novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
Massey, Andrew J, Williamson, Douglas S, Browne, Helen, Murray, James B, Dokurno, Pawel, Shaw, Terry, Macias, Alba T, Daniels, Zoe, Geoffroy, Stephanie, Dopson, Melanie, Lavan, Paul, Matassova, Natalia, Francis, Geraint L, Graham, Christopher J, Parsons, Rachel, Wang, Yikang, Padfield, Antony, Comer, Mike, Drysdale, Martin J, Wood, Mike
Published in Cancer chemotherapy and pharmacology (01.08.2010)
Published in Cancer chemotherapy and pharmacology (01.08.2010)
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Journal Article
Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design
Dymock, Brian W, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Massey, Andrew, McDonald, Edward, Hubbard, Roderick E, Surgenor, Allan, Roughley, Stephen D, Webb, Paul, Workman, Paul, Wright, Lisa, Drysdale, Martin J
Published in Journal of medicinal chemistry (30.06.2005)
Published in Journal of medicinal chemistry (30.06.2005)
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Journal Article
Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells
Drysdale, Alison J, Ryan, Duncan, Pertwee, Roger G, Platt, Bettina
Published in Neuropharmacology (01.04.2006)
Published in Neuropharmacology (01.04.2006)
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Journal Article
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800
Massey, Andrew J, Schoepfer, Joseph, Brough, Paul A, Brueggen, Josef, Chène, Patrick, Drysdale, Martin J, Pfaar, Ulrike, Radimerski, Thomas, Ruetz, Stephan, Schweitzer, Alain, Wood, Mike, Garcia-Echeverria, Carlos, Jensen, Michael Rugaard
Published in Molecular cancer therapeutics (01.04.2010)
Published in Molecular cancer therapeutics (01.04.2010)
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Journal Article
Structure-based Drug Design Targeting an Inactive RNA Conformation: Exploiting the Flexibility of HIV-1 TAR RNA
Murchie, Alastair I.H., Davis, Ben, Isel, Catherine, Afshar, Mohammad, Drysdale, Martin J., Bower, Justin, Potter, Andrew J., Starkey, Ian D., Swarbrick, Terry M., Mirza, Shabana, Prescott, Catherine D., Vaglio, Philippe, Aboul-ela, Fareed, Karn, Jonathan
Published in Journal of molecular biology (20.02.2004)
Published in Journal of molecular biology (20.02.2004)
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Journal Article
4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
Brough, Paul A, Aherne, Wynne, Barril, Xavier, Borgognoni, Jenifer, Boxall, Kathy, Cansfield, Julie E, Cheung, Kwai-Ming J, Collins, Ian, Davies, Nicholas G. M, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Finch, Harry, Fink, Alexandra, Hayes, Angela, Howes, Robert, Hubbard, Roderick E, James, Karen, Jordan, Allan M, Lockie, Andrea, Martins, Vanessa, Massey, Andrew, Matthews, Thomas P, McDonald, Edward, Northfield, Christopher J, Pearl, Laurence H, Prodromou, Chrisostomos, Ray, Stuart, Raynaud, Florence I, Roughley, Stephen D, Sharp, Swee Y, Surgenor, Allan, Walmsley, D. Lee, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa
Published in Journal of medicinal chemistry (24.01.2008)
Published in Journal of medicinal chemistry (24.01.2008)
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Journal Article
Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia
Ryan, Duncan, Drysdale, Alison J., Pertwee, Roger G., Platt, Bettina
Published in Neuroscience letters (20.11.2006)
Published in Neuroscience letters (20.11.2006)
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Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels
Ryan, Duncan, Drysdale, Alison J, Lafourcade, Carlos, Pertwee, Roger G, Platt, Bettina
Published in The Journal of neuroscience (18.02.2009)
Published in The Journal of neuroscience (18.02.2009)
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Journal Article
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors
Smith, Nicola F, Hayes, Angela, James, Karen, Nutley, Bernard P, McDonald, Edward, Henley, Alan, Dymock, Brian, Drysdale, Martin J, Raynaud, Florence I, Workman, Paul
Published in Molecular cancer therapeutics (01.06.2006)
Published in Molecular cancer therapeutics (01.06.2006)
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Journal Article
4-Amino derivatives of the Hsp90 inhibitor CCT018159
Barril, Xavier, Beswick, Mandy C., Collier, Adam, Drysdale, Martin J., Dymock, Brian W., Fink, Alexandra, Grant, Kate, Howes, Robert, Jordan, Allan M., Massey, Andrew, Surgenor, Allan, Wayne, Joanne, Workman, Paul, Wright, Lisa
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
A fluorescence polarization assay for inhibitors of Hsp90
Howes, R., Barril, X., Dymock, B.W., Grant, K., Northfield, C.J., Robertson, A.G.S., Surgenor, A., Wayne, J., Wright, L., James, K., Matthews, T., Cheung, K.-M., McDonald, E., Workman, P., Drysdale, M.J.
Published in Analytical biochemistry (15.03.2006)
Published in Analytical biochemistry (15.03.2006)
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Journal Article
Discovery of a First-in-Class Inhibitor of the PRMT5–Substrate Adaptor Interaction
McKinney, David C, McMillan, Brian J, Ranaghan, Matthew J, Moroco, Jamie A, Brousseau, Merissa, Mullin-Bernstein, Zachary, O’Keefe, Meghan, McCarren, Patrick, Mesleh, Michael F, Mulvaney, Kathleen M, Robinson, Foxy, Singh, Ritu, Bajrami, Besnik, Wagner, Florence F, Hilgraf, Robert, Drysdale, Martin J, Campbell, Arthur J, Skepner, Adam, Timm, David E, Porter, Dale, Kaushik, Virendar K, Sellers, William R, Ianari, Alessandra
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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The use of transient evoked otoacoustic emissions as a hearing screen following grommet insertion
Dale, O T, McCann, L J, Thio, D, Wells, S C, Drysdale, A J
Published in Journal of laryngology and otology (01.07.2011)
Published in Journal of laryngology and otology (01.07.2011)
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Journal Article
Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design
Williamson, Douglas S, Borgognoni, Jenifer, Clay, Alexandra, Daniels, Zoe, Dokurno, Pawel, Drysdale, Martin J, Foloppe, Nicolas, Francis, Geraint L, Graham, Christopher J, Howes, Rob, Macias, Alba T, Murray, James B, Parsons, Rachel, Shaw, Terry, Surgenor, Allan E, Terry, Lindsey, Wang, Yikang, Wood, Mike, Massey, Andrew J
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Journal Article
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Unbekandt, Mathieu, Belshaw, Simone, Bower, Justin, Clarke, Maeve, Cordes, Jacqueline, Crighton, Diane, Croft, Daniel R, Drysdale, Martin J, Garnett, Mathew J, Gill, Kathryn, Gray, Christopher, Greenhalgh, David A, Hall, James A M, Konczal, Jennifer, Lilla, Sergio, McArthur, Duncan, McConnell, Patricia, McDonald, Laura, McGarry, Lynn, McKinnon, Heather, McMenemy, Carol, Mezna, Mokdad, Morrice, Nicolas A, Munro, June, Naylor, Gregory, Rath, Nicola, Schüttelkopf, Alexander W, Sime, Mairi, Olson, Michael F
Published in Cancer research (Chicago, Ill.) (15.04.2018)
Published in Cancer research (Chicago, Ill.) (15.04.2018)
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