Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
Niraula, Saroj, Dowling, Ryan J. O., Ennis, Marguerite, Chang, Martin C., Done, Susan J., Hood, Nicky, Escallon, Jaime, Leong, Wey Liang, McCready, David R., Reedijk, Michael, Stambolic, Vuk, Goodwin, Pamela J.
Published in Breast cancer research and treatment (01.10.2012)
Published in Breast cancer research and treatment (01.10.2012)
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Journal Article
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
Dowling, Ryan J.O, Topisirovic, Ivan, Alain, Tommy, Bidinosti, Michael, Fonseca, Bruno D, Petroulakis, Emmanuel, Wang, Xiaoshan, Larsson, Ola, Selvaraj, Anand, Liu, Yi, Kozma, Sara C, Thomas, George, Sonenberg, Nahum
Published in Science (American Association for the Advancement of Science) (28.05.2010)
Published in Science (American Association for the Advancement of Science) (28.05.2010)
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Journal Article
Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy
Dowling, Ryan J.O., Lam, Sonya, Bassi, Christian, Mouaaz, Samar, Aman, Ahmed, Kiyota, Taira, Al-awar, Rima, Goodwin, Pamela J., Stambolic, Vuk
Published in Cell metabolism (12.04.2016)
Published in Cell metabolism (12.04.2016)
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Journal Article
Translational control of the innate immune response through IRF-7
Jaramillo, Maritza, Rong, Liwei, Martineau, Yvan, Costa-Mattioli, Mauro, Svitkin, Yuri V, Tai, Lee-Hwa, Sonenberg, Nahum, Bell, John C, Colina, Rodney, Breitbach, Caroline J, Makrigiannis, Andrew P, Dowling, Ryan J. O, Larsson, Ola
Published in Nature (20.03.2008)
Published in Nature (20.03.2008)
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Journal Article
Dissecting the role of mTOR: Lessons from mTOR inhibitors
Dowling, Ryan J.O., Topisirovic, Ivan, Fonseca, Bruno D., Sonenberg, Nahum
Published in Biochimica et biophysica acta (01.03.2010)
Published in Biochimica et biophysica acta (01.03.2010)
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Journal Article
Metformin in cancer: translational challenges
Dowling, Ryan J O, Niraula, Saroj, Stambolic, Vuk, Goodwin, Pamela J
Published in Journal of molecular endocrinology (01.06.2012)
Published in Journal of molecular endocrinology (01.06.2012)
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Journal Article
Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial
Hadad, Sirwan M., Coates, Philip, Jordan, Lee B., Dowling, Ryan J. O., Chang, Martin C., Done, Susan J., Purdie, Colin A., Goodwin, Pamela J., Stambolic, Vuk, Moulder-Thompson, Stacy, Thompson, Alastair M.
Published in Breast cancer research and treatment (01.02.2015)
Published in Breast cancer research and treatment (01.02.2015)
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Journal Article
Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study
Dowling, Ryan J O, Niraula, Saroj, Chang, Martin C, Done, Susan J, Ennis, Marguerite, McCready, David R, Leong, Wey L, Escallon, Jaime M, Reedijk, Michael, Goodwin, Pamela J, Stambolic, Vuk
Published in Breast cancer research : BCR (03.03.2015)
Published in Breast cancer research : BCR (03.03.2015)
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Journal Article
PTEN Nuclear Functions
Ho, Jason, Cruise, Edward S, Dowling, Ryan J O, Stambolic, Vuk
Published in Cold Spring Harbor perspectives in medicine (01.05.2020)
Published in Cold Spring Harbor perspectives in medicine (01.05.2020)
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Journal Article
A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy
Pimentel, Isabel, Lohmann, Ana Elisa, Ennis, Marguerite, Dowling, Ryan J.O., Cescon, David, Elser, C., Potvin, K.R., Haq, R., Hamm, C., Chang, Martin C., Stambolic, Vuk, Goodwin, Pamela J.
Published in Breast (Edinburgh) (01.12.2019)
Published in Breast (Edinburgh) (01.12.2019)
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Journal Article
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
Ligibel, Jennifer A, Dillon, Deborah, Giobbie-Hurder, Anita, McTiernan, Anne, Frank, Elizabeth, Cornwell, MacIntosh, Pun, Matthew, Campbell, Nancy, Dowling, Ryan J O, Chang, Martin C, Tolaney, Sara, Chagpar, Anees B, Yung, Rachel L, Freedman, Rachel A, Dominici, Laura S, Golshan, Mehra, Rhei, Esther, Taneja, Krishan, Huang, Ying, Brown, Myles, Winer, Eric P, Jeselsohn, Rinath, Irwin, Melinda L
Published in Clinical cancer research (01.09.2019)
Published in Clinical cancer research (01.09.2019)
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Journal Article
Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E
Herdy, Barbara, Jaramillo, Maritza, Svitkin, Yuri V, Rosenfeld, Amy B, Kobayashi, Mariko, Walsh, Derek, Alain, Tommy, Sean, Polen, Robichaud, Nathaniel, Topisirovic, Ivan, Furic, Luc, Dowling, Ryan J O, Sylvestre, Annie, Rong, Liwei, Colina, Rodney, Costa-Mattioli, Mauro, Fritz, Jörg H, Olivier, Martin, Brown, Earl, Mohr, Ian, Sonenberg, Nahum
Published in Nature immunology (01.06.2012)
Published in Nature immunology (01.06.2012)
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Journal Article
The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase
Zakikhani, Mahvash, Dowling, Ryan J O, Sonenberg, Nahum, Pollak, Michael N
Published in Cancer prevention research (Philadelphia, Pa.) (01.10.2008)
Published in Cancer prevention research (Philadelphia, Pa.) (01.10.2008)
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Journal Article
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
ZAKIKHANI, Mahvash, DOWLING, Ryan, FANTUS, I. George, SONENBERG, Nahum, POLLAK, Michael
Published in Cancer research (Chicago, Ill.) (01.11.2006)
Published in Cancer research (Chicago, Ill.) (01.11.2006)
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Journal Article
The Effect of Metformin vs Placebo on Sex Hormones in Canadian Cancer Trials Group MA.32
Pimentel, Isabel, Chen, Bingshu E, Lohmann, Ana Elisa, Ennis, Marguerite, Ligibel, Jennifer, Shepherd, Lois, Hershman, Dawn L, Whelan, Timothy, Stambolic, Vuk, Mayer, Ingrid, Hobday, Timothy, Lemieux, Julie, Thompson, Alastair, Rastogi, Priya, Gelmon, Karen, Rea, Daniel, Rabaglio, Manuela, Ellard, Susan, Mates, Mihaela, Bedard, Philippe, Pitre, Lacey, Vandenberg, Theodore, Dowling, Ryan J O, Parulekar, Wendy, Goodwin, Pamela J
Published in JNCI : Journal of the National Cancer Institute (01.02.2021)
Published in JNCI : Journal of the National Cancer Institute (01.02.2021)
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Journal Article
p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs
Petroulakis, Emmanuel, Parsyan, Armen, Dowling, Ryan J.O., LeBacquer, Olivier, Martineau, Yvan, Bidinosti, Michael, Larsson, Ola, Alain, Tommy, Rong, Liwei, Mamane, Yaël, Paquet, Marilene, Furic, Luc, Topisirovic, Ivan, Shahbazian, David, Livingstone, Mark, Costa-Mattioli, Mauro, Teodoro, Jose G., Sonenberg, Nahum
Published in Cancer cell (06.11.2009)
Published in Cancer cell (06.11.2009)
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Journal Article
Insulin receptor loss impairs mammary tumorigenesis in mice
Podmore, Lauren, Poloz, Yekaterina, Iorio, Catherine, Mouaaz, Samar, Nixon, Kevin, Smirnov, Petr, McDonnell, Brianna, Lam, Sonya, Zhang, Bowen, Tharmapalan, Pirashaanthy, Sarkar, Soumili, Vyas, Foram, Ennis, Marguerite, Dowling, Ryan, Stambolic, Vuk
Published in Cell reports (Cambridge) (28.11.2023)
Published in Cell reports (Cambridge) (28.11.2023)
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Journal Article