Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine
Chayka, Artem, Česnek, Michal, Kužmová, Erika, Kozák, Jaroslav, Tloušt'ová, Eva, Dvořáková, Alexandra, Strmeň, Timotej, Brož, Břetislav, Osifová, Zuzana, Dračínský, Martin, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Published in Journal of medicinal chemistry (27.06.2024)
Published in Journal of medicinal chemistry (27.06.2024)
Get full text
Journal Article
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties
Kalčic, Filip, Zgarbová, Michala, Hodek, Jan, Chalupský, Karel, Dračínský, Martin, Dvořáková, Alexandra, Strmeň, Timotej, Šebestík, Jaroslav, Baszczyňski, Ondřej, Weber, Jan, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Published in Journal of medicinal chemistry (25.11.2021)
Published in Journal of medicinal chemistry (25.11.2021)
Get full text
Journal Article
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2‑b]pyridazine Derivatives Identified by Scaffold Hopping
Břehová, Petra, Řezníčková, Eva, Škach, Kryštof, Jorda, Radek, Dejmek, Milan, Vojáčková, Veronika, Šála, Michal, Kovalová, Markéta, Dračínský, Martin, Dolníková, Alexandra, Strmeň, Timotej, Kinnertová, Monika, Chalupský, Karel, Dvořáková, Alexandra, Gucký, Tomáš, Mertlíková Kaiserová, Helena, Klener, Pavel, Nencka, Radim, Kryštof, Vladimír
Published in Journal of medicinal chemistry (24.08.2023)
Published in Journal of medicinal chemistry (24.08.2023)
Get full text
Journal Article
Triazinium Ligation: Bioorthogonal Reaction of N1‐Alkyl 1,2,4‐Triazinium Salts
Šlachtová, Veronika, Bellová, Simona, La‐Venia, Agustina, Galeta, Juraj, Dračínský, Martin, Chalupský, Karel, Dvořáková, Alexandra, Mertlíková‐Kaiserová, Helena, Rukovanský, Peter, Dzijak, Rastislav, Vrabel, Milan
Published in Angewandte Chemie International Edition (04.09.2023)
Published in Angewandte Chemie International Edition (04.09.2023)
Get full text
Journal Article
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
Skácel, Jan, Djukic, Stefan, Baszczyňski, Ondřej, Kalčic, Filip, Bílek, Tadeáš, Chalupský, Karel, Kozák, Jaroslav, Dvořáková, Alexandra, Tloušt’ová, Eva, Král’ová, Zuzana, Šmídková, Markéta, Voldřich, Jan, Rumlová, Michaela, Pachl, Petr, Brynda, Jiří, Vučková, Tereza, Fábry, Milan, Snášel, Jan, Pichová, Iva, Řezáčová, Pavlína, Mertlíková-Kaiserová, Helena, Janeba, Zlatko
Published in Journal of medicinal chemistry (25.05.2023)
Published in Journal of medicinal chemistry (25.05.2023)
Get full text
Journal Article
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases
Misehe, Mbilo, Matoušová, Marika, Dvořáková, Alexandra, Hercík, Kamil, Škach, Kryštof, Chalupská, Dominika, Dejmek, Milan, Šála, Michal, Hájek, Miroslav, Boura, Evzen, Mertlíková-Kaiserová, Helena, Nencka, Radim
Published in European journal of medicinal chemistry (15.11.2023)
Published in European journal of medicinal chemistry (15.11.2023)
Get full text
Journal Article
Amidate Prodrugs of 9-[2-(Phosphonomethoxy)Ethyl]Adenine as Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis
Šmídková, Markéta, Dvořáková, Alexandra, Tloušt'ová, Eva, Česnek, Michal, Janeba, Zlatko, Mertlíková-Kaiserová, Helena
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
Published in Antimicrobial Agents and Chemotherapy (01.02.2014)
Get full text
Journal Article
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides
Kocek, Hugo, Chalupská, Dominika, Dejmek, Milan, Dvořáková, Alexandra, Zgarbová, Michala, Šála, Michal, Chalupský, Karel, Krafčíková, Petra, Otava, Tomáš, Drexler, Matúš, Procházková, Eliška, Klepetářová, Blanka, Štefek, Milan, Kozic, Ján, Mertlíková-Kaiserová, Helena, Boura, Evzen, Weber, Jan, Nencka, Radim
Published in MedChemComm (01.08.2024)
Published in MedChemComm (01.08.2024)
Get full text
Journal Article
Rational Design of Highly Potent SARS-CoV‑2 nsp14 Methyltransferase Inhibitors
Štefek, Milan, Chalupská, Dominika, Chalupský, Karel, Zgarbová, Michala, Dvořáková, Alexandra, Krafčíková, Petra, Li, Alice Shi Ming, Šála, Michal, Dejmek, Milan, Otava, Tomáš, Chaloupecká, Ema, Kozák, Jaroslav, Kozic, Ján, Vedadi, Masoud, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Published in ACS omega (01.08.2023)
Published in ACS omega (01.08.2023)
Get full text
Journal Article
Triazinium Ligation: Bioorthogonal Reaction of N 1‐Alkyl 1,2,4‐Triazinium Salts
Šlachtová, Veronika, Bellová, Simona, La‐Venia, Agustina, Galeta, Juraj, Dračínský, Martin, Chalupský, Karel, Dvořáková, Alexandra, Mertlíková‐Kaiserová, Helena, Rukovanský, Peter, Dzijak, Rastislav, Vrabel, Milan
Published in Angewandte Chemie International Edition (04.09.2023)
Published in Angewandte Chemie International Edition (04.09.2023)
Get full text
Journal Article
9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH
Placková, Pavla, Rozumová, Nela, Hrebabecky, Hubert, Sála, Michal, Nencka, Radim, Elbert, Tomás, Dvoráková, Alexandra, Votruba, Ivan, Mertlíková-Kaiserová, Helena
Published in Anticancer research (01.08.2013)
Get full text
Published in Anticancer research (01.08.2013)
Journal Article
Triazinium Ligation: Bioorthogonal Reaction of N 1‐Alkyl 1,2,4‐Triazinium Salts
Šlachtová, Veronika, Bellová, Simona, La‐Venia, Agustina, Galeta, Juraj, Dračínský, Martin, Chalupský, Karel, Dvořáková, Alexandra, Mertlíková‐Kaiserová, Helena, Rukovanský, Peter, Dzijak, Rastislav, Vrabel, Milan
Published in Angewandte Chemie (04.09.2023)
Published in Angewandte Chemie (04.09.2023)
Get full text
Journal Article
Triazinium Ligation: Bioorthogonal Reaction of N1‐Alkyl 1,2,4‐Triazinium Salts
Šlachtová, Veronika, Bellová, Simona, La‐Venia, Agustina, Galeta, Juraj, Dračínský, Martin, Chalupský, Karel, Dvořáková, Alexandra, Mertlíková‐Kaiserová, Helena, Rukovanský, Peter, Dzijak, Rastislav, Vrabel, Milan
Published in Angewandte Chemie (04.09.2023)
Published in Angewandte Chemie (04.09.2023)
Get full text
Journal Article