The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K + channels TREK-1 and TRAAK
Meadows, H.J., Chapman, C.G., Duckworth, D.M., Kelsell, R.E., Murdock, P.R., Nasir, S., Rennie, G., Randall, A.D.
Published in Brain research (16.02.2001)
Published in Brain research (16.02.2001)
Get full text
Journal Article
(R)-3,N-Dimethyl-N-[1-methyl-3-(4-methylpiperidin-1-yl)propyl]benzenesulfonamide: The First Selective 5-HT7 Receptor Antagonist
Forbes, Ian T, Dabbs, Steven, Duckworth, D. Malcolm, Jennings, Andrew J, King, Frank D, Lovell, Peter J, Brown, Anthony M, Collin, Lissa, Hagan, Jim J, Middlemiss, Derek N, Riley, Graham J, Thomas, David R, Upton, Neil
Published in Journal of medicinal chemistry (26.02.1998)
Published in Journal of medicinal chemistry (26.02.1998)
Get full text
Journal Article
Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Duckworth, D. Malcolm, Forbes, Ian T, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Starr, Susannah, Thewlis, Kevin M, Wyman, Paul A, Blaney, Frank E, Naylor, Christopher B, Bailey, Fiona, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (07.05.1998)
Published in Journal of medicinal chemistry (07.05.1998)
Get full text
Journal Article
1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines : Novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents
BROMIDGE, S. M, DABBS, S, HOLLAND, V, KENNETT, G. A, LIGHTOWLER, S, MIDDLEMISS, D. N, RILEY, G. J, TRAIL, B, WOOD, M. D, DAVIES, S, DUCKWORTH, D. M, FORBES, I. T, JONES, G. E, JONES, J, KING, F. D, SAUNDERS, D. V, BLACKBURN, T. P
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Published in Bioorganic & medicinal chemistry letters (21.08.2000)
Get full text
Journal Article
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
Hayes, Philip, Meadows, Helen J, Gunthorpe, Martin J, Harries, Mark H, Duckworth, D.Malcolm, Cairns, William, Harrison, David C, Clarke, Catherine E, Ellington, Kathryn, Prinjha, Rab K, Barton, Amanda J.L, Medhurst, Andrew D, Smith, Graham D, Topp, Simon, Murdock, Paul, Sanger, Gareth J, Terrett, John, Jenkins, Owen, Benham, Christopher D, Randall, Andrew D, Gloger, Isro S, Davis, John B
Published in Pain (Amsterdam) (01.11.2000)
Published in Pain (Amsterdam) (01.11.2000)
Get full text
Journal Article
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
Medhurst, Andrew D., Rennie, Gillian, Chapman, Conrad G., Meadows, Helen, Duckworth, Malcolm D., Kelsell, Rosemary E., Gloger, Israel I., Pangalos, Menelas N.
Published in Brain research. Molecular brain research. (31.01.2001)
Published in Brain research. Molecular brain research. (31.01.2001)
Get full text
Journal Article
Antiviral 9-[2-(phosphonomethoxy)alkoxy]purines
Duckworth, D. M., Harnden, M. R., Perkins, R. M., Planterose, D. N.
Published in Antiviral chemistry & chemotherapy (01.08.1991)
Published in Antiviral chemistry & chemotherapy (01.08.1991)
Get full text
Journal Article
Biarylcarbamoylindolines Are Novel and Selective 5-HT2C Receptor Inverse Agonists: Identification of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a Potential Antidepressant/Anxiolytic Agent
Bromidge, Steven M, Dabbs, Steven, Davies, David T, Davies, Susannah, Duckworth, D. Malcolm, Forbes, Ian T, Gaster, Laramie M, Ham, Peter, Jones, Graham E, King, Frank D, Mulholland, Keith R, Saunders, Damian V, Wyman, Paul A, Blaney, Frank E, Clarke, Stephen E, Blackburn, Thomas P, Holland, Vicky, Kennett, Guy A, Lightowler, Sean, Middlemiss, Derek N, Trail, Brenda, Riley, Graham J, Wood, Martyn D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
Get full text
Journal Article
Kinetic modification of the α1I subunit‐mediated T‐type Ca2+ channel by a human neuronal Ca2+ channel γ subunit
Green, P. J., Warre, R., Hayes, P. D., McNaughton, N. C. L., Medhurst, A. D., Pangalos, M., Duckworth, D. M., Randall, A. D.
Published in The Journal of physiology (01.06.2001)
Published in The Journal of physiology (01.06.2001)
Get full text
Journal Article
The Selective 5-HT1B Receptor Inverse Agonist 1‘-Methyl-5-[[2‘-methyl-4‘- (5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4‘-piperidine] (SB-224289) Potently Blocks Terminal 5-HT Autoreceptor Function Both in Vitro and in Vivo
Gaster, Laramie M., Blaney, Frank E., Davies, Susannah, Duckworth, D. Malcolm, Ham, Peter, Jenkins, Sarah, Jennings, Andrew J., Joiner, Graham F., King, Frank D., Mulholland, Keith R., Wyman, Paul A., Hagan, Jim J., Hatcher, Jon, Jones, Brian J., Middlemiss, Derek N., Price, Gary W., Riley, Graham, Roberts, Claire, Routledge, Carol, Selkirk, Julie, Slade, Paula D.
Published in Journal of medicinal chemistry (09.04.1998)
Published in Journal of medicinal chemistry (09.04.1998)
Get full text
Journal Article
Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT2C/2B Receptor Antagonists
Forbes, Ian T, Dabbs, Steven, Duckworth, D. Malcolm, Ham, Peter, Jones, Graham E, King, Frank D, Saunders, Damian V, Blaney, Frank E, Naylor, Christopher B, Baxter, Gordon S, Blackburn, Thomas P, Kennett, Guy A, Wood, Martyn D
Published in Journal of medicinal chemistry (06.12.1996)
Published in Journal of medicinal chemistry (06.12.1996)
Get full text
Journal Article
Model studies on a synthetically facile series of N-substituted phenyl-N'-pyridin-3-yl ureas leading to 1-(3-pyridylcarbamoyl) indolines that are potent and selective 5-HT2C/2B receptor antagonists
BROMIDGE, S. M, DABBS, S, SAUNDERS, D. V, THEWLIS, K. M, VYAS, D, BLACKBURN, T. P, HOLLAND, V, KENNETT, G. A, RILEY, G. J, WOOD, M. D, DAVIES, D. T, DAVIES, S, DUCKWORTH, D. M, FORBES, I. T, GADRE, A, HAM, P, JONES, G. E, KING, F. D
Published in Bioorganic & medicinal chemistry (01.12.1999)
Published in Bioorganic & medicinal chemistry (01.12.1999)
Get full text
Journal Article
Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent
Bromidge, S M, Dabbs, S, Davies, D T, Davies, S, Duckworth, D M, Forbes, I T, Gaster, L M, Ham, P, Jones, G E, King, F D, Mulholland, K R, Saunders, D V, Wyman, P A, Blaney, F E, Clarke, S E, Blackburn, T P, Holland, V, Kennett, G A, Lightowler, S, Middlemiss, D N, Trail, B, Riley, G J, Wood, M D
Published in Journal of medicinal chemistry (23.03.2000)
Published in Journal of medicinal chemistry (23.03.2000)
Get full text
Journal Article
A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Lovell, Peter J, Bromidge, Steven M, Dabbs, Steven, Duckworth, D. Malcolm, Forbes, Ian T, Jennings, Andrew J, King, Frank D, Middlemiss, Derek N, Rahman, Shirley K, Saunders, Damian V, Collin, Lissa L, Hagan, Jim J, Riley, Graham J, Thomas, David R
Published in Journal of medicinal chemistry (10.02.2000)
Published in Journal of medicinal chemistry (10.02.2000)
Get full text
Journal Article
Ex Vivo Major Histocompatibility Complex I Knockdown Prolongs Rejection-free Allograft Survival
Chang, Jessica B, Rifkin, William J, Soares, Marc A, Duckworth, April, Rao, Nakul, Low, Yee Cheng, Massie, Jonathan P, Rabbani, Piul S, Saadeh, Pierre B, Ceradini, Daniel J
Published in Plastic and reconstructive surgery. Global open (01.06.2018)
Published in Plastic and reconstructive surgery. Global open (01.06.2018)
Get full text
Journal Article