Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
McLelland, Gian-Luca, Goiran, Thomas, Yi, Wei, Dorval, Geneviève, Chen, Carol X, Lauinger, Nadine D, Krahn, Andrea I, Valimehr, Sepideh, Rakovic, Aleksandar, Rouiller, Isabelle, Durcan, Thomas M, Trempe, Jean-François, Fon, Edward A
Published in eLife (20.04.2018)
Published in eLife (20.04.2018)
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Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
McGoldrick, Philip, Lau, Agnes, You, Zhipeng, Durcan, Thomas M., Robertson, Janice
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Compressive molding of engineered tissues via thermoresponsive hydrogel devices
Cassel de Camps, Camille, Mok, Stephanie, Ashby, Emily, Li, Chen, Lépine, Paula, Durcan, Thomas M, Moraes, Christopher
Published in Lab on a chip (12.04.2023)
Published in Lab on a chip (12.04.2023)
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An Inducible Luminescent System to Explore Parkinson's Disease-Associated Genes
Gandy, Anelya, Maussion, Gilles, Al-Habyan, Sara, Nicouleau, Michael, You, Zhipeng, Chen, Carol X-Q, Abdian, Narges, Aprahamian, Nathalia, Krahn, Andrea I, Larocque, Louise, Durcan, Thomas M, Deneault, Eric
Published in International journal of molecular sciences (31.08.2024)
Published in International journal of molecular sciences (31.08.2024)
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The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases
Coulombe, Benoit, Durcan, Thomas M, Bernard, Geneviève, Moursli, Asmae, Poitras, Christian, Faubert, Denis, Pinard, Maxime
Published in Molecular brain (11.04.2024)
Published in Molecular brain (11.04.2024)
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The Machado―Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability
DURCAN, Thomas M, KONTOGIANNEA, Maria, THORARINSDOTTIR, Thorhildur, FALLON, Lara, WILLIAMS, Aislinn J, DJARMATI, Ana, FANTANEANU, Tadeu, PAULSON, Henry L, FON, Edward A
Published in Human molecular genetics (01.01.2011)
Published in Human molecular genetics (01.01.2011)
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Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons
Sheta, Razan, Teixeira, Maxime, Idi, Walid, Pierre, Marion, de Rus Jacquet, Aurelie, Emond, Vincent, Zorca, Cornelia E., Vanderperre, Benoît, Durcan, Thomas M., Fon, Edward A., Calon, Frédéric, Chahine, Mohamed, Oueslati, Abid
Published in Scientific reports (13.10.2022)
Published in Scientific reports (13.10.2022)
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Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
Laflamme, Carl, McKeever, Paul M, Kumar, Rahul, Schwartz, Julie, Kolahdouzan, Mahshad, Chen, Carol X, You, Zhipeng, Benaliouad, Faiza, Gileadi, Opher, McBride, Heidi M, Durcan, Thomas M, Edwards, Aled M, Healy, Luke M, Robertson, Janice, McPherson, Peter S
Published in eLife (15.10.2019)
Published in eLife (15.10.2019)
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Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications
Ayoubi, Riham, Ryan, Joel, Biddle, Michael S, Alshafie, Walaa, Fotouhi, Maryam, Bolivar, Sara Gonzalez, Ruiz Moleon, Vera, Eckmann, Peter, Worrall, Donovan, McDowell, Ian, Southern, Kathleen, Reintsch, Wolfgang, Durcan, Thomas M, Brown, Claire, Bandrowski, Anita, Virk, Harvinder, Edwards, Aled M, McPherson, Peter, Laflamme, Carl
Published in eLife (23.11.2023)
Published in eLife (23.11.2023)
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Auto-qPCR; a python-based web app for automated and reproducible analysis of qPCR data
Maussion, Gilles, Thomas, Rhalena A., Demirova, Iveta, Gu, Gracia, Cai, Eddie, Chen, Carol X.-Q., Abdian, Narges, Strauss, Theodore J. P., Kelaï, Sabah, Nauleau-Javaudin, Angela, Beitel, Lenore K., Ramoz, Nicolas, Gorwood, Philip, Durcan, Thomas M.
Published in Scientific reports (29.10.2021)
Published in Scientific reports (29.10.2021)
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Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases
Krahn, Andrea I, Wells, Carrow, Drewry, David H, Beitel, Lenore K, Durcan, Thomas M, Axtman, Alison D
Published in ACS chemical neuroscience (01.07.2020)
Published in ACS chemical neuroscience (01.07.2020)
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Transcriptional Dysregulation and Impaired Neuronal Activity in FMR1 Knock-Out and Fragile X Patients’ iPSC-Derived Models
Maussion, Gilles, Rocha, Cecilia, Abdian, Narges, Yang, Dimitri, Turk, Julien, Carrillo Valenzuela, Dulce, Pimentel, Luisa, You, Zhipeng, Morquette, Barbara, Nicouleau, Michael, Deneault, Eric, Higgins, Samuel, Chen, Carol X.-Q., Reintsch, Wolfgang E., Ho, Stanley, Soubannier, Vincent, Lépine, Sarah, Modrusan, Zora, Lund, Jessica, Stephenson, William, Schubert, Rajib, Durcan, Thomas M.
Published in International journal of molecular sciences (01.10.2023)
Published in International journal of molecular sciences (01.10.2023)
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Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria
Vranas, Marta, Lu, Yang, Rasool, Shafqat, Croteau, Nathalie, Krett, Jonathan D, Sauvé, Véronique, Gehring, Kalle, Fon, Edward A, Durcan, Thomas M, Trempe, Jean-François
Published in Open biology (2022)
Published in Open biology (2022)
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An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids
Castellanos-Montiel, María José, Chaineau, Mathilde, Franco-Flores, Anna Kristyna, Haghi, Ghazal, Carrillo-Valenzuela, Dulce, Reintsch, Wolfgang E, Chen, Carol X-Q, Durcan, Thomas M
Published in Cells (Basel, Switzerland) (08.02.2023)
Published in Cells (Basel, Switzerland) (08.02.2023)
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Disruption of GRIN2B Impairs Differentiation in Human Neurons
Bell, Scott, Maussion, Gilles, Jefri, Malvin, Peng, Huashan, Theroux, Jean-Francois, Silveira, Heika, Soubannier, Vincent, Wu, Hanrong, Hu, Peng, Galat, Ekaterina, Torres-Platas, S. Gabriela, Boudreau-Pinsonneault, Camille, O'Leary, Liam A., Galat, Vasiliy, Turecki, Gustavo, Durcan, Thomas M., Fon, Edward A., Mechawar, Naguib, Ernst, Carl
Published in Stem cell reports (10.07.2018)
Published in Stem cell reports (10.07.2018)
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