Highly selective inhibitors of protein kinases CLK and HIPK with the furo[3,2-b]pyridine core
Němec, Václav, Maier, Lukáš, Berger, Benedict-Tilman, Chaikuad, Apirat, Drápela, Stanislav, Souček, Karel, Knapp, Stefan, Paruch, Kamil
Published in European journal of medicinal chemistry (05.04.2021)
Published in European journal of medicinal chemistry (05.04.2021)
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Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Němec, Václav, Hylsová, Michaela, Maier, Lukáš, Flegel, Jana, Sievers, Sonja, Ziegler, Slava, Schröder, Martin, Berger, Benedict‐Tilman, Chaikuad, Apirat, Valčíková, Barbora, Uldrijan, Stjepan, Drápela, Stanislav, Souček, Karel, Waldmann, Herbert, Knapp, Stefan, Paruch, Kamil
Published in Angewandte Chemie International Edition (21.01.2019)
Published in Angewandte Chemie International Edition (21.01.2019)
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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe
Drápela, Stanislav, Khirsariya, Prashant, Weerden, Wytske M., Fedr, Radek, Suchánková, Tereza, Búzová, Diana, Červený, Jan, Hampl, Aleš, Puhr, Martin, Watson, William R., Culig, Zoran, Krejčí, Lumír, Paruch, Kamil, Souček, Karel
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Transcription factor c-Myb: novel prognostic factor in osteosarcoma
Říhová, Kamila, Dúcka, Monika, Zambo, Iva Staniczková, Vymětalová, Ladislava, Šrámek, Martin, Trčka, Filip, Verner, Jan, Drápela, Stanislav, Fedr, Radek, Suchánková, Tereza, Pavlatovská, Barbora, Ondroušková, Eva, Kubelková, Irena, Zapletalová, Danica, Tuček, Štěpán, Múdry, Peter, Krákorová, Dagmar Adámková, Knopfová, Lucia, Šmarda, Jan, Souček, Karel, Borsig, Lubor, Beneš, Petr
Published in Clinical & experimental metastasis (01.04.2022)
Published in Clinical & experimental metastasis (01.04.2022)
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Diastereoselective Flexible Synthesis of Carbocyclic C‑Nucleosides
Maier, Lukáš, Khirsariya, Prashant, Hylse, Ondřej, Adla, Santosh Kumar, Černová, Lenka, Poljak, Michal, Krajčovičová, Soňa, Weis, Erik, Drápela, Stanislav, Souček, Karel, Paruch, Kamil
Published in Journal of organic chemistry (07.04.2017)
Published in Journal of organic chemistry (07.04.2017)
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Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis
Muresan, Ximena M., Slabáková, Eva, Procházková, Jiřina, Drápela, Stanislav, Fedr, Radek, Pícková, Markéta, Vacek, Ondřej, Víchová, Ráchel, Suchánková, Tereza, Bouchal, Jan, Kürfürstová, Daniela, Král, Milan, Hulínová, Tereza, Sýkora, Radek P., Študent, Vladimír, Hejret, Václav, van Weerden, Wytske M., Puhr, Martin, Pustka, Václav, Potěšil, David, Zdráhal, Zbyněk, Culig, Zoran, Souček, Karel
Published in The American journal of pathology (01.09.2022)
Published in The American journal of pathology (01.09.2022)
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Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells
Drápela, Stanislav, Kvokačková, Barbora, Slabáková, Eva, Kotrbová, Anna, Gömöryová, Kristína, Fedr, Radek, Kurfürstová, Daniela, Eliáš, Martin, Študent, Jr, Vladimír, Lenčéšová, Frederika, Ranjani, Ganji Sri, Pospíchalová, Vendula, Bryja, Vítězslav, van Weerden, Wytske M, Puhr, Martin, Culig, Zoran, Bouchal, Jan, Souček, Karel
Published in Cellular oncology (Dordrecht) (20.08.2024)
Published in Cellular oncology (Dordrecht) (20.08.2024)
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Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
Samadder, Pounami, Suchánková, Tereza, Hylse, Ondřej, Khirsariya, Prashant, Nikulenkov, Fedor, Drápela, Stanislav, Straková, Nicol, Vaňhara, Petr, Vašíčková, Kateřina, Kolářová, Hana, Binó, Lucia, Bittová, Miroslava, Ovesná, Petra, Kollár, Peter, Fedr, Radek, Ešner, Milan, Jaroš, Josef, Hampl, Aleš, Krejčí, Lumír, Paruch, Kamil, Souček, Karel
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Published in Molecular cancer therapeutics (01.09.2017)
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Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells
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Published in Haematologica (Roma) (01.12.2019)
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NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis
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Published in Redox biology (01.05.2023)
Published in Redox biology (01.05.2023)
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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel#8208;resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe
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Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Advantages and limitations of 3D organoids and ex vivo tumor tissue culture in personalized medicine for prostate cancer
Mickova, A, Morong, M, Levková, M, Kurfúrstová, D, Kharaishvili, G, Überall, I, Student, Jr, V, Student, V, Drapela, S-, Soucek, K-, Bouchal, J
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Published in Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti (2022)
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Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Němec, Václav, Hylsová, Michaela, Maier, Lukáš, Flegel, Jana, Sievers, Sonja, Ziegler, Slava, Schröder, Martin, Berger, Benedict‐Tilman, Chaikuad, Apirat, Valčíková, Barbora, Uldrijan, Stjepan, Drápela, Stanislav, Souček, Karel, Waldmann, Herbert, Knapp, Stefan, Paruch, Kamil
Published in Angewandte Chemie (21.01.2019)
Published in Angewandte Chemie (21.01.2019)
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Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8 + T cells to suppress anti-tumor immunity
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Published in Oncogene (29.10.2024)
Published in Oncogene (29.10.2024)
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