DNA-encoded chemistry: enabling the deeper sampling of chemical space
Goodnow, Robert A., Dumelin, Christoph E., Keefe, Anthony D.
Published in Nature reviews. Drug discovery (01.02.2017)
Published in Nature reviews. Drug discovery (01.02.2017)
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Journal Article
Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery
Ottl, Johannes, Leder, Lukas, Schaefer, Jonas V, Dumelin, Christoph E
Published in Molecules (Basel, Switzerland) (25.04.2019)
Published in Molecules (Basel, Switzerland) (25.04.2019)
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Journal Article
Small-molecule discovery from DNA-encoded chemical libraries
Kleiner, Ralph E, Dumelin, Christoph E, Liu, David R
Published in Chemical Society reviews (01.01.2011)
Published in Chemical Society reviews (01.01.2011)
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Journal Article
A DNA-based molecular probe for optically reporting cellular traction forces
Blakely, Brandon L, Dumelin, Christoph E, Trappmann, Britta, McGregor, Lynn M, Choi, Colin K, Anthony, Peter C, Duesterberg, Van K, Baker, Brendon M, Block, Steven M, Liu, David R, Chen, Christopher S
Published in Nature methods (01.12.2014)
Published in Nature methods (01.12.2014)
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Journal Article
Discovery and biological characterization of geranylated RNA in bacteria
Dumelin, Christoph E, Chen, Yiyun, Leconte, Aaron M, Chen, Y Grace, Liu, David R
Published in Nature chemical biology (01.11.2012)
Published in Nature chemical biology (01.11.2012)
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Journal Article
Structural insight into allosteric modulation of protease-activated receptor 2
Cheng, Robert K. Y., Fiez-Vandal, Cédric, Schlenker, Oliver, Edman, Karl, Aggeler, Birte, Brown, Dean G., Brown, Giles A., Cooke, Robert M., Dumelin, Christoph E., Doré, Andrew S., Geschwindner, Stefan, Grebner, Christoph, Hermansson, Nils-Olov, Jazayeri, Ali, Johansson, Patrik, Leong, Louis, Prihandoko, Rudi, Rappas, Mathieu, Soutter, Holly, Snijder, Arjan, Sundström, Linda, Tehan, Benjamin, Thornton, Peter, Troast, Dawn, Wiggin, Giselle, Zhukov, Andrei, Marshall, Fiona H., Dekker, Niek
Published in Nature (London) (04.05.2017)
Published in Nature (London) (04.05.2017)
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Journal Article
Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
Litovchick, Alexander, Dumelin, Christoph E., Habeshian, Sevan, Gikunju, Diana, Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Sigel, Eric A., Cuozzo, John W., Keefe, Anthony D., Clark, Matthew A.
Published in Scientific reports (10.06.2015)
Published in Scientific reports (10.06.2015)
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Journal Article
Label-free determination of protein-ligand binding constants using mass spectrometry and validation using surface plasmon resonance and isothermal titration calorimetry
Jecklin, Matthias C., Schauer, Stefan, Dumelin, Christoph E., Zenobi, Renato
Published in Journal of molecular recognition (01.07.2009)
Published in Journal of molecular recognition (01.07.2009)
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Journal Article
Isolation of High-Affinity Trypsin Inhibitors from a DNA-Encoded Chemical Library
Melkko, Samu, Zhang, Yixin, Dumelin, Christoph E., Scheuermann, Jörg, Neri, Dario
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Journal Article
Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment
McGregor, Lynn M, Gorin, David J, Dumelin, Christoph E, Liu, David R
Published in Journal of the American Chemical Society (10.11.2010)
Published in Journal of the American Chemical Society (10.11.2010)
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Journal Article
Advancements in Assay Technologies and Strategies to Enable Drug Discovery
Busby, Scott A., Carbonneau, Seth, Concannon, John, Dumelin, Christoph E., Lee, YounKyoung, Numao, Shin, Renaud, Nicole, Smith, Thomas M., Auld, Douglas S.
Published in ACS chemical biology (16.10.2020)
Published in ACS chemical biology (16.10.2020)
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Journal Article
Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches
Vulpetti, Anna, Rondeau, Jean-Michel, Bellance, Marie-Hélène, Blank, Jutta, Boesch, Ralf, Boettcher, Andreas, Bornancin, Frédéric, Buhr, Sylvia, Connor, Lauren E., Dumelin, Christoph E., Esser, Oliver, Hediger, Michael, Hintermann, Samuel, Hommel, Ulrich, Koch, Elke, Lapointe, Guillaume, Leder, Lukas, Lehmann, Sylvie, Lehr, Philipp, Meier, Peter, Muller, Lionel, Ostermeier, Daniela, Ramage, Paul, Schiebel-Haddad, Sihame, Smith, Alexander Baxter, Stojanovic, Aleksandar, Velcicky, Juraj, Yamamoto, Rina, Hurth, Konstanze
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Encoded self-assembling chemical libraries
Neri, Dario, Melkko, Samu, Scheuermann, Jörg, Dumelin, Christoph E
Published in Nature biotechnology (01.05.2004)
Published in Nature biotechnology (01.05.2004)
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Journal Article
Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa
Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology
Soutter, Holly H., Centrella, Paolo, Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Guie, Marie-Aude, Habeshian, Sevan, Keefe, Anthony D., Kennedy, Kaitlyn M., Sigel, Eric A., Troast, Dawn M., Zhang, Ying, Ferguson, Andrew D., Davies, Gareth, Stead, Eleanor R., Breed, Jason, Madhavapeddi, Prashanti, Read, Jon A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2016)
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Journal Article
High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
Mannocci, Luca, Zhang, Yixin, Scheuermann, Jörg, Leimbacher, Markus, De Bellis, Gianluca, Rizzi, Ermanno, Dumelin, Christoph, Melkko, Samu, Neri, Dario
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (18.11.2008)
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Journal Article
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás
Published in ACS chemical biology (17.11.2017)
Published in ACS chemical biology (17.11.2017)
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