The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans
Dowty, Martin E, Lin, Jinyan, Ryder, Tim F, Wang, Weiwei, Walker, Gregory S, Vaz, Alfin, Chan, Gary L, Krishnaswami, Sriram, Prakash, Chandra
Published in Drug metabolism and disposition (01.04.2014)
Published in Drug metabolism and disposition (01.04.2014)
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Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
Meyer, Debra M, Jesson, Michael I, Li, Xiong, Elrick, Mollisa M, Funckes-Shippy, Christie L, Warner, James D, Gross, Cindy J, Dowty, Martin E, Ramaiah, Shashi K, Hirsch, Jeffrey L, Saabye, Matthew J, Barks, Jennifer L, Kishore, Nandini, Morris, Dale L
Published in Journal of inflammation (London, England) (11.08.2010)
Published in Journal of inflammation (London, England) (11.08.2010)
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Journal Article
The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis
Hodge, Jennifer A, Kawabata, Thomas T, Krishnaswami, Sriram, Clark, James D, Telliez, Jean-Baptiste, Dowty, Martin E, Menon, Sujatha, Lamba, Manisha, Zwillich, Samuel
Published in Clinical and experimental rheumatology (01.03.2016)
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Published in Clinical and experimental rheumatology (01.03.2016)
Journal Article
Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug‐Drug Interactions or in Special Populations: An Example Using Tofacitinib
Tse, Susanna, Dowty, Martin E., Menon, Sujatha, Gupta, Pankaj, Krishnaswami, Sriram
Published in Journal of clinical pharmacology (01.12.2020)
Published in Journal of clinical pharmacology (01.12.2020)
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Journal Article
Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model
Saadeddin, Anas, Purohit, Vivek, Huh, Yeamin, Wong, Mei, Maulny, Aurelia, Dowty, Martin E., Sagawa, Kazuko
Published in The AAPS journal (24.01.2024)
Published in The AAPS journal (24.01.2024)
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Journal Article
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
Ghoreschi, Kamran, Jesson, Michael I, Li, Xiong, Lee, Jamie L, Ghosh, Sarbani, Alsup, Jason W, Warner, James D, Tanaka, Masao, Steward-Tharp, Scott M, Gadina, Massimo, Thomas, Craig J, Minnerly, John C, Storer, Chad E, LaBranche, Timothy P, Radi, Zaher A, Dowty, Martin E, Head, Richard D, Meyer, Debra M, Kishore, Nandini, O'Shea, John J
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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Journal Article
Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
Guttman-Yassky, Emma, Pavel, Ana B., Diaz, Aisleen, Zhang, Ning, Del Duca, Ester, Estrada, Yeriel, King, Brett, Banerjee, Anindita, Banfield, Christopher, Cox, Lori Ann, Dowty, Martin E., Page, Karen, Vincent, Michael S., Zhang, Weidong, Zhu, Linda, Peeva, Elena
Published in Journal of allergy and clinical immunology (01.04.2022)
Published in Journal of allergy and clinical immunology (01.04.2022)
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Journal Article
Correction: Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model
Saadeddin, Anas, Purohit, Vivek, Huh, Yeamin, Wong, Mei, Maulny, Aurelia, Dowty, Martin E., Sagawa, Kazuko
Published in The AAPS journal (21.02.2024)
Published in The AAPS journal (21.02.2024)
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Journal Article
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a TYK2/JAK1 Inhibitor (PF-06700841) in Healthy Subjects and Patients With Plaque Psoriasis
Banfield, Christopher, Scaramozza, Matthew, Zhang, Weidong, Kieras, Elizabeth, Page, Karen M, Fensome, Andrew, Vincent, Michael, Dowty, Martin E, Goteti, Kosalaram, Winkle, Peter J, Peeva, Elena
Published in Journal of clinical pharmacology (01.04.2018)
Published in Journal of clinical pharmacology (01.04.2018)
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Journal Article
Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis
Dowty, Martin E, Jesson, Michael I, Ghosh, Sarbani, Lee, Jamie, Meyer, Debra M, Krishnaswami, Sriram, Kishore, Nandini
Published in The Journal of pharmacology and experimental therapeutics (01.01.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2014)
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Journal Article
A phase 1 study to investigate the absorption, distribution, metabolism and excretion of brepocitinib in healthy males using a 14 C-microdose approach
Qiu, Ruolun, Sharma, Raman, Wei, Hua, Kirkovsky, Leonid, Zhou, Yifan, Martin, David D A, Banfield, Christopher, Dowty, Martin E
Published in British journal of clinical pharmacology (01.10.2023)
Published in British journal of clinical pharmacology (01.10.2023)
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Journal Article
Identification of N‑{cis-3-[Methyl(7H‑pyrrolo[2,3‑d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases
Vazquez, Michael L, Kaila, Neelu, Strohbach, Joseph W, Trzupek, John D, Brown, Matthew F, Flanagan, Mark E, Mitton-Fry, Mark J, Johnson, Timothy A, TenBrink, Ruth E, Arnold, Eric P, Basak, Arindrajit, Heasley, Steven E, Kwon, Soojin, Langille, Jonathan, Parikh, Mihir D, Griffin, Sarah H, Casavant, Jeffrey M, Duclos, Brian A, Fenwick, Ashley E, Harris, Thomas M, Han, Seungil, Caspers, Nicole, Dowty, Martin E, Yang, Xin, Banker, Mary Ellen, Hegen, Martin, Symanowicz, Peter T, Li, Li, Wang, Lu, Lin, Tsung H, Jussif, Jason, Clark, James D, Telliez, Jean-Baptiste, Robinson, Ralph P, Unwalla, Ray
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Journal Article
Integrating Clinical Variability into PBPK Models for Virtual Bioequivalence of Single and Multiple Doses of Tofacitinib Modified-Release Dosage Form
Purohit, Vivek, Sagawa, Kazuko, Hsu, Hao-Jui, Kushner, Joseph, Dowty, Martin E, Tse, Susanna, Lin, Jian, Blanchard, Andrew, Mukherjee, Arnab, Le, Vu, Chang, Cheng
Published in Clinical pharmacology and therapeutics (26.05.2024)
Published in Clinical pharmacology and therapeutics (26.05.2024)
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Journal Article
Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites
Wang, Ellen Q., Le, Vu, Winton, Jennifer A., Tripathy, Sakambari, Raje, Sangeeta, Wang, Lisy, Dowty, Martin E., Malhotra, Bimal K.
Published in Journal of clinical pharmacology (01.04.2022)
Published in Journal of clinical pharmacology (01.04.2022)
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Journal Article
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Gerstenberger, Brian S, Ambler, Catherine, Arnold, Eric P, Banker, Mary-Ellen, Brown, Matthew F, Clark, James D, Dermenci, Alpay, Dowty, Martin E, Fensome, Andrew, Fish, Susan, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Knafels, John D, Lin, David W, Lin, Tsung H, Owen, Dafydd R, Saiah, Eddine, Sharma, Raman, Vajdos, Felix F, Xing, Li, Yang, Xiaojing, Yang, Xin, Wright, Stephen W
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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Journal Article
The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
Bauman, Jonathan N, Doran, Angela C, King-Ahmad, Amanda, Sharma, Raman, Walker, Gregory S, Lin, Jian, Lin, Tsung H, Telliez, Jean-Baptiste, Tripathy, Sakambari, Goosen, Theunis C, Banfield, Christopher, Malhotra, Bimal K, Dowty, Martin E
Published in Drug metabolism and disposition (01.08.2022)
Published in Drug metabolism and disposition (01.08.2022)
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Journal Article
Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition
Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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Journal Article
Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans
Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors
Casimiro-Garcia, Agustin, Trujillo, John I, Vajdos, Felix, Juba, Brian, Banker, Mary Ellen, Aulabaugh, Ann, Balbo, Paul, Bauman, Jonathan, Chrencik, Jill, Coe, Jotham W, Czerwinski, Robert, Dowty, Martin, Knafels, John D, Kwon, Soojin, Leung, Louis, Liang, Sidney, Robinson, Ralph P, Telliez, Jean-Baptiste, Unwalla, Ray, Yang, Xin, Thorarensen, Atli
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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