The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
Slade, Dea, Dunstan, Mark S., Barkauskaite, Eva, Weston, Ria, Lafite, Pierre, Dixon, Neil, Ahel, Marijan, Leys, David, Ahel, Ivan
Published in Nature (London) (29.09.2011)
Published in Nature (London) (29.09.2011)
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Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
Barkauskaite, Eva, Brassington, Amy, Tan, Edwin S., Warwicker, Jim, Dunstan, Mark S., Banos, Benito, Lafite, Pierre, Ahel, Marijan, Mitchison, Timothy J., Ahel, Ivan, Leys, David
Published in Nature communications (06.08.2013)
Published in Nature communications (06.08.2013)
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Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis
Gahloth, Deepankar, Dunstan, Mark S, Quaglia, Daniela, Klumbys, Evaldas, Lockhart-Cairns, Michael P, Hill, Andrew M, Derrington, Sasha R, Scrutton, Nigel S, Turner, Nicholas J, Leys, David
Published in Nature chemical biology (01.09.2017)
Published in Nature chemical biology (01.09.2017)
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Reductive dehalogenase structure suggests a mechanism for B12-dependent dehalogenation
Payne, Karl A. P., Quezada, Carolina P., Fisher, Karl, Dunstan, Mark S., Collins, Fraser A., Sjuts, Hanno, Levy, Colin, Hay, Sam, Rigby, Stephen E. J., Leys, David
Published in Nature (London) (22.01.2015)
Published in Nature (London) (22.01.2015)
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Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli
Jervis, Adrian J, Carbonell, Pablo, Vinaixa, Maria, Dunstan, Mark S, Hollywood, Katherine A, Robinson, Christopher J, Rattray, Nicholas J. W, Yan, Cunyu, Swainston, Neil, Currin, Andrew, Sung, Rehana, Toogood, Helen, Taylor, Sandra, Faulon, Jean-Loup, Breitling, Rainer, Takano, Eriko, Scrutton, Nigel S
Published in ACS synthetic biology (18.01.2019)
Published in ACS synthetic biology (18.01.2019)
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Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides
Wood, Alexander J. L., Weise, Nicholas J., Frampton, Joseph D., Dunstan, Mark S., Hollas, Michael A., Derrington, Sasha R., Lloyd, Richard C., Quaglia, Daniela, Parmeggiani, Fabio, Leys, David, Turner, Nicholas J., Flitsch, Sabine L.
Published in Angewandte Chemie International Edition (13.11.2017)
Published in Angewandte Chemie International Edition (13.11.2017)
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Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase
Dunstan, Mark S., Barkauskaite, Eva, Lafite, Pierre, Knezevic, Claire E., Brassington, Amy, Ahel, Marijan, Hergenrother, Paul J., Leys, David, Ahel, Ivan
Published in Nature communications (06.06.2012)
Published in Nature communications (06.06.2012)
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Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase
Parmeggiani, Fabio, Ahmed, Syed T., Thompson, Matthew P., Weise, Nicholas J., Galman, James L., Gahloth, Deepankar, Dunstan, Mark S., Leys, David, Turner, Nicholas J.
Published in Advanced synthesis & catalysis (20.10.2016)
Published in Advanced synthesis & catalysis (20.10.2016)
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Engineering Escherichia coli towards de novo production of gatekeeper (2 S )-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol
Dunstan, Mark S, Robinson, Christopher J, Jervis, Adrian J, Yan, Cunyu, Carbonell, Pablo, Hollywood, Katherine A, Currin, Andrew, Swainston, Neil, Feuvre, Rosalind Le, Micklefield, Jason, Faulon, Jean-Loup, Breitling, Rainer, Turner, Nicholas, Takano, Eriko, Scrutton, Nigel S
Published in ACS synthetic biology (01.01.2020)
Published in ACS synthetic biology (01.01.2020)
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Journal Article
Modular Riboswitch Toolsets for Synthetic Genetic Control in Diverse Bacterial Species
Robinson, Christopher J, Vincent, Helen A, Wu, Ming-Cheng, Lowe, Phillip T, Dunstan, Mark S, Leys, David, Micklefield, Jason
Published in Journal of the American Chemical Society (30.07.2014)
Published in Journal of the American Chemical Society (30.07.2014)
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Reengineering orthogonally selective riboswitches
Dixon, Neil, Duncan, John N, Geerlings, Torsten, Dunstan, Mark S, McCarthy, John E.G, Leys, David, Micklefield, Jason
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2010)
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Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers
Robinson, Christopher J., Carbonell, Pablo, Jervis, Adrian J., Yan, Cunyu, Hollywood, Katherine A., Dunstan, Mark S., Currin, Andrew, Swainston, Neil, Spiess, Reynard, Taylor, Sandra, Mulherin, Paul, Parker, Steven, Rowe, William, Matthews, Nicholas E., Malone, Kirk J., Le Feuvre, Rosalind, Shapira, Philip, Barran, Perdita, Turner, Nicholas J., Micklefield, Jason, Breitling, Rainer, Takano, Eriko, Scrutton, Nigel S.
Published in Metabolic engineering (01.07.2020)
Published in Metabolic engineering (01.07.2020)
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SpeedyGenesXL: an Automated, High-Throughput Platform for the Preparation of Bespoke Ultralarge Variant Libraries for Directed Evolution
Sadler, Joanna C, Swainston, Neil, Dunstan, Mark S, Currin, Andrew, Kell, Douglas B
Published in Methods in molecular biology (Clifton, N.J.) (2022)
Published in Methods in molecular biology (Clifton, N.J.) (2022)
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Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes
Weise, Nicholas J., Ahmed, Syed T., Parmeggiani, Fabio, Galman, James L., Dunstan, Mark S., Charnock, Simon J., Leys, David, Turner, Nicholas J.
Published in Scientific reports (20.10.2017)
Published in Scientific reports (20.10.2017)
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Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets
Robinson, Christopher J, Tellechea-Luzardo, Jonathan, Carbonell, Pablo, Jervis, Adrian J, Yan, Cunyu, Hollywood, Katherine A, Dunstan, Mark S, Currin, Andrew, Takano, Eriko, Scrutton, Nigel S
Published in Biochemical Society transactions (30.06.2021)
Published in Biochemical Society transactions (30.06.2021)
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SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli
Jervis, Adrian J, Carbonell, Pablo, Taylor, Sandra, Sung, Rehana, Dunstan, Mark S, Robinson, Christopher J, Breitling, Rainer, Takano, Eriko, Scrutton, Nigel S
Published in ACS synthetic biology (19.07.2019)
Published in ACS synthetic biology (19.07.2019)
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An automated pipeline for the screening of diverse monoterpene synthase libraries
Leferink, Nicole G. H., Dunstan, Mark S., Hollywood, Katherine A., Swainston, Neil, Currin, Andrew, Jervis, Adrian J., Takano, Eriko, Scrutton, Nigel S.
Published in Scientific reports (15.08.2019)
Published in Scientific reports (15.08.2019)
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Journal Article
Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase
Bennett, Matthew R., Thompson, Mark L., Shepherd, Sarah A., Dunstan, Mark S., Herbert, Abigail J., Smith, Duncan R. M., Cronin, Victoria A., Menon, Binuraj R. K., Levy, Colin, Micklefield, Jason
Published in Angewandte Chemie International Edition (13.08.2018)
Published in Angewandte Chemie International Edition (13.08.2018)
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