The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma
Lowery, Caitlin D, VanWye, Alle B, Dowless, Michele, Blosser, Wayne, Falcon, Beverly L, Stewart, Julie, Stephens, Jennifer, Beckmann, Richard P, Bence Lin, Aimee, Stancato, Louis F
Published in Clinical cancer research (01.08.2017)
Published in Clinical cancer research (01.08.2017)
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Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases
KONICEK, Bruce W, STEPHENS, Jennifer R, MCCANN, Denis J, PELLETIER, Jerry, FURIC, Luc, YINGLING, Jonathan M, STANCATO, Louis F, SONENBERG, Nahum, GRAFF, Jeremy R, MCNULTY, Ann M, ROBICHAUD, Nathaniel, PEERY, Robert B, DUMSTORF, Chad A, DOWLESS, Michele S, IVERSEN, Philip W, PARSONS, Stephen, ELLIS, Karen E
Published in Cancer research (Chicago, Ill.) (01.03.2011)
Published in Cancer research (Chicago, Ill.) (01.03.2011)
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Journal Article
Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling
Dowless, Michele, Lowery, Caitlin D, Shackleford, Terry, Renschler, Matthew, Stephens, Jennifer, Flack, Robert, Blosser, Wayne, Gupta, Simone, Stewart, Julie, Webster, Yue, Dempsey, Jack, VanWye, Alle B, Ebert, Philip, Iversen, Philip, Olsen, Jonathan B, Gong, Xueqian, Buchanan, Sean, Houghton, Peter, Stancato, Louis
Published in Clinical cancer research (01.12.2018)
Published in Clinical cancer research (01.12.2018)
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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
Graff, Jeremy R, Konicek, Bruce W, Vincent, Thomas M, Lynch, Rebecca L, Monteith, David, Weir, Spring N, Schwier, Phil, Capen, Andrew, Goode, Robin L, Dowless, Michele S, Chen, Yuefeng, Zhang, Hong, Sissons, Sean, Cox, Karen, McNulty, Ann M, Parsons, Stephen H, Wang, Tao, Sams, Lillian, Geeganage, Sandaruwan, Douglass, Larry E, Neubauer, Blake Lee, Dean, Nicholas M, Blanchard, Kerry, Shou, Jianyong, Stancato, Louis F, Carter, Julia H, Marcusson, Eric G
Published in The Journal of clinical investigation (01.09.2007)
Published in The Journal of clinical investigation (01.09.2007)
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Journal Article
Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α
Lowery, Caitlin D, Blosser, Wayne, Dowless, Michele, Knoche, Shelby, Stephens, Jennifer, Li, Huiling, Surguladze, David, Loizos, Nick, Luffer-Atlas, Debra, Oakley, 3rd, Gerard J, Guo, Qianxu, Iyer, Seema, Rubin, Brian P, Stancato, Louis
Published in Clinical cancer research (15.02.2018)
Published in Clinical cancer research (15.02.2018)
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Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies
Peng, Sheng-Bin, Zhang, Xiaoyi, Paul, Donald, Kays, Lisa M, Ye, Ming, Vaillancourt, Peter, Dowless, Michele, Stancato, Louis F, Stewart, Julie, Uhlik, Mark T, Long, Haiyan, Chu, Shaoyou, Obungu, Victor H
Published in PloS one (08.03.2016)
Published in PloS one (08.03.2016)
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eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
GRAFF, Jeremy R, KONICEK, Bruce W, HURST, Bernadette M, DEDDENS, James A, NEUBAUER, Blake L, STANCATO, Louis F, CARTER, Harry W, DOUGLASS, Larry E, CARTER, Julia H, LYNCH, Rebecca L, DUMSTORF, Chad A, DOWLESS, Michele S, MCNULTY, Ann M, PARSONS, Stephen H, BRAIL, Leslie H, COLLIGAN, Bruce M, KOOP, Jonathan W
Published in Cancer research (Chicago, Ill.) (01.05.2009)
Published in Cancer research (Chicago, Ill.) (01.05.2009)
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Journal Article
A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators
Sutherland, Jeffrey J, Low, Jonathan, Blosser, Wayne, Dowless, Michele, Engler, Thomas A, Stancato, Louis F
Published in Molecular cancer therapeutics (01.02.2011)
Published in Molecular cancer therapeutics (01.02.2011)
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Journal Article
High-content imaging characterization of cell cycle therapeutics through in vitro and in vivo subpopulation analysis
Low, Jonathan, Huang, Shuguang, Blosser, Wayne, Dowless, Michele, Burch, John, Neubauer, Blake, Stancato, Louis
Published in Molecular cancer therapeutics (01.08.2008)
Published in Molecular cancer therapeutics (01.08.2008)
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Journal Article
A Natural Product Ligand of the Oxysterol Receptor, Liver X Receptor
Bramlett, Kelli S, Houck, Keith A, Borchert, Kristen M, Dowless, Michele S, Kulanthaivel, Palaniappan, Zhang, Youyan, Beyer, Thomas P, Schmidt, Robert, Thomas, Jeffrey S, Michael, Laura F, Barr, Robert, Montrose, Chahrzad, Eacho, Patrick I, Cao, Guoqing, Burris, Thomas P
Published in The Journal of pharmacology and experimental therapeutics (01.10.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2003)
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Journal Article
Knockdown of Cancer Testis Antigens Modulates Neural Stem Cell Marker Expression in Glioblastoma Tumor Stem Cells
Low, Jonathan, Dowless, Michele, Shiyanova, Tatiyana, Rowlinson, Scott, Ricci-Vitiani, Lucia, de Maria, Ruggero, Pallini, Roberto, Stancato, Louis
Published in Journal of biomolecular screening (01.08.2010)
Published in Journal of biomolecular screening (01.08.2010)
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Journal Article
A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity
Schmidt, Robert J., Ficorilli, James V., Zhang, Youyan, Bramlett, Kelli S., Beyer, Thomas P., Borchert, Kristen, Dowless, Michele S., Houck, Keith A., Burris, Thomas P., Eacho, Patrick I., Liang, Guosheng, Guo, Li-wei, Wilson, William K., Michael, Laura F., Cao, Guoqing
Published in Journal of lipid research (01.05.2006)
Published in Journal of lipid research (01.05.2006)
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Journal Article
Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin
Dowless, Michele S., Barbee, James L., Borchert, Kristen M., Bocchinfuso, Wayne P., Houck, Keith A.
Published in European journal of pharmacology (04.04.2005)
Published in European journal of pharmacology (04.04.2005)
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Journal Article
Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
Gong, Xueqian, Litchfield, Lacey M., Webster, Yue, Chio, Li-Chun, Wong, Swee Seong, Stewart, Trent R., Dowless, Michele, Dempsey, Jack, Zeng, Yi, Torres, Raquel, Boehnke, Karsten, Mur, Cecilia, Marugán, Carlos, Baquero, Carmen, Yu, Chunping, Bray, Steven M., Wulur, Isabella H., Bi, Chen, Chu, Shaoyou, Qian, Hui-Rong, Iversen, Philip W., Merzoug, Farhana F., Ye, Xiang S., Reinhard, Christoph, De Dios, Alfonso, Du, Jian, Caldwell, Charles W., Lallena, María José, Beckmann, Richard P., Buchanan, Sean G.
Published in Cancer cell (11.12.2017)
Published in Cancer cell (11.12.2017)
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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Gong, Xueqian, Du, Jian, Parsons, Stephen H, Merzoug, Farhana F, Webster, Yue, Iversen, Philip W, Chio, Li-Chun, Van Horn, Robert D, Lin, Xi, Blosser, Wayne, Han, Bomie, Jin, Shaoling, Yao, Sufang, Bian, Huimin, Ficklin, Chris, Fan, Li, Kapoor, Avnish, Antonysamy, Stephen, Mc Nulty, Ann M, Froning, Karen, Manglicmot, Danalyn, Pustilnik, Anna, Weichert, Kenneth, Wasserman, Stephen R, Dowless, Michele, Marugán, Carlos, Baquero, Carmen, Lallena, María José, Eastman, Scott W, Hui, Yu-Hua, Dieter, Matthew Z, Doman, Thompson, Chu, Shaoyou, Qian, Hui-Rong, Ye, Xiang S, Barda, David A, Plowman, Gregory D, Reinhard, Christoph, Campbell, Robert M, Henry, James R, Buchanan, Sean G
Published in Cancer discovery (01.02.2019)
Published in Cancer discovery (01.02.2019)
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Journal Article
Abstract A42: Prexasertib (LY2606368) is highly active as a monotherapy or in combination with chemotherapy in preclinical models of pediatric bone and soft tissue sarcoma
Lowery, Caitlin D., Blosser, Wayne, Dowless, Michele, Renschler, Matthew, Stephens, Jennifer, Beckmann, Richard, Stancato, Louis
Published in Cancer research (Chicago, Ill.) (01.10.2018)
Published in Cancer research (Chicago, Ill.) (01.10.2018)
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LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer
Vakana, Eliza, Pratt, Susan, Blosser, Wayne, Dowless, Michele, Simpson, Nicholas, Yuan, Xiu-Juan, Jaken, Susan, Manro, Jason, Stephens, Jennifer, Zhang, Youyan, Huber, Lysiane, Peng, Sheng-Bin, Stancato, Louis F
Published in Oncotarget (07.02.2017)
Published in Oncotarget (07.02.2017)
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Abstract A32: Selective inhibition of AuroraA by LY3295668 erbumine in neuroblastoma models induces apoptosis through a combination of S-phase DNA damage and mitotic arrest
Dowless, Michele, Kremer, Jill, Lowery, Caitlin, Gong, Xueqian, Klahn, Joseph, Stephens, Jennifer, Hui, Yu-Hua, Blosser, Wayne, Martinez, Ricardo, Du, Jian, Stancato, Louis
Published in Cancer research (Chicago, Ill.) (15.07.2020)
Published in Cancer research (Chicago, Ill.) (15.07.2020)
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Journal Article
Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
Lowery, Caitlin D, Dowless, Michele, Renschler, Matthew, Blosser, Wayne, VanWye, Alle B, Stephens, Jennifer R, Iversen, Philip W, Lin, Aimee Bence, Beckmann, Richard P, Krytska, Kateryna, Cole, Kristina A, Maris, John M, Hawkins, Douglas S, Rubin, Brian P, Kurmasheva, Raushan T, Houghton, Peter J, Gorlick, Richard, Kolb, E Anders, Kang, Min H, Reynolds, C Patrick, Erickson, Stephen W, Teicher, Beverly A, Smith, Malcolm A, Stancato, Louis F
Published in Clinical cancer research (01.04.2019)
Published in Clinical cancer research (01.04.2019)
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Target actionability review to evaluate CDK4/6 as a therapeutic target in paediatric solid and brain tumours
Schubert, Nil A., Chen, Celine Y., Rodríguez, Ana, Koster, Jan, Dowless, Michele, Pfister, Stefan M., Shields, David J., Stancato, Louis F., Vassal, Gilles, Caron, Hubert N., van den Boogaard, Marlinde L., Henssen, Anton G., Molenaar, Jan J.
Published in European journal of cancer (1990) (01.07.2022)
Published in European journal of cancer (1990) (01.07.2022)
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