The signalling conformation of the insulin receptor ectodomain
Weis, Felix, Menting, John G., Margetts, Mai B., Chan, Shu Jin, Xu, Yibin, Tennagels, Norbert, Wohlfart, Paulus, Langer, Thomas, Müller, Christoph W., Dreyer, Matthias K., Lawrence, Michael C.
Published in Nature communications (24.10.2018)
Published in Nature communications (24.10.2018)
Get full text
Journal Article
Estimation of Protein–Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations
Wolf, Steffen, Amaral, Marta, Lowinski, Maryse, Vallée, Francois, Musil, Djordje, Güldenhaupt, Jörn, Dreyer, Matthias K, Bomke, Jörg, Frech, Matthias, Schlitter, Jürgen, Gerwert, Klaus
Published in Journal of chemical information and modeling (23.12.2019)
Published in Journal of chemical information and modeling (23.12.2019)
Get full text
Journal Article
Crystal structure of the BMP-2-BRIA ectodomain complex
Dreyer, Matthias K, Kirsch, Thomas, Sebald, Walter
Published in Nature structural & molecular biology (01.06.2000)
Published in Nature structural & molecular biology (01.06.2000)
Get full text
Journal Article
Estimation of Drug-Target Residence Times by τ‑Random Acceleration Molecular Dynamics Simulations
Kokh, Daria B, Amaral, Marta, Bomke, Joerg, Grädler, Ulrich, Musil, Djordje, Buchstaller, Hans-Peter, Dreyer, Matthias K, Frech, Matthias, Lowinski, Maryse, Vallee, Francois, Bianciotto, Marc, Rak, Alexey, Wade, Rebecca C
Published in Journal of chemical theory and computation (10.07.2018)
Published in Journal of chemical theory and computation (10.07.2018)
Get full text
Journal Article
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis
Halland, Nis, Schmidt, Friedemann, Weiss, Tilo, Li, Ziyu, Czech, Jorg, Saas, Joachim, Ding-Pfennigdorff, Danping, Dreyer, Matthias K., Strubing, Carsten, Nazare, Marc
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
Get full text
Journal Article
Kinetics of human cannabinoid 1 (CB1) receptor antagonists: Structure-kinetics relationships (SKR) and implications for insurmountable antagonism
Xia, Lizi, de Vries, Henk, Yang, Xue, Lenselink, Eelke B., Kyrizaki, Athina, Barth, Francis, Louvel, Julien, Dreyer, Matthias K., van der Es, Daan, IJzerman, Adriaan P., Heitman, Laura H.
Published in Biochemical pharmacology (01.05.2018)
Published in Biochemical pharmacology (01.05.2018)
Get full text
Journal Article
Accounting for Conformational Variability in Protein–Ligand Docking with NMR-Guided Rescoring
Skjærven, Lars, Codutti, Luca, Angelini, Andrea, Grimaldi, Manuela, Latek, Dorota, Monecke, Peter, Dreyer, Matthias K, Carlomagno, Teresa
Published in Journal of the American Chemical Society (17.04.2013)
Published in Journal of the American Chemical Society (17.04.2013)
Get full text
Journal Article
Crystal Structure of MJ1247 Protein from M. jannaschii at 2.0 Å Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate Isomerase
Martinez-Cruz, Luis Alfonso, Dreyer, Matthias K, Boisvert, David C, Yokota, Hisao, Martinez-Chantar, Maria Luz, Kim, Rosalind, Kim, Sung-Hou
Published in Structure (London) (01.02.2002)
Published in Structure (London) (01.02.2002)
Get full text
Journal Article
Rational design of potent GSK3β inhibitors with selectivity for Cdk1 and Cdk2
Lesuisse, Dominique, Dutruc-Rosset, Gilles, Tiraboschi, Gilles, Dreyer, Matthias K., Maignan, Sébastien, Chevalier, Alain, Halley, Frank, Bertrand, Philippe, Burgevin, Marie-Claude, Quarteronet, Dominique, Rooney, Thomas
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Get full text
Journal Article
Influence of Heparin Mimetics on Assembly of the FGF·FGFR4 Signaling Complex
Saxena, Krishna, Schieborr, Ulrich, Anderka, Oliver, Duchardt-Ferner, Elke, Elshorst, Bettina, Gande, Santosh Lakshmi, Janzon, Julia, Kudlinzki, Denis, Sreeramulu, Sridhar, Dreyer, Matthias K., Wendt, K. Ulrich, Herbert, Corentin, Duchaussoy, Philippe, Bianciotto, Marc, Driguez, Pierre-Alexandre, Lassalle, Gilbert, Savi, Pierre, Mohammadi, Moosa, Bono, Françoise, Schwalbe, Harald
Published in The Journal of biological chemistry (20.08.2010)
Published in The Journal of biological chemistry (20.08.2010)
Get full text
Journal Article
Thermodynamic Characterization of Allosteric Glycogen Phosphorylase Inhibitors
Anderka, Oliver, Loenze, Petra, Klabunde, Thomas, Dreyer, Matthias K, Defossa, Elisabeth, Wendt, K. Ulrich, Schmoll, Dieter
Published in Biochemistry (Easton) (22.04.2008)
Published in Biochemistry (Easton) (22.04.2008)
Get full text
Journal Article
Crystal Structure of Human Cyclin-Dependent Kinase 2 in Complex with the Adenine-Derived Inhibitor H717
Dreyer, Matthias K, Borcherding, David R, Dumont, Jennifer A, Peet, Norton P, Tsay, Joseph T, Wright, Paul S, Bitonti, Alan J, Shen, Jian, Kim, Sung-Hou
Published in Journal of medicinal chemistry (15.02.2001)
Published in Journal of medicinal chemistry (15.02.2001)
Get full text
Journal Article
Rational design of potent GSK3b inhibitors with selectivity for Cdk1 and Cdk2
Lesuisse, Dominique, Dutruc-Rosset, Gilles, Tiraboschi, Gilles, Dreyer, Matthias K, Maignan, Sebastien, Chevalier, Alain, Halley, Frank, Bertrand, Philippe, Burgevin, Marie-Claude, Quarteronet, Dominique, Rooney, Thomas
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Get full text
Journal Article
Crystal structure of the BMP-2-BRIA ectodomain complex
Kirsch, Thomas, Sebald, Walter, Dreyer, Matthias K
Published in Nature structural & molecular biology (01.06.2000)
Published in Nature structural & molecular biology (01.06.2000)
Get full text
Journal Article
Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2
Lesuisse, Dominique, Dutruc-Rosset, Gilles, Tiraboschi, Gilles, Dreyer, Matthias K, Maignan, Sébastien, Chevalier, Alain, Halley, Frank, Bertrand, Philippe, Burgevin, Marie-Claude, Quarteronet, Dominique, Rooney, Thomas
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Get full text
Journal Article