Recent advances in the determination of G protein-coupled receptor structures
Thal, David M, Vuckovic, Ziva, Draper-Joyce, Christopher J, Liang, Yi-Lynn, Glukhova, Alisa, Christopoulos, Arthur, Sexton, Patrick M
Published in Current opinion in structural biology (01.08.2018)
Published in Current opinion in structural biology (01.08.2018)
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A new mechanism of allostery in a G protein-coupled receptor dimer
Lane, J Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J, Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J, Capuano, Ben, Sexton, Patrick M, Javitch, Jonathan A, Christopoulos, Arthur
Published in Nature chemical biology (01.09.2014)
Published in Nature chemical biology (01.09.2014)
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Journal Article
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex
Draper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa, Christopoulos, Arthur
Published in Nature (London) (20.06.2018)
Published in Nature (London) (20.06.2018)
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Journal Article
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
Draper-Joyce, Christopher J., Bhola, Rebecca, Wang, Jinan, Bhattarai, Apurba, Nguyen, Anh T. N., Cowie-Kent, India, O’Sullivan, Kelly, Chia, Ling Yeong, Venugopal, Hariprasad, Valant, Celine, Thal, David M., Wootten, Denise, Panel, Nicolas, Carlsson, Jens, Christie, Macdonald J., White, Paul J., Scammells, Peter, May, Lauren T., Sexton, Patrick M., Danev, Radostin, Miao, Yinglong, Glukhova, Alisa, Imlach, Wendy L., Christopoulos, Arthur
Published in Nature (London) (23.09.2021)
Published in Nature (London) (23.09.2021)
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Journal Article
Strength in numbers-an arrestin interaction code
Draper-Joyce, Christopher J, Christopoulos, Arthur
Published in Nature structural & molecular biology (01.06.2018)
Published in Nature structural & molecular biology (01.06.2018)
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Journal Article
Rules of Engagement: GPCRs and G Proteins
Glukhova, Alisa, Draper-Joyce, Christopher J, Sunahara, Roger K, Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M
Published in ACS pharmacology & translational science (09.11.2018)
Published in ACS pharmacology & translational science (09.11.2018)
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Journal Article
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor
Draper-Joyce, Christopher J., Michino, Mayako, Verma, Ravi Kumar, Klein Herenbrink, Carmen, Shonberg, Jeremy, Kopinathan, Anitha, Scammells, Peter J., Capuano, Ben, Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Published in Biochemical pharmacology (01.02.2018)
Published in Biochemical pharmacology (01.02.2018)
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Journal Article
Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D2 Receptor Through Fragmentation of a Bitopic Ligand
Mistry, Shailesh N., Shonberg, Jeremy, Draper-Joyce, Christopher J., Klein Herenbrink, Carmen, Michino, Mayako, Shi, Lei, Christopoulos, Arthur, Capuano, Ben, Scammells, Peter J., Lane, J. Robert
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
Positive allosteric modulation of a GPCR ternary complex
Burger, Wessel A. C., Draper-Joyce, Christopher J., Valant, Celine, Christopoulos, Arthur, Thal, David M.
Published in Science advances (13.09.2024)
Published in Science advances (13.09.2024)
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Journal Article
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole
Klein Herenbrink, Carmen, Verma, Ravi, Lim, Herman D, Kopinathan, Anitha, Keen, Alastair, Shonberg, Jeremy, Draper-Joyce, Christopher J, Scammells, Peter J, Christopoulos, Arthur, Javitch, Jonathan A, Capuano, Ben, Shi, Lei, Lane, J. Robert
Published in ACS chemical biology (16.08.2019)
Published in ACS chemical biology (16.08.2019)
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Journal Article
The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions
Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Published in Scientific reports (19.01.2018)
Published in Scientific reports (19.01.2018)
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Journal Article
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D 2 receptor
Draper-Joyce, Christopher J, Michino, Mayako, Verma, Ravi Kumar, Klein Herenbrink, Carmen, Shonberg, Jeremy, Kopinathan, Anitha, Scammells, Peter J, Capuano, Ben, Thal, David M, Javitch, Jonathan A, Christopoulos, Arthur, Shi, Lei, Lane, J Robert
Published in Biochemical pharmacology (01.02.2018)
Published in Biochemical pharmacology (01.02.2018)
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Journal Article
Positive allosteric mechanisms of adenosine A.sub.1 receptor-mediated analgesia
Draper-Joyce, Christopher J, Bhola, Rebecca, Wang, Jinan, Bhattarai, Apurba, Nguyen, Anh T. N, Cowie-Kent, India, O'Sullivan, Kelly, Chia, Ling Yeong, Venugopal, Hariprasad, Valant, Celine, Thal, David M, Wooten, Denise, Panel, Nicolas, Carlsson, Jens, Christie, Macdonald J, White, Paul J, Scammells, Peter
Published in Nature (London) (23.09.2021)
Published in Nature (London) (23.09.2021)
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Journal Article
Positive allosteric mechanisms of adenosine A(1) receptor-mediated analgesia
Draper-Joyce, Christopher J., Bhola, Rebecca, Wang, Jinan, Bhattarai, Apurba, Nguyen, Anh T. N., Cowie-Kent, India, O'Sullivan, Kelly, Chia, Ling Yeong, Venugopal, Hariprasad, Valant, Celine, Thal, David M., Wootten, Denise, Panel, Nicolas, Carlsson, Jens, Christie, Macdonald J., White, Paul J., Scammells, Peter, May, Lauren T., Sexton, Patrick M., Danev, Radostin, Miao, Yinglong, Glukhova, Alisa, Imlach, Wendy L., Christopoulos, Arthur
Published in Nature (London) (2021)
Published in Nature (London) (2021)
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Journal Article
Structure of the adenosine-bound human adenosine A^sub 1^ receptor–G^sub i^ complex
Draper-Joyce, Christopher J, Khoshouei, Maryam, Thal, David M, Liang, Yi-Lynn, Nguyen, Anh T N, Furness, Sebastian G B, Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M, Danev, Radostin, Baumeister, Wolfgang, May, Lauren T, Wootten, Denise, Sexton, Patrick M, Glukhova, Alisa, Christopoulos, Arthur
Published in Nature (London) (28.06.2018)
Published in Nature (London) (28.06.2018)
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Journal Article
Discovery of a Novel Class of Negative Allosteric Modulator of the Dopamine D 2 Receptor Through Fragmentation of a Bitopic Ligand
Mistry, Shailesh N., Shonberg, Jeremy, Draper-Joyce, Christopher J., Klein Herenbrink, Carmen, Michino, Mayako, Shi, Lei, Christopoulos, Arthur, Capuano, Ben, Scammells, Peter J., Lane, J. Robert
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia
Draper-Joyce, Christopher J, Bhola, Rebecca, Wang, Jinan, Bhattarai, Apurba, Nguyen, Anh T N, Cowie-Kent, India, O'Sullivan, Kelly, Chia, Ling Yeong, Venugopal, Hariprasad, Valant, Celine, Thal, David M, Wootten, Denise, Panel, Nicolas, Carlsson, Jens, Christie, Macdonald J, White, Paul J, Scammells, Peter, May, Lauren T, Sexton, Patrick M, Danev, Radostin, Miao, Yinglong, Glukhova, Alisa, Imlach, Wendy L, Christopoulos, Arthur
Published in Nature (London) (01.09.2021)
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Published in Nature (London) (01.09.2021)
Journal Article
The action of a negative allosteric modulator at the dopamine D 2 receptor is dependent upon sodium ions
Draper-Joyce, Christopher J, Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J, Capuano, Ben, Abramyan, Ara M, Thal, David M, Javitch, Jonathan A, Christopoulos, Arthur, Shi, Lei, Lane, J Robert
Published in Scientific reports (19.01.2018)
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Published in Scientific reports (19.01.2018)
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