Structure-Assisted Design of Mechanism-Based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity against Multiple Rhinovirus Serotypes
Matthews, D A, Dragovich, P S, Webber, S E, Fuhrman, S A, Patick, A K, Zalman, L S, Hendrickson, T F, Love, R A, Prins, T J, Marakovits, J T, Zhou, R, Tikhe, J, Ford, C E, Meador, J W, Ferre, R A, Brown, E L, Binford, S L, Brothers, M A, DeLisle, D M, Worland, S T
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (28.09.1999)
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In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease
PATICK, A. K, BINFORD, S. L, FUHRMAN, S. A, MEADOR, J. W, ZALMAN, L. S, MATTHEWS, D. A, WORLAND, S. T, BROTHERS, M. A, JACKSON, R. L, FORD, C. E, DIEM, M. D, MALDONADO, F, DRAGOVICH, P. S, ZHOU, R, PRINS, T. J
Published in Antimicrobial Agents and Chemotherapy (01.10.1999)
Published in Antimicrobial Agents and Chemotherapy (01.10.1999)
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Journal Article
Inhibition of Human Rhinovirus-Induced Cytokine Production by AG7088, a Human Rhinovirus 3C Protease Inhibitor
ZALMAN, L. S, BROTHERS, M. A, DRAGOVICH, P. S, ZHOU, R, PRINS, T. J, WORLAND, S. T, PATICK, A. K
Published in Antimicrobial Agents and Chemotherapy (01.05.2000)
Published in Antimicrobial Agents and Chemotherapy (01.05.2000)
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Journal Article
Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines
Misner, D. L., Kauss, M. A., Singh, J., Uppal, H., Bruening-Wright, A., Liederer, B. M., Lin, T., McCray, B., La, N., Nguyen, T., Sampath, D., Dragovich, P. S., O’Brien, T., Zabka, T. S.
Published in Cardiovascular toxicology (01.07.2017)
Published in Cardiovascular toxicology (01.07.2017)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 3. Structure−Activity Studies of Ketomethylene-Containing Peptidomimetics
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme
Love, Robert A, Parge, Hans E, Yu, Xiu, Hickey, Michael J, Diehl, Wade, Gao, Jingjin, Wriggers, Hilary, Ekker, Anne, Wang, Liann, Thomson, James A, Dragovich, Peter S, Fuhrman, Shella A
Published in Journal of Virology (01.07.2003)
Published in Journal of Virology (01.07.2003)
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Journal Article
The Crystal Structure of the RNA-Dependent RNA Polymerase from Human Rhinovirus: A Dual Function Target for Common Cold Antiviral Therapy
Love, Robert A, Maegley, Karen A, Yu, Xiu, Ferre, Rose Ann, Lingardo, Laura K, Diehl, Wade, Parge, Hans E, Dragovich, Peter S, Fuhrman, Shella A
Published in Structure (London) (01.08.2004)
Published in Structure (London) (01.08.2004)
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Journal Article
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids
Dragovich, Peter S, Webber, Stephen E, Prins, Thomas J, Zhou, Ru, Marakovits, Joseph T, Tikhe, Jayashree G, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Ford, Clifford E, Brown, Edward L, Binford, Susan L, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
Published in Bioorganic & medicinal chemistry letters (02.08.1999)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 6. Structure−Activity Studies of Orally Bioavailable, 2-Pyridone-Containing Peptidomimetics
Dragovich, Peter S, Prins, Thomas J, Zhou, Ru, Brown, Edward L, Maldonado, Fausto C, Fuhrman, Shella A, Zalman, Leora S, Tuntland, Tove, Lee, Caroline A, Patick, Amy K, Matthews, David A, Hendrickson, Thomas F, Kosa, Maha B, Liu, Bo, Batugo, Minerva R, Gleeson, Jean-Paul R, Sakata, Sylvie K, Chen, Lijian, Guzman, Mark C, Meador, James W, Ferre, Rose Ann, Worland, Stephen T
Published in Journal of medicinal chemistry (11.04.2002)
Published in Journal of medicinal chemistry (11.04.2002)
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Journal Article
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 1. Michael Acceptor Structure−Activity Studies
Dragovich, Peter S, Webber, Stephen E, Babine, Robert E, Fuhrman, Shella A, Patick, Amy K, Matthews, David A, Lee, Caroline A, Reich, Siegfried H, Prins, Thomas J, Marakovits, Joseph T, Littlefield, Ethel S, Zhou, Ru, Tikhe, Jayashree, Ford, Clifford E, Wallace, Michael B, Meador, James W, Ferre, Rose Ann, Brown, Edward L, Binford, Susan L, Harr, James E. V, DeLisle, Dorothy M, Worland, Stephen T
Published in Journal of medicinal chemistry (16.07.1998)
Published in Journal of medicinal chemistry (16.07.1998)
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Journal Article
Studies on the thermal generation and reactivity of a class of (.sigma.,.pi.)-1,4-biradicals
Myers, Andrew G, Dragovich, Peter S, Kuo, Elaine Y
Published in Journal of the American Chemical Society (01.11.1992)
Published in Journal of the American Chemical Society (01.11.1992)
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Journal Article
Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates
Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S, Pillow, Thomas H, Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D, Erickson, Hans K, Hop, Cornelis E C A, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.09.2016)
Published in Drug metabolism and disposition (01.09.2016)
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Journal Article
Solid-phase synthesis of irreversible human rhinovirus 3C protease inhibitors. Part 1: Optimization of tripeptides incorporating N-terminal amides
Dragovich, Peter S., Zhou, Ru, Skalitzky, Donald J., Fuhrman, Shella A., Patick, Amy K., Ford, Clifford E., Meador, James W., Worland, Stephen T.
Published in Bioorganic & medicinal chemistry (01.04.1999)
Published in Bioorganic & medicinal chemistry (01.04.1999)
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Journal Article
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors
DRAGOVICH, P. S, RU ZHOU, MEADOR, J. W, PATICK, A. K, FORD, C. E, BROTHERS, M. A, BINFORD, S. L, MATTHEWS, D. A, FERRE, R. A, WORLAND, S. T, WEBBER, S. E, PRINS, T. J, KWOK, A. K, OKANO, K, FUHRMAN, S. A, ZALMAN, L. S, MALDONADO, F. C, BROWN, E. L
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
Published in Bioorganic & medicinal chemistry letters (03.01.2000)
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Journal Article
Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors
Dragovich, Peter S, Barker, John E, French, Judy, Imbacuan, Michael, Kalish, Vincent J, Kissinger, Charles R, Knighton, Daniel R, Lewis, Cristina T, Moomaw, Ellen W, Parge, Hans E, Pelletier, Laura A. K, Prins, Thomas J, Showalter, Richard E, Tatlock, John H, Tucker, Kathleen D, Villafranca, J. Ernest
Published in Journal of medicinal chemistry (26.04.1996)
Published in Journal of medicinal chemistry (26.04.1996)
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Spectroscopic and crystallographic characterization of (σ2-terpyridyl)Re(CO)3Cl. 2D-NMR evidence for a linkage isomerization reaction
CIVITELLO, E. R, DRAGOVICH, P. S, KARPISHIN, T. B, NOVICK, S. G, BIERACH, G, O'CONNELL, J. F, WESTMORELAND, T. D
Published in Inorganic chemistry (20.01.1993)
Published in Inorganic chemistry (20.01.1993)
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Journal Article
An optical thin film assay incorporating rhinovirus protease inhibitors as detector reagents
Ettinger, Anna, Ostroff, Rachel, Rhihanek, Marynette, Dragovich, Peter S, Zalman, Leora S, Patick, Amy K, Prins, Thomas J, Fuhrman, Shella A, Brown, Edward L, Worland, Stephen T, Polisky, Barry
Published in Antiviral research (01.03.2004)
Published in Antiviral research (01.03.2004)
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Journal Article
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors
Webber, Stephen E., Marakovits, Joseph T., Dragovich, Peter S., Prins, Thomas J., Zhou, Ru, Fuhrman, Shella A., Patick, Amy K., Matthews, David A., Lee, Caroline A., Srinivasan, Babu, Moran, Terry, Ford, Clifford E., Brothers, Mary A., Harr, James E.V., Meador, James W., Ferre, Rose Ann, Worland, Stephen T.
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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