An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities
Koci, Bryan, Luerman, Gregory, Duenbostell, Anika, Kettenhofen, Ralf, Bohlen, Heribert, Coyle, Luke, Knight, Brian, Ku, Warren, Volberg, Walter, Woska, Joseph R., Brown, Martha P.
Published in Toxicology and applied pharmacology (15.08.2017)
Published in Toxicology and applied pharmacology (15.08.2017)
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Impedance-Based Assessment of Preclinical Cardiac Structural Toxicity Using Human iPSC-Derived Cardiomyocytes and its Correlation to In Vivo (dog) Exposures
Koci, Bryan, Luerman, Greg, Duenbostell, Anika, Kettenhofen, Ralf, Bohlen, Heribert, Coyle, Luke, Knight, Brian, Ku, Warren, Volberg, Walt, Woska, Joseph, Brown, Martha
Published in Journal of pharmacological and toxicological methods (01.11.2017)
Published in Journal of pharmacological and toxicological methods (01.11.2017)
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Journal Article
The newcomer is getting up and running: Human iPS cell-derived cardiomyocyte implementation in multiple cardiac safety assessment assays
Kettenhofen, Ralf, Duenbostell, Anika, Bertram, Bettina, Gossmann, Matthias, Rascher-Eggstein, Gesa
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Breaking new ground in early cardiac safety: Human cardiomyocytes derived from iPSCs in high-throughput screening
Kettenhofen, Ralf, Duenbostell, Anika, Niedereichholz, Thomas, D'Angelo, Jean Marc, Horai, Hirofumi, Bertram, Bettina
Published in Journal of pharmacological and toxicological methods (01.09.2015)
Published in Journal of pharmacological and toxicological methods (01.09.2015)
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Journal Article
Human iPSC-derived Cor.4U cardiomyocytes as a predictive tool for different comprehensive in vitro proarrhythmia assay endpoints
Kettenhofen, Ralf, Duenbostell, Anika, Luerman, Greg, Li, Ping, Yue, Yimei, Bronson, Jared, Horai, Hirofumi, D'Angelo, Jean Marc, Niedereichholz, Thomas, Gibson, John Ken
Published in Journal of pharmacological and toxicological methods (01.09.2016)
Published in Journal of pharmacological and toxicological methods (01.09.2016)
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Journal Article
Human cardiomyocytes derived from iPS cells: Characterization and assessment of drug-induced changes on action potentials, ion currents, extracellular field potentials and impedance signals
Kettenhofen, Ralf, Numann, Randy, Gibson, John Ken, Hebeisen, Simon, Duenbostell, Anika, Rubenchik, Olga, Tenelsen, Josef, Metzger, Peter, Bohlen, Heribert
Published in Journal of pharmacological and toxicological methods (01.11.2014)
Published in Journal of pharmacological and toxicological methods (01.11.2014)
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