Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation
Hubbard, Troy D, Murray, Iain A, Perdew, Gary H
Published in Drug metabolism and disposition (01.10.2015)
Published in Drug metabolism and disposition (01.10.2015)
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Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification
Sager, Jennifer E, Yu, Jingjing, Ragueneau-Majlessi, Isabelle, Isoherranen, Nina
Published in Drug metabolism and disposition (01.11.2015)
Published in Drug metabolism and disposition (01.11.2015)
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Journal Article
Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease
Fennema, Diede, Phillips, Ian R, Shephard, Elizabeth A
Published in Drug metabolism and disposition (01.11.2016)
Published in Drug metabolism and disposition (01.11.2016)
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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
Eng, Heather, Dantonio, Alyssa L, Kadar, Eugene P, Obach, R Scott, Di, Li, Lin, Jian, Patel, Nandini C, Boras, Britton, Walker, Gregory S, Novak, Jonathan J, Kimoto, Emi, Singh, Ravi Shankar P, Kalgutkar, Amit S
Published in Drug metabolism and disposition (01.05.2022)
Published in Drug metabolism and disposition (01.05.2022)
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Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities
Ohtsuki, Sumio, Schaefer, Olaf, Kawakami, Hirotaka, Inoue, Tae, Liehner, Stephanie, Saito, Asami, Ishiguro, Naoki, Kishimoto, Wataru, Ludwig-Schwellinger, Eva, Ebner, Thomas, Terasaki, Tetsuya
Published in Drug metabolism and disposition (01.01.2012)
Published in Drug metabolism and disposition (01.01.2012)
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Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite
KAZUI, Miho, NISHIYA, Yumi, ISHIZUKA, Tomoko, HAGIHARA, Katsunobu, FARID, Nagy A, OKAZAKI, Osamu, IKEDA, Toshihiko, KURIHARA, Atsushi
Published in Drug metabolism and disposition (01.01.2010)
Published in Drug metabolism and disposition (01.01.2010)
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Journal Article
Gestational Age-Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics
Anoshchenko, Olena, Prasad, Bhagwat, Neradugomma, Naveen K, Wang, Joanne, Mao, Qingcheng, Unadkat, Jashvant D
Published in Drug metabolism and disposition (01.09.2020)
Published in Drug metabolism and disposition (01.09.2020)
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Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?
Callaghan, Richard, Luk, Frederick, Bebawy, Mary
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
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Journal Article
Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
Raub, Thomas J, Wishart, Graham N, Kulanthaivel, Palaniappan, Staton, Brian A, Ajamie, Rose T, Sawada, Geri A, Gelbert, Lawrence M, Shannon, Harlan E, Sanchez-Martinez, Concepcion, De Dios, Alfonso
Published in Drug metabolism and disposition (01.09.2015)
Published in Drug metabolism and disposition (01.09.2015)
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Journal Article
Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites
Guo, Yukuang, Crnkovic, Camila Manoel, Won, Kyoung-Jae, Yang, Xiaotong, Lee, John Richard, Orjala, Jimmy, Lee, Hyunwoo, Jeong, Hyunyoung
Published in Drug metabolism and disposition (01.03.2019)
Published in Drug metabolism and disposition (01.03.2019)
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Journal Article
The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans
Dowty, Martin E, Lin, Jinyan, Ryder, Tim F, Wang, Weiwei, Walker, Gregory S, Vaz, Alfin, Chan, Gary L, Krishnaswami, Sriram, Prakash, Chandra
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities
Zhang, Donglu, Hop, Cornelis E C A, Patilea-Vrana, Gabriela, Gampa, Gautham, Seneviratne, Herana Kamal, Unadkat, Jashvant D, Kenny, Jane R, Nagapudi, Karthik, Di, Li, Zhou, Lian, Zak, Mark, Wright, Matthew R, Bumpus, Namandjé N, Zang, Richard, Liu, Xingrong, Lai, Yurong, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury
Bell, Catherine C, Lauschke, Volker M, Vorrink, Sabine U, Palmgren, Henrik, Duffin, Rodger, Andersson, Tommy B, Ingelman-Sundberg, Magnus
Published in Drug metabolism and disposition (01.04.2017)
Published in Drug metabolism and disposition (01.04.2017)
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Absorption, Distribution, Metabolism, and Excretion of US Food and Drug Administration-Approved Antisense Oligonucleotide Drugs
Migliorati, Julia M, Liu, Sunna, Liu, Anna, Gogate, Anagha, Nair, Sreenidhi, Bahal, Raman, Rasmussen, Theodore P, Manautou, José E, Zhong, Xiao-Bo
Published in Drug metabolism and disposition (01.06.2022)
Published in Drug metabolism and disposition (01.06.2022)
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Journal Article
Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation
Tian, Yuan, Cai, Jingwei, Gui, Wei, Nichols, Robert G, Koo, Imhoi, Zhang, Jingtao, Anitha, Mallappa, Patterson, Andrew D
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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