Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties
Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Zheng, Guo Zhu, Perner, Richard J, Didomenico, Stanley, Koenig, John R, Turner, Sean, Jinkerson, Tammie, Drizin, Irene, Hannick, Steven M, Macri, Bryan S, McDonald, Heath A, Honore, Prisca, Wismer, Carol T, Marsh, Kennan C, Wetter, Jill, Stewart, Kent D, Oie, Tetsuro, Jarvis, Michael F, Surowy, Carol S, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (10.02.2005)
Published in Journal of medicinal chemistry (10.02.2005)
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Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain
Kort, Michael E, Drizin, Irene, Gregg, Robert J, Scanio, Marc J. C, Shi, Lei, Gross, Michael F, Atkinson, Robert N, Johnson, Matthew S, Pacofsky, Gregory J, Thomas, James B, Carroll, William A, Krambis, Michael J, Liu, Dong, Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Mikusa, Joseph P, Zhong, Chengmin, Joshi, Shailen, Honore, Prisca, Roeloffs, Rosemarie, Marsh, Kennan C, Murray, Bernard P, Liu, Jinrong, Werness, Stephen, Faltynek, Connie R, Krafte, Douglas S, Jarvis, Michael F, Chapman, Mark L, Marron, Brian E
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists
Perner, Richard J, DiDomenico, Stanley, Koenig, John R, Gomtsyan, Arthur, Bayburt, Erol K, Schmidt, Robert G, Drizin, Irene, Zheng, Guo Zhu, Turner, Sean C, Jinkerson, Tammie, Brown, Brian S, Keddy, Ryan G, Lukin, Kurill, McDonald, Heath A, Honore, Prisca, Mikusa, Joe, Marsh, Kennan C, Wetter, Jill M, St. George, Karen, Jarvis, Michael F, Faltynek, Connie R, Lee, Chih-Hung
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na sub(v)1.8 sodium channel with efficacy in a model of neuropathic pain
Scanio, MJ, Shi, L, Drizin, I, Gregg, R J, Atkinson, R N, Thomas, J B, Johnson, MS, Chapman, M L, Liu, D, Krambis, MJ, Liu, Y, Shieh, C C, Zhang, X, Simler, G H, Joshi, S, Honore, P, Marsh, K C, Knox, A, Werness, S, Antonio, B, Krafte, D S, Jarvis, M F, Faltynek, C R, Marron, B E, Kort, ME
Published in Bioorganic & medicinal chemistry (15.11.2010)
Published in Bioorganic & medicinal chemistry (15.11.2010)
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Journal Article
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain
Drizin, Irene, Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Carroll, William A., Marron, Brian E., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhu, Chang Z., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Roeloffs, Rosemarie, Werness, Stephen, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Journal Article
Structure-activity studies for a novel series of tricyclic substituted hexahydrobenz[e]isoindole alpha(1A) adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia (BPH)
Meyer, MD, Altenbach, RJ, Basha, FZ, Carroll, WA, Condon, S, Elmore, SW, Kerwin, JF, Sippy, KB, Tietje, K, Wendt, MD, Hancock, AA, Brune, ME, Buckner, SA, Drizin
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Journal Article
Structure−Activity Studies for a Novel Series of Bicyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia
Meyer, Michael D, Altenbach, Robert J, Bai, Hao, Basha, Fatima Z, Carroll, William A, Kerwin, James F, Lebold, Suzanne A, Lee, Edmund, Pratt, John K, Sippy, Kevin B, Tietje, Karin, Wendt, Michael D, Brune, Michael E, Buckner, Steven A, Hancock, Arthur A, Drizin, Irene
Published in Journal of medicinal chemistry (07.06.2001)
Published in Journal of medicinal chemistry (07.06.2001)
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Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia
Meyer, M D, Altenbach, R J, Bai, H, Basha, F Z, Carroll, W A, Kerwin, Jr, J F, Lebold, S A, Lee, E, Pratt, J K, Sippy, K B, Tietje, K, Wendt, M D, Brune, M E, Buckner, S A, Hancock, A A, Drizin, I
Published in Journal of medicinal chemistry (07.06.2001)
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Published in Journal of medicinal chemistry (07.06.2001)
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Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e]isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (A-131701): A uroselective alpha(1A) adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia
Meyer, MD, Altenbach, RJ, Basha, FZ, Carroll, WA, Drizin, Elmore, SW, Ehrlich, PP, Lebold, SA, Tietje, K, Sippy, KB, Wendt, MD, Plata, DJ, Plagge, F, Buckner, SA, Brune, ME, Hancock, AA, Kerwin, JF
Published in Journal of medicinal chemistry (26.09.1997)
Published in Journal of medicinal chemistry (26.09.1997)
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Journal Article
Structure−Activity Studies for a Novel Series of Tricyclic Substituted Hexahydrobenz[e]isoindole α1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia (BPH)
Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Condon, Stephen, Elmore, Steven W, Kerwin, James F, Sippy, Kevin B, Tietje, Karin, Wendt, Michael D, Hancock, Arthur A, Brune, Michael E, Buckner, Steven A, Drizin, Irene
Published in Journal of medicinal chemistry (20.04.2000)
Published in Journal of medicinal chemistry (20.04.2000)
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Journal Article
Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia
Meyer, M D, Altenbach, R J, Basha, F Z, Carroll, W A, Drizin, I, Elmore, S W, Ehrlich, P P, Lebold, S A, Tietje, K, Sippy, K B, Wendt, M D, Plata, D J, Plagge, F, Buckner, S A, Brune, M E, Hancock, A A, Kerwin, Jr, J F
Published in Journal of medicinal chemistry (26.09.1997)
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Published in Journal of medicinal chemistry (26.09.1997)
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Synthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701): A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia
Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Drizin, Irene, Elmore, Steven W, Ehrlich, Paul P, Lebold, Suzanne A, Tietje, Karin, Sippy, Kevin B, Wendt, Michael D, Plata, Daniel J, Plagge, Fred, Buckner, Steven A, Brune, Michael E, Hancock, Arthur A, Kerwin, James F
Published in Journal of medicinal chemistry (26.09.1997)
Published in Journal of medicinal chemistry (26.09.1997)
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2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists
Winn, Martin, De, Biswanath, Zydowsky, Thomas M, Altenbach, Robert J, Basha, Fatima Z, Boyd, Steven A, Brune, Michael E, Buckner, Steven A, Crowell, DeAnne
Published in Journal of medicinal chemistry (03.09.1993)
Published in Journal of medicinal chemistry (03.09.1993)
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Year of Publication 14.10.2014
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Year of Publication 14.10.2014
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GFESSER, GREGORY, A, MORTELL, KATHLEEN, DAANEN, JEROME, F, WOLLER, KEVIN, R, DRIZIN, IRENE, I, LIU, HUAQING, VOIGHT, ERIC, A, KORT, MICHAEL, E, GOMTSYAN, ARTHUR, KYM, PHILIP, R, SHRESTHA, ANURUPA
Year of Publication 27.06.2013
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Year of Publication 27.06.2013
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TRPV1 Antagonists
WOLLER KEVIN R, LIU HUAQING, KYM PHILIP R, KORT MICHAEL E, SHRESTHA ANURUPA, GOMTSYAN ARTHUR, MORTELL KATHLEEN H, GFESSER GREGORY A, DAANEN JEROME F, DRIZIN IRENE I, VOIGHT ERIC A
Year of Publication 20.06.2013
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Year of Publication 20.06.2013
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