Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells
Usenovic, Marija, Niroomand, Shahriar, Drolet, Robert E, Yao, Lihang, Gaspar, Renee C, Hatcher, Nathan G, Schachter, Joel, Renger, John J, Parmentier-Batteur, Sophie
Published in The Journal of neuroscience (21.10.2015)
Published in The Journal of neuroscience (21.10.2015)
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TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation
Jinn, Sarah, Drolet, Robert E., Cramer, Paige E., Wong, Andus Hon-Kit, Toolan, Dawn M., Gretzula, Cheryl A., Voleti, Bhavya, Vassileva, Galya, Disa, Jyoti, Tadin-Strapps, Marija, Stone, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (28.02.2017)
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Journal Article
A highly reproducible rotenone model of Parkinson's disease
Cannon, Jason R, Tapias, Victor, Na, Hye Mee, Honick, Anthony S, Drolet, Robert E, Greenamyre, J. Timothy
Published in Neurobiology of disease (01.05.2009)
Published in Neurobiology of disease (01.05.2009)
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Journal Article
Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease
Jinn, Sarah, Blauwendraat, Cornelis, Toolan, Dawn, Gretzula, Cheryl A, Drolet, Robert E, Smith, Sean, Nalls, Mike A, Marcus, Jacob, Singleton, Andrew B, Stone, David J
Published in Human molecular genetics (01.10.2019)
Published in Human molecular genetics (01.10.2019)
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Journal Article
Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
Drolet, Robert E, Cannon, Jason R, Montero, Laura, Greenamyre, J. Timothy
Published in Neurobiology of disease (01.10.2009)
Published in Neurobiology of disease (01.10.2009)
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Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model
Polinski, Nicole K, Martinez, Terina N, Gorodinsky, Alexander, Gareus, Ralph, Sasner, Michael, Herberth, Mark, Switzer, Robert, Ahmad, Syed O, Cosden, Mali, Kandebo, Monika, Drolet, Robert E, Buckett, Peter D, Shan, Weisong, Chen, Yi, Pellegrino, Lee J, Ellsworth, Gregory D, Dungan, Leo B, Hirst, Warren D, Clark, Sean W, Dave, Kuldip D
Published in PloS one (09.06.2021)
Published in PloS one (09.06.2021)
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LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease
Rocha, Emily M., De Miranda, Briana R., Castro, Sandra, Drolet, Robert, Hatcher, Nathan G., Yao, Lihang, Smith, Sean M., Keeney, Matthew T., Di Maio, Roberto, Kofler, Julia, Hastings, Teresa G., Greenamyre, J. Timothy
Published in Neurobiology of disease (01.02.2020)
Published in Neurobiology of disease (01.02.2020)
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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy
Cosden, Mali, Jinn, Sarah, Yao, Lihang, Gretzula, Cheryl A., Kandebo, Monika, Toolan, Dawn, Hatcher, Nathan G., Ma, Lei, Lemaire, Wei, Adam, Gregory C., Burlein, Christine, Minnick, Christina, Flick, Rose, Watt, Marla L., Mulhearn, James, Fraley, Mark, Drolet, Robert E., Marcus, Jacob N., Smith, Sean M.
Published in Neurobiology of disease (01.11.2021)
Published in Neurobiology of disease (01.11.2021)
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Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
Scott, Jack D, DeMong, Duane E, Greshock, Thomas J, Basu, Kallol, Dai, Xing, Harris, Joel, Hruza, Alan, Li, Sarah W, Lin, Sue-Ing, Liu, Hong, Macala, Megan K, Hu, Zhiyong, Mei, Hong, Zhang, Honglu, Walsh, Paul, Poirier, Marc, Shi, Zhi-Cai, Xiao, Li, Agnihotri, Gautam, Baptista, Marco A. S, Columbus, John, Fell, Matthew J, Hyde, Lynn A, Kuvelkar, Reshma, Lin, Yinghui, Mirescu, Christian, Morrow, John A, Yin, Zhizhang, Zhang, Xiaoping, Zhou, Xiaoping, Chang, Ronald K, Embrey, Mark W, Sanders, John M, Tiscia, Heather E, Drolet, Robert E, Kern, Jonathan T, Sur, Sylvie M, Renger, John J, Bilodeau, Mark T, Kennedy, Matthew E, Parker, Eric M, Stamford, Andrew W, Nargund, Ravi, McCauley, John A, Miller, Michael W
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Non‐motor parkinsonian pathology in aging A53T α‐Synuclein mice is associated with progressive synucleinopathy and altered enzymatic function
Farrell, Kaitlin F., Krishnamachari, Sesha, Villanueva, Ernesto, Lou, Haiyan, Alerte, Tshianda N. M., Peet, Eloise, Drolet, Robert E., Perez, Ruth G.
Published in Journal of neurochemistry (01.02.2014)
Published in Journal of neurochemistry (01.02.2014)
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Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections
Loughran, H. Marie, Schirripa, Kathy M., Roecker, Anthony J., Breslin, Michael J., Tong, Ling, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Newman, Justin A., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.
Published in ACS medicinal chemistry letters (11.01.2024)
Published in ACS medicinal chemistry letters (11.01.2024)
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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator
Rudd, Michael T., Manley, Peter J., Hanney, Barbara, Meng, Zhaoyang, Shu, Youheng, de Leon, Pablo, Frie, Jessica L., Han, Yongxin, Wai, Jenny Miu-Chun, Yang, Zhi-Qiang, Perkins, James J., Hurzy, Danielle M., Manikowski, Jesse J., Zhu, Hong, Bungard, Christopher J., Converso, Antonella, Meissner, Robert S., Cosden, Mali L., Hayashi, Ikuo, Ma, Lei, O’Brien, Julie, Uebele, Victor N., Schachter, Joel B., Bhandari, Neetesh, Ward, Gwendolyn J., Fillgrove, Kerry L., Lu, Bing, Liang, Yuexia, Dubost, David C., Puri, Vanita, Eddins, Donnie M., Vardigan, Joshua D., Drolet, Robert E., Kern, Jonathan T., Uslaner, Jason M.
Published in ACS medicinal chemistry letters (10.08.2023)
Published in ACS medicinal chemistry letters (10.08.2023)
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Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson’s Disease
Roecker, Anthony J., Schirripa, Kathy M., Loughran, H. Marie, Tong, Ling, Liang, Tao, Fillgrove, Kerry L., Kuo, Yuhsin, Bleasby, Kelly, Collier, Hannah, Altman, Michael D., Ford, Melissa C., Drolet, Robert E., Cosden, Mali, Jinn, Sarah, Hatcher, Nathan G., Yao, Lihang, Kandebo, Monika, Vardigan, Joshua D., Flick, Rosemarie B., Liu, Xiaomei, Minnick, Christina, Price, Laura A., Watt, Marla L., Lemaire, Wei, Burlein, Christine, Adam, Gregory C., Austin, Lauren A., Marcus, Jacob N., Smith, Sean M., Fraley, Mark E.
Published in ACS medicinal chemistry letters (09.02.2023)
Published in ACS medicinal chemistry letters (09.02.2023)
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Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors
Greshock, Thomas J., Sanders, John M., Drolet, Robert E., Rajapakse, Hemaka A., Chang, Ronald K., Kim, Boyoung, Rada, Vanessa L., Tiscia, Heather E., Su, Hua, Lai, Ming-Tain, Sur, Sylvie M., Sanchez, Rosa I., Bilodeau, Mark T., Renger, John J., Kern, Jonathan T., McCauley, John A.
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
Published in Bioorganic & medicinal chemistry letters (01.06.2016)
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Effects of Sildenafil on Nigrostriatal Dopamine Neurons in a Murine Model of Parkinson's Disease
Janis, Kelly L., Brennan, Ryan T., Drolet, Robert E., Behrouz, Bahareh, Kaufman, Sarah K., Lookingland, Keith J., Goudreau, John L.
Published in Journal of Alzheimer's disease (01.09.2008)
Published in Journal of Alzheimer's disease (01.09.2008)
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