Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
Dunford, Paul J., MSc, Williams, Kacy N., BS, Desai, Pragnya J., MSc, Karlsson, Lars, MD, PhD, McQueen, Daniel, PhD, Thurmond, Robin L., PhD
Published in Journal of allergy and clinical immunology (2007)
Published in Journal of allergy and clinical immunology (2007)
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The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis
Cowden, Jeffery M, Yu, Fuqu, Banie, Homayon, Farahani, Mandana, Ling, Ping, Nguyen, Steven, Riley, Jason P, Zhang, Mai, Zhu, Jian, Dunford, Paul J, Thurmond, Robin L
Published in Annals of the rheumatic diseases (01.03.2014)
Published in Annals of the rheumatic diseases (01.03.2014)
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The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
Manthey, Carl L, Moore, Beverley A, Chen, Yanqing, Loza, Matthew J, Yao, Xiang, Liu, Hao, Belkowski, Stanley M, Raymond-Parks, Holly, Dunford, Paul J, Leon, Francisco, Towne, Jennifer E, Plevy, Scott E
Published in PloS one (11.11.2019)
Published in PloS one (11.11.2019)
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A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties
Thurmond, Robin L, Desai, Pragnya J, Dunford, Paul J, Fung-Leung, Wai-Ping, Hofstra, Claudia L, Jiang, Wen, Nguyen, Steven, Riley, Jason P, Sun, Siquan, Williams, Kacy N, Edwards, James P, Karlsson, Lars
Published in The Journal of pharmacology and experimental therapeutics (01.04.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2004)
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Anti-Inflammatory Activity of a Potent, Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton
Rao, Navin L, Dunford, Paul J, Xue, Xiaohua, Jiang, Xiaohui, Lundeen, Katherine A, Coles, Fawn, Riley, Jason P, Williams, Kacy N, Grice, Cheryl A, Edwards, James P, Karlsson, Lars, Fourie, Anne M
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
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Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo
Cowden, Jeffery M., Yu, Fuqu, Challapalli, Mamatha, Huang, Jing-Feng, Kim, Sunhwa, Fung-Leung, Wai-Ping, Ma, Jing Ying, Riley, Jason P., Zhang, Mai, Dunford, Paul J., Thurmond, Robin L.
Published in Inflammation research (01.06.2013)
Published in Inflammation research (01.06.2013)
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A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker
Crawford, Shelby, Belajic, Daniel, Wei, Jianmei, Riley, Jason P, Dunford, Paul J, Bembenek, Scott, Fourie, Anne, Edwards, James P, Karlsson, Lars, Brunmark, Anders, Wolin, Ronald L, Blevitt, Jonathan M
Published in Molecular cancer therapeutics (01.03.2008)
Published in Molecular cancer therapeutics (01.03.2008)
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The histamine H₄ receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects
Kollmeier, Alexa, Francke, Klaus, Chen, Bin, Dunford, Paul J, Greenspan, Andrew J, Xia, Yichuan, Xu, Xie L, Zhou, Bei, Thurmond, Robin L
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2014)
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Journal Article
The histamine H 4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis
Cowden, Jeffery M, Yu, Fuqu, Banie, Homayon, Farahani, Mandana, Ling, Ping, Nguyen, Steven, Riley, Jason P, Zhang, Mai, Zhu, Jian, Dunford, Paul J, Thurmond, Robin L
Published in Annals of the rheumatic diseases (01.03.2014)
Published in Annals of the rheumatic diseases (01.03.2014)
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The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells
Dunford, Paul J, O'Donnell, Niall, Riley, Jason P, Williams, Kacy N, Karlsson, Lars, Thurmond, Robin L
Published in The Journal of immunology (1950) (01.06.2006)
Published in The Journal of immunology (1950) (01.06.2006)
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The histamine H4 receptor: A novel modulator of inflammatory and immune disorders
Zhang, Mai, Thurmond, Robin L., Dunford, Paul J.
Published in Pharmacology & therapeutics (Oxford) (01.03.2007)
Published in Pharmacology & therapeutics (Oxford) (01.03.2007)
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Toreforant, an orally active histamine H 4 -receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study
Boyle, David L, DePrimo, Samuel E, Calderon, Cesar, Chen, Dion, Dunford, Paul J, Barchuk, William, Firestein, Gary S, Thurmond, Robin L
Published in Inflammation research (03.04.2019)
Published in Inflammation research (03.04.2019)
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Journal Article
Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study
Boyle, David L., DePrimo, Samuel E., Calderon, Cesar, Chen, Dion, Dunford, Paul J., Barchuk, William, Firestein, Gary S., Thurmond, Robin L.
Published in Inflammation research (01.04.2019)
Published in Inflammation research (01.04.2019)
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