Synthesis and Pharmacological Evaluation of N-(2,5-Disubstituted phenyl)-N‘-(3-substituted phenyl)-N‘-methylguanidines As N-Methyl-d-aspartate Receptor Ion-Channel Blockers
Hu, Lain-Yen, Guo, Junqing, Magar, Sharad S, Fischer, James B, Burke-Howie, Kathleen J, Durant, Graham J
Published in Journal of medicinal chemistry (19.12.1997)
Published in Journal of medicinal chemistry (19.12.1997)
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Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies
Tedford, C E, Yates, S L, Pawlowski, G P, Nalwalk, J W, Hough, L B, Khan, M A, Phillips, J G, Durant, G J, Frederickson, R C
Published in The Journal of pharmacology and experimental therapeutics (01.11.1995)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1995)
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Synthesis and Pharmacological Evaluation of N,N‘-Diarylguanidines as Potent Sodium Channel Blockers and Anticonvulsant Agents
Reddy, N. Laxma, Fan, Wenhong, Magar, Sharad S, Perlman, Michael E, Yost, Elizabeth, Zhang, Lu, Berlove, David, Fischer, James B, Burke-Howie, Kathy, Wolcott, Teresa, Durant, Graham J
Published in Journal of medicinal chemistry (13.08.1998)
Published in Journal of medicinal chemistry (13.08.1998)
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Journal Article
The pharmacology of cimetidine, a new histamine H 2 ‐receptor antagonist
Brimblecombe, RW, Duncan, WAM, Durant, GJ, Ganellin, CR, Parsons, ME, Black, JW
Published in British journal of pharmacology (01.07.2010)
Published in British journal of pharmacology (01.07.2010)
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The pharmacology of cimetidine, a new histamine H2-receptor antagonist. 1975
Brimblecombe, R W, Duncan, W A M, Durant, G J, Ganellin, C R, Parsons, M E, Black, J W
Published in British journal of pharmacology (01.07.2010)
Published in British journal of pharmacology (01.07.2010)
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Journal Article
The histamine H2-receptor agonist impromidine: synthesis and structure activity considerations
Durant, G. J, Ganellin, C. R, Hills, D. W, Miles, P. D, Parsons, M. E, Pepper, E. S, White, G. R
Published in Journal of medicinal chemistry (01.10.1985)
Published in Journal of medicinal chemistry (01.10.1985)
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Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors
Durant, G J, Duncan, W A, Ganellin, C R, Parsons, M E, Blakemore, R C, Rasmussen, A C
Published in Nature (London) (23.11.1978)
Published in Nature (London) (23.11.1978)
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Cimetidine—A Non-Thiourea H2-Receptor Antagonist
Brimblecombe, R W, Duncan, W A M, Durant, G J, Emmett, J C, Ganellin, C R, Parsons, M E
Published in Journal of international medical research (01.03.1975)
Published in Journal of international medical research (01.03.1975)
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Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels
Maillard, Michel C, Perlman, Michael E, Amitay, Oved, Baxter, Deborah, Berlove, David, Connaughton, Sonia, Fischer, James B, Guo, Jun Qing, Hu, Lain-Yen, McBurney, Robert N, Nagy, Peter I, Subbarao, Katragadda, Yost, Elizabeth A, Zhang, Lu, Durant, Graham J
Published in Journal of medicinal chemistry (30.07.1998)
Published in Journal of medicinal chemistry (30.07.1998)
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Structures of histamine H1-receptor antagonists derived from the cimetidine group of histamine H2-receptor antagonists
Bannister, C, Burns, K, Prout, K, Watkin, D J, Cooper, D G, Duránt, G J, Ganellin, C R, Ife, R J, Sach, G S
Published in Acta crystallographica. Section B, Structural science (01.04.1994)
Published in Acta crystallographica. Section B, Structural science (01.04.1994)
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Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydropyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M1 Muscarinic Receptor Agonists
Dunbar, Philip G, Durant, Graham J, Rho, Taikyun, Ojo, Babatunde, Huzl, James J. III, Smith, Douglas A, El-Assadi, Afif A, Sbeih, Sbeih, Ngur, Dan O
Published in Journal of medicinal chemistry (01.08.1994)
Published in Journal of medicinal chemistry (01.08.1994)
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Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists
Dunbar, Philip G, Durant, Graham J, Fang, Zheng, Abuh, Yahaya F, El-Assadi, Afif A, Ngur, Dan O, Periyasamy, Sumudra, Hoss, Wayne P, Messer, William S
Published in Journal of medicinal chemistry (01.04.1993)
Published in Journal of medicinal chemistry (01.04.1993)
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Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers
Padmanabhan, Seetharamaiyer, Lavin, Ruth C, Thakker, Paresh M, Guo, Jinqing, Zhang, Lu, Moore, Deke, Perlman, Michael E, Kirk, Cassandra, Daly, Deborah, Burke-Howie, Kathy J, Wolcott, Teresa, Chari, Suchitra, Berlove, David, Fischer, James B, Holt, William F, Durant, Graham J, McBurney, Robert N
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
Published in Bioorganic & medicinal chemistry letters (17.12.2001)
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Identification and characterization of a potential ischemia-selective N-methyl- d-aspartate (NMDA) receptor ion-channel blocker, CNS 5788
Padmanabhan, Seetharamaiyer, Perlman, Michael E, Zhang, Lu, Moore, Deke, Zhou, Dan, Fischer, James B, Durant, Graham J, McBurney, Robert N
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
Published in Bioorganic & medicinal chemistry letters (26.02.2001)
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Journal Article
Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation
Cooper, D G, Durant, G J, Ganellin, C R, Ife, R J, Meeson, M L, Sach, G S
Published in Farmaco (Società chimica italiana : 1989) (01.01.1991)
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Published in Farmaco (Società chimica italiana : 1989) (01.01.1991)
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