Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E
Published in Journal of neuroinflammation (01.05.2018)
Published in Journal of neuroinflammation (01.05.2018)
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Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils
Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.
Published in Neurobiology of disease (01.10.2019)
Published in Neurobiology of disease (01.10.2019)
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Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition
Stoll, Anna C, Kemp, Christopher J, Patterson, Joseph R, Kubik, Michael, Kuhn, Nathan, Benskey, Matthew, Duffy, Megan F, Luk, Kelvin C, Sortwell, Caryl E
Published in Journal of neuroinflammation (25.04.2024)
Published in Journal of neuroinflammation (25.04.2024)
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Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents
Polinski, Nicole K., Volpicelli-Daley, Laura A., Sortwell, Caryl E., Luk, Kelvin C., Cremades, Nunilo, Gottler, Lindsey M., Froula, Jessica, Duffy, Megan F., Lee, Virginia M.Y., Martinez, Terina N., Dave, Kuldip D.
Published in Journal of Parkinson's disease (01.01.2018)
Published in Journal of Parkinson's disease (01.01.2018)
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The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats
Mercado, Natosha M., Stancati, Jennifer A., Sortwell, Caryl E., Mueller, Rebecca L., Boezwinkle, Samuel A., Duffy, Megan F., Fischer, D. Luke, Sandoval, Ivette M., Manfredsson, Fredric P., Collier, Timothy J., Steece-Collier, Kathy
Published in Neurobiology of disease (01.01.2021)
Published in Neurobiology of disease (01.01.2021)
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Progress and Challenges in Ocean Metaproteomics and Proposed Best Practices for Data Sharing
Saito, Mak A, Bertrand, Erin M, Duffy, Megan E, Gaylord, David A, Held, Noelle A, Hervey, William Judson, Hettich, Robert L, Jagtap, Pratik D, Janech, Michael G, Kinkade, Danie B, Leary, Dagmar H, McIlvin, Matthew R, Moore, Eli K, Morris, Robert M, Neely, Benjamin A, Nunn, Brook L, Saunders, Jaclyn K, Shepherd, Adam I, Symmonds, Nicholas I, Walsh, David A
Published in Journal of proteome research (05.04.2019)
Published in Journal of proteome research (05.04.2019)
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The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria
Bhattacharjee, Ashima, Yang, Haojun, Duffy, Megan, Robinson, Emily, Conrad-Antoville, Arianrhod, Lu, Ya-Wen, Capps, Tony, Braiterman, Lelita, Wolfgang, Michael, Murphy, Michael P., Yi, Ling, Kaler, Stephen G., Lutsenko, Svetlana, Ralle, Martina
Published in The Journal of biological chemistry (05.08.2016)
Published in The Journal of biological chemistry (05.08.2016)
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Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson's Disease
Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Fischer, D Luke, Stoll, Anna C, Sortwell, Caryl E
Published in Frontiers in neuroscience (04.09.2018)
Published in Frontiers in neuroscience (04.09.2018)
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4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN
Jeong, Suh Young, Hogarth, Penelope, Placzek, Andrew, Gregory, Allison M, Fox, Rachel, Zhen, Dolly, Hamada, Jeffrey, van der Zwaag, Marianne, Lambrechts, Roald, Jin, Haihong, Nilsen, Aaron, Cobb, Jared, Pham, Thao, Gray, Nora, Ralle, Martina, Duffy, Megan, Schwanemann, Leila, Rai, Puneet, Freed, Alison, Wakeman, Katrina, Woltjer, Randall L, Sibon, Ody CM, Hayflick, Susan J
Published in EMBO molecular medicine (01.12.2019)
Published in EMBO molecular medicine (01.12.2019)
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Factorial randomised controlled trial to examine the potential effect of a text message-based intervention on reducing adolescent susceptibility to e-cigarette use: a study protocol
Barnes, Courtney, Turon, Heidi, McCrabb, Sam, Mantach, Stephanie, Janssen, Lisa, Duffy, Megan, Groombridge, Daniel, Hodder, Rebecca, Meharg, David, Robinson, Elly, Bialek, Caitlin, Wallace, Seaneen, Leigh, Lucy, Wolfenden, Luke
Published in BMJ open (17.08.2024)
Published in BMJ open (17.08.2024)
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Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
Patterson, Joseph R, Polinski, Nicole K, Duffy, Megan F, Kemp, Christopher J, Luk, Kelvin C, Volpicelli-Daley, Laura A, Kanaan, Nicholas M, Sortwell, Caryl E
Published in Journal of visualized experiments (02.06.2019)
Published in Journal of visualized experiments (02.06.2019)
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An ANXA11 P93S variant dysregulates TDP‐43 and causes corticobasal syndrome
Snyder, Allison, Ryan, Veronica H., Hawrot, James, Lawton, Sydney, Ramos, Daniel M., Qi, Y. Andy, Johnson, Kory R., Reed, Xylena, Johnson, Nicholas L., Kollasch, Aaron W., Duffy, Megan F., VandeVrede, Lawren, Cochran, J. Nicholas, Miller, Bruce L., Toro, Camilo, Bielekova, Bibiana, Marks, Debora S., Yokoyama, Jennifer S., Kwan, Justin Y., Cookson, Mark R., Ward, Michael E.
Published in Alzheimer's & dementia (01.08.2024)
Published in Alzheimer's & dementia (01.08.2024)
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Preformed fibrils generated from mouse alpha-synuclein produce more inclusion pathology in rats than fibrils generated from rat alpha-synuclein
Howe, Jacob W., Sortwell, Caryl E., Duffy, Megan F., Kemp, Christopher J., Russell, Christopher P., Kubik, Michael, Patel, Pooja, Luk, Kelvin C., El-Agnaf, Omar M.A., Patterson, Joseph R.
Published in Parkinsonism & related disorders (01.08.2021)
Published in Parkinsonism & related disorders (01.08.2021)
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Journal Article
Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression
Fischer, D. Luke, Manfredsson, Fredric P., Kemp, Christopher J., Cole-Strauss, Allyson, Lipton, Jack W., Duffy, Megan F., Polinski, Nicole K., Steece-Collier, Kathy, Collier, Timothy J., Gombash, Sara E., Buhlinger, Daniel J., Sortwell, Caryl E.
Published in Scientific reports (27.11.2017)
Published in Scientific reports (27.11.2017)
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Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme
Bonnemaison, Mathilde L., Bäck, Nils, Duffy, Megan E., Ralle, Martina, Mains, Richard E., Eipper, Betty A.
Published in The Journal of biological chemistry (28.08.2015)
Published in The Journal of biological chemistry (28.08.2015)
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Modulation of tau phosphorylation by environmental copper
Voss, Kellen, Harris, Christopher, Ralle, Martina, Duffy, Megan, Murchison, Charles, Quinn, Joseph F
Published in Translational neurodegeneration (17.11.2014)
Published in Translational neurodegeneration (17.11.2014)
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Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils
Patterson, Joseph R., Kochmanski, Joseph, Stoll, Anna C., Kubik, Michael, Kemp, Christopher J., Duffy, Megan F., Thompson, Kajene, Howe, Jacob W., Cole-Strauss, Allyson, Kuhn, Nathan C., Miller, Kathryn M., Nelson, Seth, Onyekpe, Christopher U., Beck, John S., Counts, Scott E., Bernstein, Alison I., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E.
Published in NPJ Parkinson's Disease (03.01.2024)
Published in NPJ Parkinson's Disease (03.01.2024)
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Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease
Fischer, D Luke, Gombash, Sara E, Kemp, Christopher J, Manfredsson, Fredric P, Polinski, Nicole K, Duffy, Megan F, Sortwell, Caryl E
Published in Methods in molecular biology (Clifton, N.J.) (2016)
Published in Methods in molecular biology (Clifton, N.J.) (2016)
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