Phase 1 study of ADG126, a novel masked anti-CTLA-4 SAFEbody, that combines tumor-localized activation with strong T reg depletion and soft ligand blocking in patients with advanced solid tumors
Richardson, Gary Edward, Tolcher, Anthony W., Morris, Michelle Frances, de Souza, Paul L., Hamid, Anis, She, Xiaohong, Zhu, Lvyu, Wang, Hongyan, Zheng, Songmao, Liu, Guizhong, Li, Yan, Du, Fangyong Felix, Fischkoff, Steven, Gong, Hua, Zha, Jiping, Luo, Peter
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Abstract A082: A phase 1, first-in-human, dose-escalation study of ADG106, a fully human anti-CD137 agonistic antibody, in subjects with advanced or metastatic solid tumors and/or relapsed/refractory non-Hodgkin lymphoma
Tolcher, Anthony, Karim, Raghad, Rosas, Christina, Liu, Guizhong, Zhu, Yi, Liu, Liming, Du, Felix Fangyong, Luo, Feng Roger, Luo, Peter
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Assessing therapeutic window and dose selection of ADG126 (a masked anti-CTLA-4 SAFEbody): Integrating nonclinical and clinical data using mathematical modeling
Park, John J., Ariyapperuma, Mihitha, Richardson, Gary Edward, Xu, Rui-Hua, Liu, Guizhong, Chen, Xuesong, Skinner, John J., Song, Wenqing, She, Kristine Xiaohong, Zhang, Yanyan, Li, Ai, Wang, Xin, Dai, Zhengxi, Qu, Jiagui, Li, Yan, Du, Fangyong Felix, Xu, Jiangchun, Luo, Peter Peizhi, Zha, Jiping, Zheng, Songmao
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
A phase I, dose-escalation study of ADG106, a fully human anti-CD137 agonistic antibody, in subjects with advanced solid tumors or relapsed/refractory non-Hodgkin lymphoma
Zhang, Li, Zhao, Hongyun, Ma, Yuxiang, Zheng, Xin, Jiang, Ji, Zhang, Yang, Hong, Shaodong, Liu, Guizhong, She, Xiaohong, Ni, Qingjiang, Zhu, Lvyu, Zhu, Yi, Du, Fangyong Felix, Luo, Peter
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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