novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
Massey, Andrew J, Williamson, Douglas S, Browne, Helen, Murray, James B, Dokurno, Pawel, Shaw, Terry, Macias, Alba T, Daniels, Zoe, Geoffroy, Stephanie, Dopson, Melanie, Lavan, Paul, Matassova, Natalia, Francis, Geraint L, Graham, Christopher J, Parsons, Rachel, Wang, Yikang, Padfield, Antony, Comer, Mike, Drysdale, Martin J, Wood, Mike
Published in Cancer chemotherapy and pharmacology (01.08.2010)
Published in Cancer chemotherapy and pharmacology (01.08.2010)
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Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design
Dymock, Brian W, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Massey, Andrew, McDonald, Edward, Hubbard, Roderick E, Surgenor, Allan, Roughley, Stephen D, Webb, Paul, Workman, Paul, Wright, Lisa, Drysdale, Martin J
Published in Journal of medicinal chemistry (30.06.2005)
Published in Journal of medicinal chemistry (30.06.2005)
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Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800
Massey, Andrew J, Schoepfer, Joseph, Brough, Paul A, Brueggen, Josef, Chène, Patrick, Drysdale, Martin J, Pfaar, Ulrike, Radimerski, Thomas, Ruetz, Stephan, Schweitzer, Alain, Wood, Mike, Garcia-Echeverria, Carlos, Jensen, Michael Rugaard
Published in Molecular cancer therapeutics (01.04.2010)
Published in Molecular cancer therapeutics (01.04.2010)
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Structure-based Drug Design Targeting an Inactive RNA Conformation: Exploiting the Flexibility of HIV-1 TAR RNA
Murchie, Alastair I.H., Davis, Ben, Isel, Catherine, Afshar, Mohammad, Drysdale, Martin J., Bower, Justin, Potter, Andrew J., Starkey, Ian D., Swarbrick, Terry M., Mirza, Shabana, Prescott, Catherine D., Vaglio, Philippe, Aboul-ela, Fareed, Karn, Jonathan
Published in Journal of molecular biology (20.02.2004)
Published in Journal of molecular biology (20.02.2004)
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Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction
McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
Smith, Nicola F, Hayes, Angela, James, Karen, Nutley, Bernard P, McDonald, Edward, Henley, Alan, Dymock, Brian, Drysdale, Martin J, Raynaud, Florence I, Workman, Paul
Published in Molecular cancer therapeutics (01.06.2006)
Published in Molecular cancer therapeutics (01.06.2006)
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4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
Brough, Paul A, Aherne, Wynne, Barril, Xavier, Borgognoni, Jenifer, Boxall, Kathy, Cansfield, Julie E, Cheung, Kwai-Ming J, Collins, Ian, Davies, Nicholas G. M, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Finch, Harry, Fink, Alexandra, Hayes, Angela, Howes, Robert, Hubbard, Roderick E, James, Karen, Jordan, Allan M, Lockie, Andrea, Martins, Vanessa, Massey, Andrew, Matthews, Thomas P, McDonald, Edward, Northfield, Christopher J, Pearl, Laurence H, Prodromou, Chrisostomos, Ray, Stuart, Raynaud, Florence I, Roughley, Stephen D, Sharp, Swee Y, Surgenor, Allan, Walmsley, D. Lee, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa
Published in Journal of medicinal chemistry (24.01.2008)
Published in Journal of medicinal chemistry (24.01.2008)
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Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design
Williamson, Douglas S, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J, Foloppe, Nicolas, Francis, Geraint L, Graham, Christopher J, Howes, Rob, Macias, Alba T, Murray, James B, Parsons, Rachel, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Wood, Mike, Massey, Andrew J
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Unbekandt, Mathieu, Belshaw, Simone, Bower, Justin, Clarke, Maeve, Cordes, Jacqueline, Crighton, Diane, Croft, Daniel R, Drysdale, Martin J, Garnett, Mathew J, Gill, Kathryn, Gray, Christopher, Greenhalgh, David A, Hall, James A M, Konczal, Jennifer, Lilla, Sergio, McArthur, Duncan, McConnell, Patricia, McDonald, Laura, McGarry, Lynn, McKinnon, Heather, McMenemy, Carol, Mezna, Mokdad, Morrice, Nicolas A, Munro, June, Naylor, Gregory, Rath, Nicola, Schüttelkopf, Alexander W, Sime, Mairi, Olson, Michael F
Published in Cancer research (Chicago, Ill.) (15.04.2018)
Published in Cancer research (Chicago, Ill.) (15.04.2018)
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NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
Jensen, Michael Rugaard, Schoepfer, Joseph, Radimerski, Thomas, Massey, Andrew, Guy, Chantale T, Brueggen, Josef, Quadt, Cornelia, Buckler, Alan, Cozens, Robert, Drysdale, Martin J, Garcia-Echeverria, Carlos, Chène, Patrick
Published in Breast cancer research : BCR (01.01.2008)
Published in Breast cancer research : BCR (01.01.2008)
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Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity
Macias, Alba T, Williamson, Douglas S, Allen, Nicola, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J, Francis, Geraint L, Graham, Christopher J, Howes, Rob, Matassova, Natalia, Murray, James B, Parsons, Rachel, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Wood, Mike, Massey, Andrew J
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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Discovery and development of pyrazole-scaffold Hsp90 inhibitors
McDonald, Edward, Jones, Keith, Brough, Paul A, Drysdale, Martin J, Workman, Paul
Published in Current topics in medicinal chemistry (01.06.2006)
Published in Current topics in medicinal chemistry (01.06.2006)
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The SeeDs approach: integrating fragments into drug discovery
Hubbard, Roderick E, Davis, Ben, Chen, Ijen, Drysdale, Martin J
Published in Current topics in medicinal chemistry (01.08.2007)
Published in Current topics in medicinal chemistry (01.08.2007)
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Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization
Davies, Nicholas G.M., Browne, Helen, Davis, Ben, Drysdale, Martin J., Foloppe, Nicolas, Geoffrey, Stephanie, Gibbons, Ben, Hart, Terance, Hubbard, Roderick, Jensen, Michael Rugaard, Mansell, Howard, Massey, Andrew, Matassova, Natalia, Moore, Jonathan D., Murray, James, Pratt, Robert, Ray, Stuart, Robertson, Alan, Roughley, Stephen D., Schoepfer, Joseph, Scriven, Kirsten, Simmonite, Heather, Stokes, Stephen, Surgenor, Allan, Webb, Paul, Wood, Mike, Wright, Lisa, Brough, Paul
Published in Bioorganic & medicinal chemistry (15.11.2012)
Published in Bioorganic & medicinal chemistry (15.11.2012)
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4-Amino derivatives of the Hsp90 inhibitor CCT018159
Barril, Xavier, Beswick, Mandy C., Collier, Adam, Drysdale, Martin J., Dymock, Brian W., Fink, Alexandra, Grant, Kate, Howes, Robert, Jordan, Allan M., Massey, Andrew, Surgenor, Allan, Wayne, Joanne, Workman, Paul, Wright, Lisa
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping
Richardson, Christine M., Nunns, Claire L., Williamson, Douglas S., Parratt, Martin J., Dokurno, Pawel, Howes, Rob, Borgognoni, Jenifer, Drysdale, Martin J., Finch, Harry, Hubbard, Roderick E., Jackson, Philip S., Kierstan, Peter, Lentzen, Georg, Moore, Jonathan D., Murray, James B., Simmonite, Heather, Surgenor, Allan E., Torrance, Christopher J.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone
Brough, Paul A., Barril, Xavier, Beswick, Mandy, Dymock, Brian W., Drysdale, Martin J., Wright, Lisa, Grant, Kate, Massey, Andrew, Surgenor, Allan, Workman, Paul
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine
YOUNG, R. J, BEAMS, R. M, FRENCH, C, HODGSON, S. T, HODSON, H. F, KLEANTHOUS, S, RIDER, P, SANDERS, D, SAWYER, D. A, SCOTT, K. J, SHEARER, B. G, STOCKER, R, CARTER, K, SMITH, S, TACKLEY, M. C, KNOWLES, R. G, CLARK, H. A. R, COE, D. M, CHAMBERS, C. L, DAVIES, P. I, DAWSON, J, DRYSDALE, M. J, FRANZMAN, K. W
Published in Bioorganic & medicinal chemistry letters (20.03.2000)
Published in Bioorganic & medicinal chemistry letters (20.03.2000)
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