, Dwucet, Annika, Hlavac, Michal, Kast, Richard, Westhoff, Mike-Andrew, Wirtz, Rainer, Halatsch, Marc-Eric, Siegelin, Markus, Karpel-Massler, Georg
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
Published in Neuro-oncology (Charlottesville, Va.) (11.11.2019)
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Journal Article
A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
Halatsch, Marc-Eric, Kast, Richard E, Karpel-Massler, Georg, Mayer, Benjamin, Zolk, Oliver, Schmitz, Bernd, Scheuerle, Angelika, Maier, Ludwig, Bullinger, Lars, Mayer-Steinacker, Regine, Schmidt, Carl, Zeiler, Katharina, Elshaer, Ziad, Panther, Patricia, Schmelzle, Birgit, Hallmen, Anke, Dwucet, Annika, Siegelin, Markus D, Westhoff, Mike-Andrew, Beckers, Kristine, Bouche, Gauthier, Heiland, Tim
Published in Neuro-oncology advances (01.01.2021)
Published in Neuro-oncology advances (01.01.2021)
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Journal Article
CTNI-04. RECURRENT GLIOBLASTOMA LONG-TERM SURVIVORS TREATED WITH CUSP9v3
Halatsch, Marc-Eric, Kast, Richard, Karpel-Massler, Georg, Mayer, Benjamin, Zolk, Oliver, Schmitz, Bernd, Scheuerle, Angelika, Maier, Ludwig, Bullinger, Lars, Mayer-Steinacker, Regine, Schmidt, Carl, Zeiler, Katharina, Elshaer, Ziad, Panther, Patricia, Schmelzle, Birgit, Hallmen, Anke, Dwucet, Annika, Siegelin, Markus D, Westhoff, Mike-Andrew, Beckers, Kristine, Bouche, Gauthier, Heiland, Tim
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
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Journal Article
Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma
Golla, Carolin, Bilal, Mayas, Dwucet, Annika, Bader, Nicolas, Anthonymuthu, Jenson, Heiland, Tim, Pruss, Maximilian, Westhoff, Mike-Andrew, Siegelin, Markus David, Capanni, Felix, Wirtz, Christian Rainer, Kast, Richard Eric, Halatsch, Marc-Eric, Karpel-Massler, Georg
Published in Cancers (17.08.2021)
Published in Cancers (17.08.2021)
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Journal Article
EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY
Hlavac, Michal, Dwucet, Annika, Westhoff, Mike-Andrew, Kast, Richard Eric, Engelke, Jens, Siegelin, Markus, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Karpel-Massler, Georg
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
Published in Neuro-oncology (Charlottesville, Va.) (05.11.2018)
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Journal Article
EXTH-68. DUAL METABOLIC REPROGRAMMING BY ONC201/TIC10 AND 2-DEOXYGLUCOSE HAS A STRONG ANTIPROLIFERATIVE EFFECT ON MEDULLOBLASTOMA CELLS
Dwucet, Annika, Cao, Qiyu, Pruss, Maximilian, Westhoff, Mike-Andrew, Wirtz, Christian Rainer, Siegelin, Markus D, Karpel-Massler, Georg
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
Published in Neuro-oncology (Charlottesville, Va.) (12.11.2021)
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Journal Article
Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis
Hlavac, Michal, Dwucet, Annika, Kast, Richard Eric, Engelke, Jens, Westhoff, Mike-Andrew, Siegelin, Markus D., Debatin, Klaus-Michael, Wirtz, Christian Rainer, Halatsch, Marc-Eric, Karpel-Massler, Georg
Published in Cellular oncology (Dordrecht) (01.06.2019)
Published in Cellular oncology (Dordrecht) (01.06.2019)
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Journal Article
Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids
Cwiklowska, Kamila, Westhoff, Mike-Andrew, Freisinger, Simon, Dwucet, Annika, Halatsch, Marc-Eric, Knippschild, Uwe, Debatin, Klaus-Michael, Schirmbeck, Reinhold, Winiarski, Lukasz, Oleksyszyn, Jozef, Wirtz, Christian Rainer, Burster, Timo
Published in Oncology letters (01.11.2018)
Published in Oncology letters (01.11.2018)
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