Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice
de Bree, L Charlotte J, Marijnissen, Renoud J, Kel, Junda M, Rosendahl Huber, Sietske K, Aaby, Peter, Benn, Christine Stabell, Wijnands, Marcel V W, Diavatopoulos, Dimitri A, van Crevel, Reinout, Joosten, Leo A B, Netea, Mihai G, Dulos, John
Published in Frontiers in immunology (30.04.2018)
Published in Frontiers in immunology (30.04.2018)
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Corrigendum: Bacillus Calmette-Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice
de Bree, L Charlotte J, Marijnissen, Renoud J, Kel, Junda M, Rosendahl Huber, Sietske K, Aaby, Peter, Benn, Christine Stabell, Wijnands, Marcel V W, Diavatopoulos, Dimitri A, van Crevel, Reinout, Joosten, Leo A B, Netea, Mihai G, Dulos, John
Published in Frontiers in immunology (2018)
Published in Frontiers in immunology (2018)
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Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis
Marijnissen, Renoud J, Koenders, Marije I, van de Veerdonk, Frank L, Dulos, John, Netea, Mihai G, Boots, Annemieke M H, Joosten, Leo A B, van den Berg, Wim B
Published in PloS one (12.06.2012)
Published in PloS one (12.06.2012)
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APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications
Tai, Yu-Tzu, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Yu, Tengteng, Acharya, Chirag, Wen, Kenneth, Hsieh, Phillip A., Dulos, John, van Elsas, Andrea, Munshi, Nikhil, Richardson, Paul, Anderson, Kenneth C.
Published in Leukemia (01.02.2019)
Published in Leukemia (01.02.2019)
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Bion-1301 Blocks APRIL-Induced Anti-Apoptotic Signaling, Immune Suppressive Phenotype, and Chemokine Production Associated with Multiple Myeloma
Bakker, Jeroen, Habraken, Maurice, Dulos, John, Tai, Yu-Tzu, Van Elsas, Andrea, Vink, Paul, Eenennaam, Hans
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
Dulos, John, Carven, Gregory J, van Boxtel, Susan J, Evers, Sabine, Driessen-Engels, Lilian J A, Hobo, Willemijn, Gorecka, Monika A, de Haan, Anton F J, Mulders, Peter, Punt, Cornelis J A, Jacobs, Joannes F M, Schalken, Jack A, Oosterwijk, Egbert, van Eenennaam, Hans, Boots, Annemieke M
Published in Journal of immunotherapy (1997) (01.02.2012)
Published in Journal of immunotherapy (1997) (01.02.2012)
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Abstract 3780: Preclinical pharmacokinetics, pharmacodynamics and safety of BION-1301, a first-in-class antibody targeting APRIL for the treatment of multiple myeloma
Dulos, John, Driessen, Lilian, Zandvoort, Peter van, Crommert, Jos van de, Nair, Nitya, Randlev, Britta, Cock, Eduard de, Schaap, Jeroen Elassaiss, Eenennaam, Hans van, Elsas, Andrea van
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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A First in Class APRIL Fully Blocking Antibody Targets Novel Immune Regulation of APRIL in Multiple Myeloma: Further Therapeutic Implication
Lin, Liang, Xing, Lijie, Acharya, Chirag M, Wen, Kenneth, Hsieh, Phillip, Dulos, John, Van Elsas, Andrea, Munshi, Nikhil, Richardson, Paul G, Anderson, Kenneth C, Tai, Yu-Tzu
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Bion-1301, a First-in-Class APRIL Neutralizing Antibody for the Treatment of Multiple Myeloma: Preclinical Safety, and Analysis of Pharmacokinetics — Pharmacodynamics Relationship
Dulos, John, Driessen, Lilian, van Zandvoort, Peter, van de Crommert, Jos, Skoble, Justin, Nair, Nitya, Randlev, Britta, de Cock, Eduard, Elassaiss Schaap, Jeroen, Eenennaam, Hans, van Elsas, Andrea
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab
Hutchins, Beth, Starling, Gary C, McCoy, Mark A, Herzyk, Danuta, Poulet, Frederique M, Dulos, John, Liu, Liming, Kang, Soonmo Peter, Fayadat-Dilman, Laurence, Hsieh, Mark, Andrews, Christine L, Ayanoglu, Gulesi, Cullen, Constance, Malefyt, Rene de Waal, Kastelein, Robert A, Saux, Sabine Le, Lee, Julie, Li, Sophie, Malashock, Dan, Sadekova, Svetlana, Soder, George, van Eenennaam, Hans, Willingham, Aarron, Yu, Ying, Streuli, Michel, Carven, Gregory J, van Elsas, Andrea
Published in Molecular cancer therapeutics (01.06.2020)
Published in Molecular cancer therapeutics (01.06.2020)
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Abstract 2645: Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma
Dulos, John, Driessen, Lilian, Snippert, Marc, Guadagnoli, Marco, Bertens, Astrid, Hulsik, David Lutje, Tzu, Tai Yu, Anderson, Kenneth, Medema, Jan Paul, Cameron, Kate, Eenennaam, Hans, Elsas, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Bion-1301: A Novel Fully Blocking APRIL Antibody for the Treatment of Multiple Myeloma
Dulos, John, Lilian, Driessen, Snippert, Marc, Guadagnoli, Marco, Bertens, Astrid, David, Lutje Hulsik, Yu-Tzu, Tai, Anderson, Kenneth C., Medema, Jan Paul, Cameron, Kate, Eenennaam, Hans, Elsas, Andrea
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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APRIL Is Significantly Elevated at All Stages of Multiple Myeloma (MM) and Interferes with Anti-Bcma Monoclonal Antibody-Mediated Cytolysis, Supporting the Clinical Evaluation of Bion-1301 As a Novel Therapeutic Approach in MM
Tai, Yu-Tzu, Dulos, John, Guelen, Lars, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Wen, Kenneth, Yu, Tengteng, Hsieh, Phillip A, van Zandvoort, Peter, van de Wiel, Guido, van de Crommert, Jos, Lejeune, Bonny, Namini, Hamid, Eenennaam, Hans, van Elsas, Andrea, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4ig but is successfully treated by interleukin-17 neutralization
Koenders, Marije I., Marijnissen, Renoud J., Joosten, Leo A. B., Abdollahi-Roodsaz, Shahla, Di Padova, Franco E., van de Loo, Fons A., Dulos, John, van den Berg, Wim B., Boots, Annemieke M. H.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2012)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.06.2012)
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Therapeutic Antibody Targeting of CD97 in Experimental Arthritis: the Role of Antigen Expression, Shedding, and Internalization on the Pharmacokinetics of Anti-CD97 Monoclonal Antibody 1B2
de Groot, Dorien M, Vogel, Gerard, Dulos, John, Teeuwen, Leonie, Stebbins, Karin, Hamann, Jorg, Owens, Bronwyn M, van Eenennaam, Hans, Bos, Ebo, Boots, Annemieke M
Published in The Journal of immunology (1950) (15.09.2009)
Published in The Journal of immunology (1950) (15.09.2009)
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DHEA metabolism in arthritis: a role for the p450 enzyme Cyp7b at the immune-endocrine crossroad
Dulos, John, Boots, Annemieke H
Published in Annals of the New York Academy of Sciences (01.06.2006)
Published in Annals of the New York Academy of Sciences (01.06.2006)
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Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors
Kaptein, Allard, Oubrie, Arthur, Zwart, Edwin de, Hoogenboom, Niels, Wit, Joeri de, Kar, Bas van de, Hoek, Maaike van, Vogel, Gerard, Kimpe, Vera de, Schultz-Fademrecht, Carsten, Borsboom, Judith, Zeeland, Mario van, Versteegh, Judith, Kazemier, Bert, Roos, Jeroen de, Wijnands, Frank, Dulos, John, Jaeger, Martin, Leandro-Garcia, Paula, Barf, Tjeerd
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor alpha but not estrogen receptor beta
Dulos, John, Vijn, Peter, van Doorn, Cindy, Hofstra, Claudia L, Veening-Griffioen, Desiree, de Graaf, Jan, Dijcks, Fred A, Boots, Annemieke M H
Published in Arthritis research & therapy (01.01.2010)
Published in Arthritis research & therapy (01.01.2010)
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DHEA Metabolism in Arthritis
DULOS, JOHN, BOOTS, ANNEMIEKE H.
Published in Annals of the New York Academy of Sciences (01.06.2006)
Published in Annals of the New York Academy of Sciences (01.06.2006)
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