Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820
Du, Xinlin, Volkov, Oleg A., Czerwinski, Robert M., Tan, HuiLing, Huerta, Carlos, Morton, Emily R., Rizzi, Jim P., Wehn, Paul M., Xu, Rui, Nijhawan, Deepak, Wallace, Eli M.
Published in Structure (London) (05.11.2019)
Published in Structure (London) (05.11.2019)
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Journal Article
Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
Kato, Masato, Han, Tina W., Xie, Shanhai, Shi, Kevin, Du, Xinlin, Wu, Leeju C., Mirzaei, Hamid, Goldsmith, Elizabeth J., Longgood, Jamie, Pei, Jimin, Grishin, Nick V., Frantz, Douglas E., Schneider, Jay W., Chen, She, Li, Lin, Sawaya, Michael R., Eisenberg, David, Tycko, Robert, McKnight, Steven L.
Published in Cell (11.05.2012)
Published in Cell (11.05.2012)
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Journal Article
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→πAr interaction
Wehn, Paul M., Yang, Song, Grina, Jonas A., Rizzi, James P., Schlachter, Stephen T., Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Czerwinski, Robert M., Ged, Emily L., Huang, Heli, Halfmann, Megan M., Maddie, Melissa A., Morton, Emily R., Olive, Sarah R., Tan, Huiling, Xie, Shanhai, Josey, John A., Wallace, Eli M.
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Journal Article
Crystal Structure and Mechanism of Catalysis of a Pyrazinamidase from Pyrococcus horikoshii
Du, Xinlin, Wang, Weiru, Kim, Rosalind, Yakota, Hisao, Nguyen, Huy, Kim, Sung-Hou
Published in Biochemistry (Easton) (27.11.2001)
Published in Biochemistry (Easton) (27.11.2001)
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Journal Article
Crystal Structure of an Intracellular Protease from Pyrococcus horikoshii at 2-Å Resolution
Du, X, Choi, I G, Kim, R, Wang, W, Jancarik, J, Yokota, H, Kim, S H
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
Published in Proceedings of the National Academy of Sciences - PNAS (19.12.2000)
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Journal Article
The Mechanism of GTP Hydrolysis by Ras Probed by Fourier Transform Infrared Spectroscopy
Du, Xinlin, Frei, Heinz, Kim, Sung-Hou
Published in The Journal of biological chemistry (24.03.2000)
Published in The Journal of biological chemistry (24.03.2000)
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Journal Article
Kinetic Isotope Effects in Ras-Catalyzed GTP Hydrolysis: Evidence for a Loose Transition State
Du, Xinlin, Black, Gavin E., Lecchi, Paolo, Abramson, Fred P., Sprang, Stephen R., Frey, Perry A.
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (15.06.2004)
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Journal Article
Uncoupling Conformational Change from GTP Hydrolysis in a Heterotrimeric G Protein α-Subunit
Thomas, Celestine J., Du, Xinlin, Li, PiLong, Wang, Ying, Ross, Elliott M., Sprang, Stephen R., Bourne, Henry R.
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (18.05.2004)
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Journal Article
The mitochondrial quality control system: a new target for exercise therapeutic intervention in the treatment of brain insulin resistance-induced neurodegeneration in obesity
Cai, Ming, Wan, Jian, Cai, Keren, Li, Shuyao, Du, Xinlin, Song, Haihan, Sun, Wanju, Hu, Jingyun
Published in International Journal of Obesity (01.06.2024)
Published in International Journal of Obesity (01.06.2024)
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Journal Article
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
Cho, Hyejin, Du, Xinlin, Rizzi, James P., Liberzon, Ella, Chakraborty, Abhishek A., Gao, Wenhua, Carvo, Ingrid, Signoretti, Sabina, Bruick, Richard K., Josey, John A., Wallace, Eli M., Kaelin, William G.
Published in Nature (London) (03.11.2016)
Published in Nature (London) (03.11.2016)
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Journal Article
3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma
Xu, Rui, Wang, Keshi, Rizzi, James P, Huang, Heli, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Wehn, Paul M, Yang, Hanbiao, Dixon, Darryl D, Czerwinski, Robert M, Du, Xinlin, Ged, Emily L, Han, Guangzhou, Tan, Huiling, Wong, Tai, Xie, Shanhai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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Journal Article
Navigating the Global Landscape of Exercise Interventions for Knee Osteoarthritis: Exploring Evolving Trends and Emerging Frontiers From a Bibliometric and Visualization Analysis Perspective (2011-2022)
Chen, Qianhong, Cai, Keren, Li, Shuyao, Du, Xinlin, Wang, Fuqiang, Yang, Yu, Cai, Ming
Published in Journal of the American Medical Directors Association (01.11.2024)
Published in Journal of the American Medical Directors Association (01.11.2024)
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Journal Article
Acetate Dependence of Tumors
Comerford, Sarah A., Huang, Zhiguang, Du, Xinlin, Wang, Yun, Cai, Ling, Witkiewicz, Agnes K., Walters, Holly, Tantawy, Mohammed N., Fu, Allie, Manning, H. Charles, Horton, Jay D., Hammer, Robert E., McKnight, Steven L., Tu, Benjamin P.
Published in Cell (18.12.2014)
Published in Cell (18.12.2014)
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Journal Article
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
Wallace, Eli M, Rizzi, James P, Han, Guangzhou, Wehn, Paul M, Cao, Zhaodan, Du, Xinlin, Cheng, Tzuling, Czerwinski, Robert M, Dixon, Darryl D, Goggin, Barry S, Grina, Jonas A, Halfmann, Megan M, Maddie, Melissa A, Olive, Sarah R, Schlachter, Stephen T, Tan, Huiling, Wang, Bin, Wang, Keshi, Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A
Published in Cancer research (Chicago, Ill.) (15.09.2016)
Published in Cancer research (Chicago, Ill.) (15.09.2016)
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Journal Article
Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension
Macias, David, Moore, Stephen, Crosby, Alexi, Southwood, Mark, Du, Xinlin, Tan, Huiling, Xie, Shanhai, Vassallo, Arlette, Wood, Alexander J T, Wallace, Eli M, Cowburn, Andrew S
Published in The European respiratory journal (01.03.2021)
Published in The European respiratory journal (01.03.2021)
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Journal Article
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)
Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro‑1H‑inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)
Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Consistent modeling for device control and simulation in large-scale heterogeneous systems
Jun Luo, Zhigao Ni, Xinlin Du
Published in 2016 IEEE International Conference on Mechatronics and Automation (01.08.2016)
Published in 2016 IEEE International Conference on Mechatronics and Automation (01.08.2016)
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Conference Proceeding