A role for TREX components in the release of spliced mRNA from nuclear speckle domains
Reed, Robin, Dias, Anusha P, Dufu, Kobina, Lei, Haixin
Published in Nature communications (19.10.2010)
Published in Nature communications (19.10.2010)
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Journal Article
Human mRNA Export Machinery Recruited to the 5′ End of mRNA
Cheng, Hong, Dufu, Kobina, Lee, Chung-Sheng, Hsu, Jeanne L., Dias, Anusha, Reed, Robin
Published in Cell (29.12.2006)
Published in Cell (29.12.2006)
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Journal Article
ATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complex
Dufu, Kobina, Livingstone, Michaela J, Seebacher, Jan, Gygi, Steven P, Wilson, Stuart A, Reed, Robin
Published in Genes & development (15.09.2010)
Published in Genes & development (15.09.2010)
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Journal Article
Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin
Metcalf, Brian, Chuang, Chihyuan, Dufu, Kobina, Patel, Mira P, Silva-Garcia, Abel, Johnson, Carl, Lu, Qing, Partridge, James R, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C, Jacobson, Matthew P, Hua, Lan, Xu, Qing, Gwaltney, Stephen L, Yee, Calvin, Harris, Jason, Morgan, Bradley P, James, Joyce, Xu, Donghong, Hutchaleelaha, Athiwat, Paulvannan, Kumar, Oksenberg, Donna, Li, Zhe
Published in ACS medicinal chemistry letters (09.03.2017)
Published in ACS medicinal chemistry letters (09.03.2017)
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Journal Article
Functional coupling of RNAP II transcription to spliceosome assembly
Das, Rita, Dufu, Kobina, Romney, Ben, Feldt, Megan, Elenko, Mark, Reed, Robin
Published in Genes & development (01.05.2006)
Published in Genes & development (01.05.2006)
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Journal Article
GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise
Dufu, Kobina, Lehrer-Graiwer, Josh, Ramos, Eleanor, Oksenberg, Donna
Published in Hematology reports (28.09.2016)
Published in Hematology reports (28.09.2016)
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Journal Article
The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia
Al Balushi, Halima, Dufu, Kobina, Rees, David C., Brewin, John N., Hannemann, Anke, Oksenberg, Donna, Lu, David C.‐Y., Gibson, John S.
Published in Physiological reports (01.03.2019)
Published in Physiological reports (01.03.2019)
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Journal Article
GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease
Dufu, Kobina, Oksenberg, Donna, Cathers, Brian E, Munoz, Carlos J, Muller, Cynthia R, Pedro Cabrales, Pedro
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease
Dufu, Kobina, Oksenberg, Donna, Cathers, Brian E, Munoz, Carlos J, Muller, Cynthia R, Pedro Cabrales, Pedro
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
Howard, Jo, Hemmaway, Claire Jane, Telfer, Paul, Layton, D. Mark, Porter, John, Awogbade, Moji, Mant, Timothy, Gretler, Daniel D., Dufu, Kobina, Hutchaleelaha, Athiwat, Patel, Mira, Siu, Vincent, Dixon, Sandra, Landsman, Noel, Tonda, Margaret, Lehrer-Graiwer, Joshua
Published in Blood (25.04.2019)
Published in Blood (25.04.2019)
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Journal Article
GBT021601 Increases Hemoglobin and Improves Red Blood Cell Deformability without Rebound Hyperviscosity upon Drug Clearance in a Sickle Mouse Model
Kanne, Celeste K., Liu, Christina, Hernandez, Britney N., Evans, Erica N., Pochron, Mira P., Dufu, Kobina, Sheehan, Vivien A.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Predictive Biomarker Analysis from the GBT021601 Survival Study in Townes Sickle Mice
Pochron, Mira Patel, Sun, Jiaxin, Potdar, Alka A, Alt, Carsten, DeGuzman, Francis, Connor, Michael W., Cathers, Brian, Dufu, Kobina, Archer, David R
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease
Oksenberg, Donna, Dufu, Kobina, Patel, Mira P., Chuang, Chihyuan, Li, Zhe, Xu, Qing, Silva‐Garcia, Abel, Zhou, Chengjing, Hutchaleelaha, Athiwat, Patskovska, Larysa, Patskovsky, Yury, Almo, Steven C., Sinha, Uma, Metcalf, Brian W., Archer, David R.
Published in British journal of haematology (01.10.2016)
Published in British journal of haematology (01.10.2016)
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Journal Article
Pharmacodynamic Results from Phase 1 Studies of GBT021601, a Next-Generation HbS Polymerization Inhibitor for Treatment of Sickle Cell Disease
Idowu, Modupe, Nguyen, Thinh, Lewis, Derek, Lipato, Thokozeni, Buckley, Erin M., Brothers, Rowan, Akbar, Mariam, Triplett, Sydney, Dufu, Kobina, Lisbon, Eleanor
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Evaluation of GBT021601 As a Therapeutic Agent to Restore Bone Marrow Health and Effective Erythropoiesis in a Sickle Mouse Model
Hernandez, Britney, Priyadarshini, Anupama, Kostamo, Zachary, Zhang, Yankai, Patel, Ashwin P, Pendergast, Michael A, Jupelli, Madhulika, Huang, Heli, Nguyen Dang, Annie, Pochron, Mira Patel, Dufu, Kobina, Sheehan, Vivien A
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model
Dufu, Kobina, Alt, Carsten, Strutt, Steven, Tang, Tzechiang, Liao-Zou, Hilary, Yuan, Yue, Cathers, Brian E, Oksenberg, Donna
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice
Dufu, Kobina, Williams, Alexander T., Muller, Cynthia R., Walser, Cynthia M., Lucas, Alfredo, Eaker, Allyn M., Alt, Carsten, Cathers, Brian E., Oksenberg, Donna, Cabrales, Pedro
Published in American journal of physiology. Heart and circulatory physiology (01.08.2021)
Published in American journal of physiology. Heart and circulatory physiology (01.08.2021)
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Journal Article