High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions
Lourenço, André Luiz, Chuo, Shih-Wei, Bohn, Markus F, Hann, Byron, Khan, Shireen, Yevalekar, Neha, Patel, Nitin, Yang, Teddy, Xu, Lina, Lv, Dandan, Drakas, Robert, Lively, Sarah, Craik, Charles S
Published in mAbs (2023)
Published in mAbs (2023)
Get full text
Journal Article
Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates
Dudkin, Vadim Y., Rickert, Keith, Kreatsoulas, Constantine, Wang, Cheng, Arrington, Kenneth L., Fraley, Mark E., Hartman, George D., Yan, Yowei, Ikuta, Mari, Stirdivant, Steven M., Drakas, Robert A., Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A., Lobell, Robert B., Sepp-Lorenzino, Laura
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Get full text
Journal Article
Pyridyl aminothiazoles as potent Chk1 inhibitors: Optimization of cellular activity
Dudkin, Vadim Y., Wang, Cheng, Arrington, Kenneth L., Fraley, Mark E., Hartman, George D., Stirdivant, Steven M., Drakas, Robert A., Rickert, Keith, Walsh, Eileen S., Hamilton, Kelly, Buser, Carolyn A., Hardwick, James, Tao, Weikang, Beck, Stephen C., Mao, Xianzhi, Lobell, Robert B., Sepp-Lorenzino, Laura
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Get full text
Journal Article
Nuclear Translocation of Insulin Receptor Substrate-1 by the Simian Virus 40 T Antigen and the Activated Type 1 Insulin-like Growth Factor Receptor
Prisco, Marco, Santini, Francesca, Baffa, Raffaele, Liu, Mingli, Drakas, Robert, Wu, An, Baserga, Renato
Published in The Journal of biological chemistry (30.08.2002)
Published in The Journal of biological chemistry (30.08.2002)
Get full text
Journal Article
Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy against Kidney Fibrosis
Lee, Kyung, Drakas, Robert, He, John C
Published in Journal of the American Society of Nephrology (01.06.2024)
Published in Journal of the American Society of Nephrology (01.06.2024)
Get full text
Journal Article
Small Molecule Allosteric Inhibitor of HIPK2 as a Novel Therapy against Kidney Fibrosis
Lee, Kyung, Drakas, Robert, He, John C
Published in Journal of the American Society of Nephrology (01.06.2024)
Published in Journal of the American Society of Nephrology (01.06.2024)
Get full text
Journal Article
Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases
Bell, Ian M, Stirdivant, Steven M, Ahern, Janet, Culberson, J. Christopher, Darke, Paul L, Dinsmore, Christopher J, Drakas, Robert A, Gallicchio, Steven N, Graham, Samuel L, Heimbrook, David C, Hall, Dawn L, Hua, Jin, Kett, Nathan R, Kim, Annette S, Kornienko, Maria, Kuo, Lawrence C, Munshi, Sanjeev K, Quigley, Amy G, Reid, John C, Trotter, B. Wesley, Waxman, Lloyd H, Williams, Theresa M, Zartman, C. Blair
Published in Biochemistry (Easton) (12.07.2005)
Published in Biochemistry (Easton) (12.07.2005)
Get full text
Journal Article
Mechanistic Evaluation and In Vivo Validation of a Novel HIPK2 Inhibitor as Anti-Fibrosis Therapy for Kidney Disease: FR-PO946
Lee, Kyung, Feng, Ye, Chen, Yibang, Beresis, Richard T., Drakas, Robert, He, John C.
Published in Journal of the American Society of Nephrology (01.11.2022)
Published in Journal of the American Society of Nephrology (01.11.2022)
Get full text
Journal Article
A Novel Allosteric HIPK2 Inhibitor Attenuates Renal Fibrosis with Superior Pharmacokinetic, Selectivity, and Safety Profiles: PO2474
Lee, Kyung, Feng, Ye, Chen, Ya, Beresis, Richard T., Drakas, Robert, He, John C.
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
Get full text
Journal Article
Regulation of Id1 Protein Expression in Mouse Embryo Fibroblasts by the Type 1 Insulin-like Growth Factor Receptor
Belletti, Barbara, Drakas, Robert, Morrione, Andrea, Tu, Xiao, Prisco, Marco, Yuan, Tina, Casaburi, Ivan, Baserga, Renato
Published in Experimental cell research (01.07.2002)
Published in Experimental cell research (01.07.2002)
Get full text
Journal Article
Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 (34) for Autoimmune Disorders
He, Yuanjun, Zhu, Di, Greenman, Kevin, Ruiz, Claudia, Shang, Jinsai, Lu, Qun, Kojetin, Douglas J., Drakas, Robert, Cameron, Michael D., Lizarzaburu, Mike, Solt, Laura A., Kamenecka, Theodore M.
Published in Journal of medicinal chemistry (09.11.2023)
Published in Journal of medicinal chemistry (09.11.2023)
Get full text
Journal Article
Abstract 5228: Small molecule activation of the LKB1 tumor suppressor
Mitchell, Dominique C., Liu, Jin, Wang, Zheng, He, Changliang, Ding, Luo, Adler, Marc, Wang, LeeAnn L., Keith, Aidan, Hwang, Y. Christina, Tsui, Tsz Kin M., Ramamoorthi, Roopa, Lively, Sarah, Drakas, Robert A., Ramani, Vijay, Verba, Kliment A., Qing, Tingting, Beresis, Richard T., Gordan, John D.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin
Chen, Jia, Wu, An, Sun, Hongzhi, Drakas, Robert, Garofalo, Cecilia, Cascio, Sandra, Surmacz, Eva, Baserga, Renato
Published in The Journal of biological chemistry (19.08.2005)
Published in The Journal of biological chemistry (19.08.2005)
Get full text
Journal Article
Pyridyi aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates
DUDKIN, Vadim Y, RICKERT, Keith, DRAKAS, Robert A, WALSH, Eileen S, HAMILTON, Kelly, BUSER, Carolyn A, LOBELL, Robert B, SEPP-LORENZINO, Laura, KREATSOULAS, Constantine, CHENG WANG, ARRINGTON, Kenneth L, FRALEY, Mark E, HARTMAN, George D, YOWEI YAN, IKUTA, Mari, STIRDIVANT, Steven M
Published in Bioorganic & medicinal chemistry letters (2012)
Get full text
Published in Bioorganic & medicinal chemistry letters (2012)
Journal Article
Functional Significance of Type 1 Insulin-like Growth Factor-mediated Nuclear Translocation of the Insulin Receptor Substrate-1 and β-Catenin
Jia Chen, An Wu, Hongzhi Sun, Robert Drakas, Cecilia Garofalo, Sandra Cascio, Eva Surmacz, Renato Baserga
Published in The Journal of biological chemistry (19.08.2005)
Published in The Journal of biological chemistry (19.08.2005)
Get full text
Journal Article